ABSTRACT
Background Oral malignant melanoma is the most common, but aggressive oral cancer in dogs with poor prognosis. Electrochemotherapy (ECT) has therapeutic potential in such tumors as effective local treatment. Therefore, the aim of this prospective clinical study was to evaluate treatment effectiveness of ECT in as first line treatment for canine oral malignant melanoma, and search for factors influencing treatment outcome. Methods Sixty-seven canines with primary oral malignant melanoma, non-candidates for first-line therapy, were enrolled. All dogs received ECT and follow-up exams for the span of two years. Results Based on RECIST criteria, the objective response rate was 100%, 89.5%, 57.7%, and 36.4%, in stage I, II, III and IV, respectively. Only patients in stage I, II and III with partial or complete response improved their quality of life. The median time to progression was 11, 7, 4 and 4 months, and median survival time after the treatment was 16.5, 9.0, 7.5 and 4.5 months, for patients in stage I, II, III and IV, respectively. Significantly better was local response in stage I and II disease (p = 0.0013), without the bone involvement (p = 0.043) Conclusions Electrochemotherapy is effective local treatment of oral canine malignant melanoma when no alternative treatment is available. Better response is expected in stage I and II patients with tumors without bone involvement.
Subject(s)
Dog Diseases/drug therapy , Electrochemotherapy/veterinary , Melanoma/veterinary , Mouth Neoplasms/veterinary , Animals , Disease Progression , Disease-Free Survival , Dog Diseases/mortality , Dog Diseases/pathology , Dogs , Electrochemotherapy/instrumentation , Electrochemotherapy/methods , Female , Follow-Up Studies , Male , Melanoma/drug therapy , Melanoma/mortality , Melanoma/pathology , Mouth Neoplasms/drug therapy , Mouth Neoplasms/mortality , Mouth Neoplasms/pathology , Neoplasm Staging/veterinary , Prospective Studies , Response Evaluation Criteria in Solid Tumors , Treatment OutcomeABSTRACT
El cáncer es la segunda causa de muerte por enfermedad en el mundo y su incidencia sigue creciendo con el aumento de la contaminación y del envejecimiento del promedio poblacional. La Argentina no es la excepción, como lo muestran las estadísticas del Ministerio de Salud (Estadísticas Vitales de 2002 a 2006). Además de un problema médico, el cáncer es un problema económico: el impacto en la economía es enorme y la tendencia actual en los países centrales es invertir recursos en investigación, prevención y tratamiento precoz de la enfermedad, ya que el tratamiento de estadios avanzados resulta, a nivel poblacional, una carga económica excesiva y potencialmente inabordable aun por los países con mayores recursos.
