ABSTRACT
Vitiligo is the most common depigmenting disorder, with a worldwide occurrence of 0.1-2% in the general population. Multiple conditions have been described colocalized in vitiligo patches, like psoriasis or lichen planus. However, actinic granuloma has not been described in association with vitiligo lesions so far.
ABSTRACT
Melanoma involving the conjunctiva is extremely rare. Graver prognosis has been reported with primary conjunctival melanoma than with their cutaneous counterparts [Collin et al.: Aust N Z J Ophthalmol 1986;14:29-34]. Among conjunctival melanomas, two significant risk factors for tumour-related death have been identified: (i) age older than 55 years and (ii) unfavourable tumour location (caruncle, cornea, fornix, palpebral conjunctiva) [Werschnik and Lommatzsch: Am J Clin Oncol 2002;25:248-255]. Here we present a rare case of lentigo maligna involving the palpebral, bulbar conjunctiva and the caruncle. We describe dermoscopic patterns observed and the use of a novel ocular melanoma therapy with topical imiquimod.
ABSTRACT
Proteasome inhibitors are emerging as a promising class of anti-cancer therapeutic agents. Bortezomib (PS341) is the first proteosome inhibitor with clinical significance. It acts by blocking vital functions of tumoral cells in myeloma, inducing apoptosis. Its toxicity is usually manageable. Gastrointestinal symptoms, peripheral neuropathy, neuropathic pain and thrombocytopenia are described as the most common side effects. We report on a case of cutaneous lesions induced by bortezomib in a patient with relapsed multiple myeloma (MM).
Subject(s)
Antineoplastic Agents/adverse effects , Boronic Acids/adverse effects , Drug Eruptions/etiology , Multiple Myeloma/drug therapy , Protease Inhibitors/adverse effects , Pyrazines/adverse effects , Aged , Anti-Inflammatory Agents/therapeutic use , Antineoplastic Agents/therapeutic use , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Boronic Acids/therapeutic use , Bortezomib , Combined Modality Therapy , Cyclophosphamide/administration & dosage , Dexamethasone/administration & dosage , Doxorubicin/administration & dosage , Drug Eruptions/drug therapy , Hematopoietic Stem Cell Transplantation , Humans , Male , Melphalan/administration & dosage , Multiple Myeloma/complications , Multiple Myeloma/surgery , Prednisone/therapeutic use , Protease Inhibitors/therapeutic use , Pyrazines/therapeutic use , Salvage Therapy , Vincristine/administration & dosageSubject(s)
Tattooing/adverse effects , Warts/diagnosis , Adolescent , Diagnosis, Differential , Female , Humans , Leg/pathology , Warts/etiology , Warts/pathologyABSTRACT
Cutaneous diseases are often found in obese patients but, to our knowledge, mucinous disorders have not been previously reported in association with obesity. Two cases of localized lichen myxoedematosus (papular mucinosis) in two women with morbid obesity are described. Both patients underwent a low-calorie diet for a 1-year period in one case, and for 4 months in the other one, as the only treatment. There was complete resolution of cutaneous lesions at the same time that an important weight loss was observed. Nevertheless, although spontaneous regression is not frequent, it could not be disregarded in either of these two cases.
