Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 9 de 9
Filter
1.
Europace ; 23(2): 264-270, 2021 02 05.
Article in English | MEDLINE | ID: mdl-33212484

ABSTRACT

AIMS: Ablation index (AI) is a marker of lesion quality during catheter ablation that incorporates contact force, time, and power in a weighted formula. This index was originally developed for pulmonary vein isolation as well as other left atrial procedures. The aim of our study is to evaluate the feasibility and efficacy of the AI for the ablation of the cavotricuspid isthmus (CTI) in patients presenting with typical atrial flutter (AFL). METHODS AND RESULTS: This prospective multicentre non-randomized study enrolled 412 consecutive patients with typical AFL undergoing AI-guided cavotricuspid isthmus ablation. The procedure was performed targeting an AI of 500 and an inter-lesion distance measurement of ≤6 mm. The primary endpoints were CTI 'first-pass' block and persistent block after a 20-min waiting time. Secondary endpoints included procedural and radiofrequency duration and fluoroscopic time. A total of 412 consecutive patients were enrolled in 31 centres (mean age 64.9 ± 9.8; 72.1% males and 27.7% with structural heart disease). The CTI bidirectional 'first-pass' block was reached in 355 patients (88.3%), whereas CTI block at the end of the waiting time was achieved in 405 patients (98.3%). Mean procedural, radiofrequency, and fluoroscopic time were 56.5 ± 28.1, 7.8 ± 4.8, and 1.9 ± 4.8 min, respectively. There were no major procedural complications. There was no significant inter-operator variability in the ability to achieve any of the primary endpoints. CONCLUSION: AI-guided ablation with an inter-lesion distance ≤6 mm represents an effective, safe, and highly reproducible strategy to achieve bidirectional block in the treatment of typical AFL.


Subject(s)
Atrial Flutter , Catheter Ablation , Aged , Atrial Flutter/diagnosis , Atrial Flutter/surgery , Catheter Ablation/adverse effects , Female , Humans , Male , Middle Aged , Prospective Studies , Reproducibility of Results , Treatment Outcome , Tricuspid Valve/diagnostic imaging , Tricuspid Valve/surgery
2.
J Cardiovasc Med (Hagerstown) ; 14(2): 110-3, 2013 Feb.
Article in English | MEDLINE | ID: mdl-22367567

ABSTRACT

BACKGROUND: Less than 50% of patients implanted with an implantable cardioverter-defibrillator (ICD) receive device therapy during the follow-up. The aim of our study was to prospectively evaluate the predictive role of appropriate ICD therapy on long-term survival of patients implanted for primary or secondary sudden death prevention. METHODS: From 2002 to 2003, 139 consecutive patients [mean age 66±9 years, male 77%, ischemic heart disease 56%, New York Heart Association functional class >II (74%), primary prevention 74%, mean left ventricular ejection fraction 30±9%, cardiac resynchronization ICD 65%] were enrolled. We collected and evaluated device therapies for at least 18 months and recorded survival status for more than 5 years. RESULTS: Over a median follow-up of 18 months, 54 (39%) patients received at least one ICD intervention, with 28 patients receiving only appropriate ICD therapies, 13 only inappropriate therapies and 13 receiving both therapies. At a mean follow-up of 63±12 months, 30 deaths occurred in 130 patients (23%); for nine patients, we had no survival status information. Death was classified as cardiac in 22 (73%) patients, the most common cause was progressive heart failure. In a Cox proportional regression model, an appropriate ICD therapy was associated with a significant increase in the subsequent risk of death (hazard ratio 3.02, P=0.003). CONCLUSION: In patients implanted with ICD or cardiac resynchronization therapy with ICD devices, for primary or secondary sudden cardiac death prevention, appropriate ICD therapy predicts a three-fold greater risk of death.


Subject(s)
Arrhythmias, Cardiac/therapy , Cardiac Resynchronization Therapy/methods , Death, Sudden, Cardiac/prevention & control , Primary Prevention/methods , Risk Assessment/methods , Secondary Prevention/methods , Aged , Arrhythmias, Cardiac/complications , Arrhythmias, Cardiac/mortality , Death, Sudden, Cardiac/epidemiology , Death, Sudden, Cardiac/etiology , Female , Follow-Up Studies , Humans , Incidence , Italy/epidemiology , Male , Proportional Hazards Models , Prospective Studies , Risk Factors , Survival Rate/trends , Time Factors
3.
J Interv Card Electrophysiol ; 35(3): 331-6; discussion 336, 2012 Dec.
Article in English | MEDLINE | ID: mdl-22890483

