ABSTRACT
El flurbiprofeno es un analgésico antiinflamatorio no esteroideo del grupo de los aril-propiónicos. Posee una actividad antiagregante plaquetaria importante que ejerce de forma reversible y cuyo efecto desaparece en 24 h. Esta cualidad es uno de los motivos de su resurgimiento actual en el arsenal terapéutico. En anestesia se está indicando para la sustitución de la profilaxis secundaria de clopidogrel o ticlopidina, con un nivel de evidencia II. Sólo son necesarias dosis de 50 a 100 mg/día para ejercer este efecto de forma similar al AAS, ya que es muy potente y raramente a esta dosis prolonga el tiempo de hemorragia. Se revisan distintos aspectos farmacocinéticos, su perfil clínico de seguridad, estudios sobre su eficacia antiagregante y sus potenciales efectos adversos
Flurbiprofen is a non steroidal anti-inflammatory drug of the aryl-propionic acid class. It possesses an important platelet antiaggregant activity, that is reversible, and its effects disappear in 24 h. This characteristic is one of the causes for its renewed importance in the therapeutic arsenal. Now, in neuraxial anesthesia, flurbiprofen is indicated for the substitution of secondary prophylaxis when the patients are treated with clopidogrel or ticlopidine, with a II level of evidence. Only 50-100 mg/day are necessary to get the same effect as aspirin, because flurbiprofen is very powerful and rarely prolongs the hemorrhagic time. We review several pharmacokinetic aspects, clinical safety profile, antiaggregant efficacy studies and its potencial adverse effects
Subject(s)
Humans , Flurbiprofen/therapeutic use , Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Platelet Aggregation Inhibitors/therapeutic use , Anti-Inflammatory Agents, Non-Steroidal/adverse effects , Anti-Inflammatory Agents, Non-Steroidal/pharmacokinetics , Platelet Aggregation Inhibitors/adverse effects , Platelet Aggregation Inhibitors/pharmacokinetics , Flurbiprofen/pharmacokinetics , Flurbiprofen/adverse effectsSubject(s)
Aortic Aneurysm/surgery , Aortic Dissection/surgery , Cesarean Section , Pregnancy Complications, Cardiovascular/surgery , Adult , Anesthesia, General , Anesthesia, Obstetrical , Aorta , Atropine/pharmacology , Blood Vessel Prosthesis Implantation , Emergencies , Extracorporeal Circulation , Female , Fentanyl/pharmacology , Fetus/drug effects , Hemodynamics/drug effects , Humans , Infant, Newborn , Laparotomy , Piperidines/pharmacology , Pregnancy , Remifentanil , Succinylcholine/pharmacologyABSTRACT
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