ABSTRACT
BACKGROUND: Global travel increasis practitioner's confrontation with very special infectious diseases, like hemorrhagic viral diseases that are traditionally rare in European countries. Prompt diagnosis and subsequent induction of therapy are essential to prevent high rates of severe and lethal complications. ANAMNESIS: A 59-year-old man complained deterioration of general health after a 3-week vacation to South Africa. He presented fever and hemorrhagic erythema with pustula surrounded by necrotic margin on the right calf. COURSE AND THERAPY: On the second day of inpatient treatment, a papulovesiculous, partly hemorrhagic exanthema appeared. With a tentative diagnosis of Rickettsiosis, we performed specific diagnostics by serology and biopsy. Therapy was initiated with doxycycline (200 mg/d) for 7 days. Under this regimen clinical symptoms healed without consequences. Rickettsioses are ubiquitious zoonoses that are caused by various Rickettsia subtypes. The stay in endemic regions together with signs of fever, reduced general health, eschar and exanthema are suspicious for this disease. Therapy should be initiated immediately in cases of clinical suspicion with a characteristic case history. The seroconversion, which appears later in course, should not give reason for avoiding early skin biopsy due to the potentially fatal course of the disease. Biopsy enables early histological proof of a dermal vasculitic inflammation pattern and PCR analysis before subsequent serological controls and proofs.
Subject(s)
Early Diagnosis , Rickettsia Infections/diagnosis , Rickettsia Infections/pathology , Skin/pathology , Biopsy , Diagnosis, Differential , Doxycycline/therapeutic use , Humans , Male , Middle Aged , Rickettsia Infections/drug therapy , TravelSubject(s)
Bites, Human/therapy , Health Knowledge, Attitudes, Practice , Lacerations/diagnosis , Lacerations/therapy , Skin Diseases, Bacterial/diagnosis , Skin Diseases, Bacterial/therapy , Adult , Anti-Bacterial Agents/therapeutic use , Bites, Human/diagnosis , Combined Modality Therapy , Debridement/methods , Diagnosis, Differential , Humans , Male , Skin/drug effects , Skin/injuries , Treatment OutcomeSubject(s)
Giant Cell Arteritis/complications , Scalp Dermatoses/surgery , Scalp/pathology , Skin Transplantation/methods , Skin, Artificial , Wound Closure Techniques , Aged, 80 and over , Combined Modality Therapy/methods , Female , Giant Cell Arteritis/pathology , Giant Cell Arteritis/therapy , Humans , Necrosis/pathology , Necrosis/surgery , Scalp/surgery , Scalp Dermatoses/pathology , Treatment OutcomeABSTRACT
Stevens-Johnson syndrome and toxic epidermal necrolysis are some of the most serious, usually drug-induced, skin reactions. We report a case of severe toxic epidermal necrolysis in a child, which in addition to ophthalmic sequelae, caused extensive hypertrophic scarring of the skin. Such a course is uncommon and has rarely been described in the literature.
Subject(s)
Cicatrix/etiology , Skin/pathology , Stevens-Johnson Syndrome/complications , Antibodies, Monoclonal/therapeutic use , Child , Dermatologic Agents/therapeutic use , Female , Glucocorticoids/therapeutic use , Humans , Infliximab , Prednisolone/therapeutic use , Stevens-Johnson Syndrome/drug therapySubject(s)
Dermatologic Agents/therapeutic use , Hand Dermatoses/diagnosis , Hand Dermatoses/drug therapy , Laminin/immunology , Pemphigoid, Bullous/diagnosis , Pemphigoid, Bullous/drug therapy , Aged , Female , Hand Dermatoses/immunology , Humans , Male , Middle Aged , Pemphigoid, Bullous/immunology , Treatment OutcomeABSTRACT
Red ear syndrome (RES) is characterized by the attack-like occurrence of erythema, edema and dysesthesia of one or less frequently both ears. We report the case of a 31-year-old woman with stabbing pain and marked erythema and discrete edema of one ear, existing for 4 months, occasionally accompanied by burning and local hyperhidrosis. Differential diagnoses such as perichondritis, contact dermatitis, erysipelas and other infections were ruled out. Based on her history, the clinical pattern and the unremarkable further diagnostics, we diagnosed RES. A review of the literature is included.