ABSTRACT

PURPOSE: Patients with permanent atrial fibrillation (AF) who undergo cardiac resynchronization therapy (CRT) may spontaneously recover sinus rhythm during follow-up. We tested the feasibility and efficacy of electrical cardioversion attempted after 3 months of CRT in patients with permanent AF and measured the long-term maintenance of sinus rhythm. METHODS: Twenty-eight consecutive patients with permanent AF in whom CRT defibrillators had been implanted were scheduled for internal electrical cardioversion after 3 months (group A) and were compared with a control group of 27 patients (group B). RESULTS: In group A, 22 patients (79 %) were eligible for cardioversion; sinus rhythm was restored in 18 (82 %) of these, with no procedural complications. After 12 months, 16 patients (58 %) in group A were in sinus rhythm, compared with one group B patient who spontaneously recovered sinus rhythm (4 %, p < 0.001). On 12-month evaluation, ejection fraction had improved in both groups, but a reduction in left ventricular end-systolic volume was recorded only in group A patients (p = 0.018 versus baseline). CONCLUSIONS: In patients with permanent AF, the rhythm control strategy consisting of internal cardioversion, performed by means of the implanted cardioverter-defibrillator after 3 months of CRT, was associated with a high rate of sinus rhythm resumption on long-term follow-up and with a better echocardiographic response to CRT than that seen in patients treated according to a rate control strategy.


Subject(s)
Atrial Fibrillation/physiopathology , Atrial Fibrillation/therapy , Cardiac Resynchronization Therapy/methods , Electric Countershock/methods , Aged , Case-Control Studies , Chi-Square Distribution , Feasibility Studies , Female , Humans , Male , Risk Factors , Statistics, Nonparametric , Treatment Outcome
4.
Ann Noninvasive Electrocardiol ; 15(4): 301-7, 2010 Oct.
Article in English | MEDLINE | ID: mdl-20946551

ABSTRACT

BACKGROUND: Studies on the physiology of the cardiovascular system suggest that generation of the heart rate (HR) signal is governed by nonlinear dynamics. Linear and nonlinear indices of HR variability (HRV) have been shown to predict outcome in heart failure (HF). Aim of the present study is to assess if a HR-related complexity predicts adverse clinical and cardiovascular events at 1 year in patients implanted with cardiac resynchronization therapy (CRT). METHODS: In sixty patients implanted with CRT (Renewal), 24-hour HR data were retrieved at patient discharge and 1-year follow-up. A set of linear indices of HRV were considered: mean HR, standard deviation of normal beat to normal beat (SDANN), and HR footprint. Two novel nonlinear indices were calculated by means of a specific algorithm (OntoSpace): HR-complexity (HR-Co) and HR-entropy (HR-En). Predictors of adverse clinical outcome (functional class deterioration or major hospitalizations for cardiovascular causes or all-cause mortality) and of HRV recovery were sought by means of multivariate analysis. RESULTS: HR-Co and HR-En were found to be highly correlated with the other traditional indices of HRV. Lower baseline values of COMPLEXITY WERE ASSOCIATED WITH ADVERSE CLINICAL OUTCOMES (HAZARD RATIO [HR] 0.71; 95% CONFIDENCE INTERVAL [CI] 0.54-0.95; P < 0.02). CONCLUSION: Complexity and entropy indices, calculated from 24-hour normal beat to normal beat (RR) intervals well represent patient's autonomic function. In this limited set of data, HF patients with lower baseline complexity-related indices, representing a more compromised autonomic function, present worse clinical outcome at 1-year follow-up.


Subject(s)
Cardiac Resynchronization Therapy/methods , Heart Failure/physiopathology , Heart Failure/therapy , Heart Rate , Aged , Female , Follow-Up Studies , Humans , Male , Middle Aged , Predictive Value of Tests , ROC Curve
5.
J Cardiovasc Med (Hagerstown) ; 11(1): 40-4, 2010 Jan.
Article in English | MEDLINE | ID: mdl-19770774

