ABSTRACT
INTRODUCTION: Burns are known to have an effect on coagulation in the early period after burn. Current coagulation tests have been criticised in acute burns due to their inherent limitations. This study aims to investigate the potential for a new quantitative functional biomarker of clot quality, fractal dimension, to identify changes in clot microstructure as a result of the burn inflammatory response and its treatment. METHODS: A total of fifty-eight burn patients were included in this prospective case-controlled study. The control group (29 patients mean TBSA 1%), and case group (29 patients mean TBSA 30%) were compared at baseline and the case group investigated further over four time points (baseline, 12h, 24h and 5-7 days). Fractal analysis was performed, as well as current markers of coagulation, inflammatory markers and point-of-care tests, Thromboelastography and Multiplate analysis. RESULTS: Fractal dimension did not differ between groups at admission (1.73±0.06 and 1.72±0.1), and fell within the healthy index normal range (1.74±0.7), suggesting a normal clot microstructure in the early period after burn. Fractal dimension significantly reduced from baseline over the first 24h following injury (1.59±0.03 p<0.005), indicating a significant reduction in mechanical clot strength and functionality consistent with a hypocoagulable state, not identified with other markers. CONCLUSIONS: This is the first study to quantify the changes in clot microstructure following burn injury. This study confirms clot microstructure is significantly altered during the first 24h after burn, with the production of a weaker, more porous fibrin clot, consistent with a hypocoagulable state.
Subject(s)
Blood Coagulation Disorders/blood , Burns/blood , Inflammation/blood , Adolescent , Adult , Aged , Aged, 80 and over , Blood Coagulation Disorders/metabolism , Blood Coagulation Disorders/pathology , Blood Coagulation Tests , Burns/pathology , Burns/therapy , Case-Control Studies , Colloids/therapeutic use , Disease Progression , Factor VIII/metabolism , Female , Fibrin Fibrinogen Degradation Products/metabolism , Fluid Therapy/methods , Fractals , Humans , Inflammation/metabolism , Interleukin-6/metabolism , Male , Microscopy, Electron, Scanning , Middle Aged , Platelet Aggregation , Platelet Function Tests , Procalcitonin/metabolism , Prospective Studies , Thrombelastography , Tumor Necrosis Factor-alpha/metabolism , Young AdultABSTRACT
INTRODUCTION: Low socio-economic status is thought to be associated with increased burn risk, however the significance and generalisability across different populations and cultures has been questioned. METHODS: A nine-year retrospective study of burn presentations to a large teaching hospital (2005-2014) was performed to investigate the association between socio-economic status and burns. Demographic and injury data was collected via the trust 'Information portal'. The Welsh Index of Multiple: Deprivation 2011 was used to score for socio-economic status. Chi-squared test and Odds Ratios were calculated and statistical significance defined as p<0.05 throughout. RESULTS: 6441 burns were identified, with 755 (11.7%) admitted. Overall incidence rates were the highest published in the UK (0.35/1000/year) with sub group analysis showing the highest rates in under fives and males. Significant relationships between both age and burn mechanism and gender and burn mechanism (p=0.0005) were identified. Scald (67.1%) was the most common mechanism with the upper limb (48%) most commonly burned. Chi square analysis demonstrated a significant relationship between socio-economic deprivation, age and burn incidence (p≤0.0005), with a disproportionately high number of burns in patients under the age of 16 in the most deprived quintile (OR 1.23; 95% CI 1.06-1.44). CONCLUSION: This study specifically highlights patients under the age of 16 living in poorer socio-economic areas as the most at risk of suffering burns receiving hospital attention. This study demonstrates burns as a significant public health issue, and the results should aid in designing specific burn prevention strategies to target high-risk groups.
Subject(s)
Burns/epidemiology , Social Class , Adolescent , Adult , Age Factors , Aged , Aged, 80 and over , Burns/prevention & control , Child , Child, Preschool , Cohort Studies , Emergency Service, Hospital , Female , Hospitals, University , Humans , Incidence , Infant , Male , Middle Aged , Retrospective Studies , Risk Factors , Sex Factors , United Kingdom/epidemiology , Wales/epidemiology , Young AdultABSTRACT
Endometriosis is the presence or growth of endometrial tissue outside the uterus, most commonly affecting the ovaries, uterine ligaments and the peritoneum. Cutaneous endometriosis is much rarer, and is mostly found at the sites of surgical scars, such as laparoscopies, hysterectomies and caesarean sections. We present a rare case of scar endometriosis in a 33 year-old women presenting to the plastic surgeon as a possible skin malignancy and review the literature.
Subject(s)
Cesarean Section , Cicatrix/pathology , Endometriosis/pathology , Skin Diseases/pathology , Adult , Dermis/pathology , Endometriosis/surgery , Fasciotomy , Female , Humans , Skin Diseases/surgeryABSTRACT
Despite being one of the rarest congenital upper limb abnormalities, a wide spectrum of the typical mirror hand has been described in the literature. We report a very interesting case of a new variant of mirror hand presenting in a 78-year-old man. The unique features of the case include the age at diagnosis, the anatomical features present and the acquired function despite no form of reconstructive surgery.