Subject(s)
Ear Diseases/diagnosis , Edema/diagnosis , Erythema/diagnosis , Adult , Analgesics, Non-Narcotic/therapeutic use , Ear Diseases/drug therapy , Edema/drug therapy , Erythema/drug therapy , Female , Humans , Hyperhidrosis/diagnosis , Ibuprofen/therapeutic use , Migraine Disorders/diagnosis , Pain/diagnosis , Paresthesia/diagnosis , Steroids/therapeutic use , Syndrome , Tinnitus/diagnosisABSTRACT
BACKGROUND: The term 'pilonidal sinus' (PS) reflects an acute exacerbating, purulent, fistulating chronic inflammation located in the coccyx region. Systematic histological investigations are scarce, and the etiology has remained controversial. METHODS: Histological and immunohistochemical characterization of totally excised material of 27 patients (68 specimens) with PS (no antecedent and no current clinical signs of hidradenitis suppurativa, HS) and its correlation with data on HS which we published earlier. RESULTS: Follicular hyperplasia/hyperkeratosis and interfollicular epidermal hyperplasia are main features of PS. Early pathology seems to take place at terminal hair follicles, whereas sinus tract formations are a secondary event. Focused regions show an inflammatory mixed infiltrate consisting of CD3+, CD4+, CD8+, CD68+ and CD79+ cells. CONCLUSIONS: PS and HS have various common characteristics at the histological and immunohistochemical level. Considering PS as a unilocalized type of HS, risk factors known in the latter should henceforth be evaluated in PS as well.
Subject(s)
Hidradenitis Suppurativa/pathology , Pilonidal Sinus/pathology , Adolescent , Adult , Antigens, CD/immunology , Female , Hair Follicle/immunology , Hair Follicle/pathology , Hidradenitis Suppurativa/immunology , Humans , Immunohistochemistry , Inflammation/immunology , Inflammation/pathology , Male , Pilonidal Sinus/immunology , Young AdultSubject(s)
Antibodies, Monoclonal/therapeutic use , Dermatologic Agents/therapeutic use , Stevens-Johnson Syndrome/drug therapy , Adult , Cyclooxygenase 2 Inhibitors/adverse effects , Etoricoxib , Humans , Infliximab , Male , Pyridines/adverse effects , Stevens-Johnson Syndrome/etiology , Sulfones/adverse effects , Treatment OutcomeABSTRACT
Hidradenitis suppurativa (acne inversa) is a chronic suppurative and scarring inflammatory disease with predilection in the apocrine gland-bearing areas. Histological investigations in the 1990s showed keratotic occlusion of the terminal follicle structure to be the initial cause. Our investigations describe and reproduce the morphology and try to figure out very early lesions of HS. A total of 262 operative specimens from 60 patients were investigated by routine histology and 11 operative specimens by immunohistochemistry: HS is dominated by a heterogeneous histological image. 82% of the surgical specimens showed mild or pronounced follicular hyperkeratosis, whereas an isotopic hyperplasia of follicular epithelium was evident in 77%. Pronounced perifolliculitis was seen in 68% and rupture of the follicle structure in 28%. Features which had not so far been described in detail were: epidermal psoriasiform hyperplasia (43%) and subepidermal interfollicular inflammatory infiltrate (78%). In all 11 specimens, immunohistochemical investigations showed a perifollicular and subepidermal inflammation of CD-3-, CD-4-, CD-68-, CD-79- and CD-8-cells, the latter with a striking selective epitheliotropism. To conclude, we could show follicular hyperkeratosis and lymphocytic perifollicular inflammation as early patterns in pathogenesis, whereas rupture of the follicle structure takes place later. Finally, it seems that there are two hot spots of inflammatory events (perifollicular and subepidermal) composed of a comparable inflammatory cell mixture. The CD-8 cell epitheliotropism (follicular and epidermal) described here and its influence in follicular hyperkeratosis, in hyperplasia of follicular epithelium and in epidermal psoriasiform hyperplasia will be of further interest, for instance, concerning early pharmacological intervention.
Subject(s)
Epidermis/pathology , Hair Follicle/pathology , Hidradenitis Suppurativa/pathology , Adolescent , Adult , Aged , Antigens, CD/metabolism , CD4-Positive T-Lymphocytes/pathology , CD8-Positive T-Lymphocytes/pathology , Epithelium/pathology , Female , Folliculitis/pathology , Humans , Hyperplasia/pathology , Inflammation/pathology , Keratosis/pathology , Lymphocytes/metabolism , Lymphocytes/pathology , Middle Aged , Young AdultABSTRACT
Inflammatory changes of the oral mucosa in children can have a variety of infectious and non-infectious etiologies. We report on a 10-year-old boy with progressive cobblestone-like changes and erosions of oral mucosa over six months, which turned out to be early oral manifestations of Crohn disease.