Subject(s)
Mucinoses/etiology , Obesity, Morbid/complications , Skin Diseases, Papulosquamous/etiology , Adult , Female , Humans , Middle Aged , Mucinoses/pathology , Skin Diseases, Papulosquamous/pathologyABSTRACT
La queratosis seborreica es uno de los tumores epidérmicos benignos más frecuentes encontrados en la práctica clínica. Su transformación maligna es excepcional. Presentamos el caso de la aparición inusual de dos queratosis seborreicas irritadas simétricas en los brazos de un trasplantado renal (AU)
Subject(s)
Adult , Male , Humans , Keratosis, Seborrheic/diagnosis , Keratosis, Seborrheic/etiology , Kidney Transplantation/adverse effects , Keratosis, Seborrheic/surgerySubject(s)
Contraceptives, Oral/adverse effects , Sweet Syndrome/chemically induced , Adult , Drug Therapy, Combination , Female , Follow-Up Studies , Humans , Menstruation Disturbances/drug therapy , Mometasone Furoate , Prednisone/administration & dosage , Pregnadienediols/administration & dosage , Sweet Syndrome/drug therapy , Treatment OutcomeABSTRACT
Se comunica un caso de estomatitis nicotínica en un varón de 65 años, fumador de pipa, que acude a consulta por presentar en el paladar múltiples lesiones blanquecinas indoloras. El estudio histológico muestra lesiones papulares relacionadas con la desembocadura de las glándulas salivales menores. Hoy se acepta que la estomatitis nicotínica típica cursa con lesiones blanquecinas orales de diferente conducta biológica que las leucoplasias con disqueratosis y que en modo alguno deben ser consideradas precancerosas (AU)
Subject(s)
Aged , Male , Humans , Stomatitis/diagnosis , Palate, Soft/pathology , Tobacco Use Disorder/adverse effects , Stomatitis/etiology , Stomatitis/therapy , Precancerous Conditions/diagnosis , Tobacco Use CessationABSTRACT
Las linfangiectasias cutáneas se han descrito clásicamente como una rara complicación tras mastectomía radical o tratamiento radioterápico o quirúrgico de carcinomas de cervix con o sin linfadenectomía. El principal factor desencadenante que se ha barajado es la obstrucción linfática profunda. Con posterioridad han aparecido en la literatura algunos casos cuyos antecedentes parecen tener más relación con factores locales en la matriz intercelular dérmica, que con daño profundo del sistema linfático.Describimos el caso de un linfangioma adquirido localizado en vulva tras una histerectomía radical con radioterapia posterior debido a un carcinoma de cervix y discutiremos la etiopatogenia de esta entidad (AU)
Subject(s)
Female , Middle Aged , Humans , Lymphangiectasis/etiology , Hysterectomy/adverse effects , Lymphangiectasis/diagnosis , Lymphangiectasis/pathology , Lymphangiectasis/radiotherapy , Vulva/pathology , Postoperative Complications , Carcinoma, Squamous Cell/surgery , Lymph Node Excision/methods , Radiotherapy/methodsABSTRACT
Pancreatic involvement has been studied in 70 HIV infected patients, in diverse stages, that were treated with didanosine (ddI), both as monotherapy or associated to zidovudine; 38% of patients presented adverse reaction that obliged to withdraw the medication: pancreatitis (4%), hyperamylasemia (21%) and abdominal pain and/or diarrhea (12%). The possible causes in presentation of adverse effects were evaluated: route of infection, stage of HIV infection, use of pentamidine or trimethoprim-sulfamethoxazole for preventing Pneumocystis carinii pneumonia, administration of ddI in monotherapy or in combined form with zidovudine, time of treatment and level of CD4 lymphocytes. The outcome of adverse effects is related significantly only with the most advanced stage of HIV infection.
Subject(s)
Antiviral Agents/adverse effects , Didanosine/adverse effects , HIV Infections/drug therapy , Pancreatic Diseases/chemically induced , Acute Disease , Antiviral Agents/administration & dosage , CD4 Lymphocyte Count , Didanosine/administration & dosage , Drug Therapy, Combination , Female , HIV Infections/immunology , Humans , Male , Pancreatitis/chemically induced , Zidovudine/administration & dosageABSTRACT
The most serious complication of curative therapy for Hodgkin's disease is the development of a second malignancy. A patient who developed a low grade non-Hodgkin's lymphoma three years and a half after combined-modality therapy for Hodgkin's disease, is described. It is exceptional this type of non-Hodgkin's lymphoma as a second neoplasm after cytotoxic treatment for Hodgkin's disease. Pathogenic relationships between both processes are discussed.
