ABSTRACT
Studies of B virus (Herpesvirus simiae) antibody in several species of macaque lead to the following generalizations. Newborn monkeys are not infected with B virus, even when born of seropositive mothers. Young monkeys remain uninfected until they become adults. The majority of adults develop B virus antibody unless their physical contact with seropositive adults is restricted. These observations are consistent with sexual transmission of B virus and classification of the disease in monkeys as venereal. However, infection at oral and dermal sites also occurs and may play a part in monkey-to-monkey transmission. Epizootics of B virus occurred during early attempts to start B virus-free breeding colonies. They appeared to originate from reactivated latent B virus in adult monkeys which had only low titres of antibody. The stress produced when groups of adult strangers were assembled to form breeding colonies was the most effective known inducer of latent B virus. Total exclusion of animals with any trace of antibody has enabled the establishment of new breeding colonies which are free from B virus.
Subject(s)
Herpesviridae Infections/veterinary , Macaca , Monkey Diseases/transmission , Age Factors , Animals , Animals, Laboratory , Antibodies, Viral/analysis , Female , Genitalia/microbiology , Herpesviridae Infections/microbiology , Herpesviridae Infections/transmission , Herpesvirus 1, Cercopithecine/immunology , Herpesvirus 1, Cercopithecine/isolation & purification , Macaca fascicularis , Macaca mulatta , Male , Monkey Diseases/microbiology , Mouth/microbiology , Skin/microbiologySubject(s)
Oviducts , Ovum/transplantation , Animals , Female , Haplorhini , Macaca mulatta , Methods , Oviducts/surgery , Pregnancy , Transplantation, Autologous , UterusABSTRACT
The yields of translocations in spermatocytes after irradiation of spermatogonia of Rhesus monkeys with doses of 100, 200 or 300 rad X-rays were low, and consistent with a humped dose-response curve with a peak at about 200 rad. Such a curve would agree well with earlier results on the marmoset and man, but the yields at any dose in the Rhesus monkey were lower.