ABSTRACT

OBJECTIVES: Little is known about coronary sinus lead performance in patients with cardiac resynchronization therapy devices. We evaluated the impact of clinical and technical parameters on coronary sinus lead performance over long-term follow-up. METHODS: From February 1999 to July 2004, 235 patients (181 men; mean age, 68 +/- 9 years; mean left ventricular ejection fraction, 26.5 +/- 6.5%; idiopathic dilated cardiomyopathy, 49%; ischemic, 48%; and other cause, 3%) underwent cardiac resynchronization therapy (pacemaker or defibrillator) implantation. RESULTS: On implantation, the only statistically significant difference was observed in mean pacing impedance, which was lower for unipolar leads than for bipolar leads (763 +/- 250 vs. 847 +/- 270 Omega, P = 0.02), and lower in patients with ischemic cardiomyopathy than in those with idiopathic cardiomyopathy (758 +/- 204 vs. 837 +/- 291 Omega, P = 0.03). After a mean follow-up of 41.7 +/- 14.7 months, a significant decrease was observed in mean pacing impedance (from 811 +/- 261 to 717 +/- 284 Omega, P = 0.0026) and mean R-wave amplitude (from 13.2 +/- 6.7 to 10.5 +/- 5.5 mV, P = 0.002), whereas the mean pacing energy threshold increased from 3.6 +/- 10.4 to 9.5 +/- 28 microJ (P = 0.004). On analysis of variance, unipolar lead (P = 0.016) and posterior coronary sinus position (P = 0.049) were related to a greater energy threshold increase. On multivariate analysis (Cox regression), only posterior coronary sinus lead position (P = 0.013) proved to be an independent predictor of long-term significant increase in the stimulation energy threshold. CONCLUSION: Over the long-term follow-up of coronary sinus leads, pacing impedance and R-wave amplitude decreased, whereas the energy threshold increased; unipolar leads and posterior lead location in the coronary sinus were related to a greater energy threshold increase.


Subject(s)
Cardiac Pacing, Artificial , Coronary Sinus/physiopathology , Defibrillators, Implantable , Electric Countershock/instrumentation , Equipment Failure , Heart Diseases/therapy , Pacemaker, Artificial , Aged , Cardiac Pacing, Artificial/adverse effects , Defibrillators, Implantable/adverse effects , Electric Countershock/adverse effects , Electric Impedance , Equipment Design , Equipment Failure Analysis , Female , Heart Diseases/physiopathology , Humans , Male , Middle Aged , Odds Ratio , Pacemaker, Artificial/adverse effects , Proportional Hazards Models , Risk Assessment , Time Factors , Treatment Outcome
6.
Pacing Clin Electrophysiol ; 32 Suppl 1: S141-5, 2009 Mar.
Article in English | MEDLINE | ID: mdl-19250079

ABSTRACT

OBJECTIVE: To compare the rates of all-cause mortality in recipients of cardiac resynchronization therapy devices without (CRT-PM) versus with defibrillator (CRT-D). METHODS: Between February 1999 and July 2004, 233 patients (mean age = 69 +/- 8 years, 180 men) underwent implantation of CRT-PM or CRT-D devices. New York Heart Association (NYHA) heart failure functional class II was present in 11%, class III in 69%, and class IV in 20% of patients; mean left ventricle ejection fraction (LVEF) was 26.5 +/- 6.5 %, 48% presented with idiopathic dilated cardiomyopathy and 49% with ischemic heart disease. Cox multiple variable regression analysis was performed in search of predictors of death. RESULTS: The clinical characteristics of the 117 CRT-PM and 116 CRT-D recipients were similar, except for LVEF (28.2 +/- 6.2% vs 25.0 +/- 6.5%, respectively; P < 0.001), and ischemic versus nonischemic etiology of heart failure (41% vs 56%, respectively P = 0.02). Over a mean follow-up of 58 +/- 15 months, no significance difference in overall mortality rate was observed between the two study groups. Male sex, NYHA functional class IV, and atrial fibrillation at implant were significant predictors of death. CONCLUSIONS: There was no difference in long-term survival rate among patients with CRT-D versus CRT-PM, although CRT-D more effectively lowered the sudden death rate. Male sex, NYHA functional class IV, and atrial fibrillation predicted the worst prognosis.


Subject(s)
Cardiac Pacing, Artificial/mortality , Death, Sudden, Cardiac/epidemiology , Death, Sudden, Cardiac/prevention & control , Heart Failure/epidemiology , Heart Failure/prevention & control , Pacemaker, Artificial/statistics & numerical data , Risk Assessment/methods , Survival Analysis , Aged , Female , Humans , Italy/epidemiology , Longitudinal Studies , Male , Prevalence , Risk Factors , Treatment Outcome
7.
Pacing Clin Electrophysiol ; 30 Suppl 1: S47-9, 2007 Jan.
Article in English | MEDLINE | ID: mdl-17302716

ABSTRACT

BACKGROUND: Little is known regarding the long-term performance of coronary sinus (CS) leads, which have an effect on the longevity of cardiac resynchronization therapy (CRT) systems. METHODS: This study included 109 patients (79 men) whose mean age was 68 +/- 9 years, New York Heart Association (NYHA) functional class 3.2 +/- 0.5, and left ventricular ejection fraction 25.6 +/- 6.6%, and who underwent CRT (n = 45) or CRT-D (n = 64) systems implants for management of idiopathic (53%), ischemic (40%), or miscellaneous (7%) dilated cardiomyopathy. Unipolar (n = 57) or bipolar (n = 52) leads were placed into the CS venous system. RESULTS: At implant, no significant difference was observed between unipolar and bipolar leads with respect to mean sensing performance (14 +/- 6 mV vs 14 +/- 8 mV, P = 0.97), pacing impedance (875 +/- 234 ohms vs 943 +/- 331 ohms, P = 0.24), and stimulation energy threshold (2 +/- 3.2 muJ vs 1.13 +/- 1.5 muJ, P = 0.08). At a median follow-up of 33 months, a significant decrease in stimulation impedance and increase in stimulation energy threshold was observed with unipolar (689 +/- 122 vs 875 +/- 234 ohms, P < 0.01, and 8.34 +/- 10.4 muJ vs 2 +/- 3.2 muJ, P < 0.001, respectively) as well as with bipolar (735 +/- 268 ohms vs 943 +/- 331 ohms, P < 0.01, and 4.81 +/- 9.92 vs 1.13 +/- 1.5 muJ, P = 0.02, respectively) leads. No significant difference in sensing performance was observed with either type of lead (10 +/- 5 mV vs 14 +/- 6 mV and 10 +/- 6 mV vs 14 +/- 8 mV, respectively). At long-term follow-up, no significant difference among any sensing or stimulation parameter was observed between unipolar and bipolar leads. CONCLUSIONS: At long-term follow-up, a significant increase in the energy required for stimulation was observed, whereas sensing performance remained unchanged. The increase in energy capture threshold was less marked with bipolar than with unipolar leads.


Subject(s)
Cardiac Pacing, Artificial/methods , Heart Failure/therapy , Pacemaker, Artificial/standards , Aged , Coronary Sinus , Female , Follow-Up Studies , Humans , Male , Middle Aged , Treatment Outcome
8.
Pacing Clin Electrophysiol ; 26(10): 2036-8, 2003 Oct.
Article in English | MEDLINE | ID: mdl-14516347

ABSTRACT

Spurious discharges due to late insulation break in an IS-1 pacing/sensing connector prompted ICD lead removal in 65-year-old man. The tip of the lead was easily freed and pulled back into the SVC by the superior approach. After that, the lead became trapped. The distal part of the lead was caught and easily withdrawn by inferior approach. Superior venous angiography showed extravascular location of the entrapped part of the lead due to the unintentional percutaneous puncture of the innominate vein after piercing the subclavian vein. It may be desirable to use contrast venography before intervention of extraction to ensure venous patency and lead location.


Subject(s)
Defibrillators, Implantable , Subclavian Vein/injuries , Aged , Device Removal , Equipment Failure , Extravasation of Diagnostic and Therapeutic Materials , Humans , Male , Phlebography , Reoperation , Ventricular Fibrillation/therapy
9.
Ital Heart J Suppl ; 4(6): 510-3, 2003 Jun.
Article in Italian | MEDLINE | ID: mdl-19400057

ABSTRACT

The long QT syndrome is characterized by the observed association of "torsade de pointes" and the prolongation of the QT interval on the electrocardiogram. Acquired long QT syndrome typically affects older individuals, being often associated with the action of some drugs. Hypokalemia is a frequent cause of QT lengthening on the electrocardiogram. Chronic assumption of licorice may be an unusual cause of hypokalemia, due to its mineralocorticoid-like action. In this paper we describe a case of cardiac arrest due to "torsade de pointes" resulting from a marked hypokalemia caused by the patient's habit of eating daily a not negligible quantity of licorice.


Subject(s)
Glycyrrhiza/toxicity , Heart Arrest/etiology , Hypokalemia/complications , Aged , Electrocardiography , Heart Arrest/chemically induced , Heart Arrest/drug therapy , Heart Conduction System/drug effects , Humans , Hypokalemia/etiology , Long QT Syndrome/chemically induced , Long QT Syndrome/complications , Male , Potassium Chloride/therapeutic use , Torsades de Pointes/chemically induced , Torsades de Pointes/complications , Treatment Outcome
SELECTION OF CITATIONS
SEARCH DETAIL
...