ABSTRACT
The study of the bioactive compounds present in Annona muricata extracts has won popularity due to the growing evidence of its medicinal properties, including anticancer and antidiabetic effects. The aim of this study was to systematically analyze the scientific evidence regarding A. muricata's hypoglycemic effect and the factors affecting the composition of bioactive compounds in different extracts. In vivo, in vitro, and in silico studies were analyzed in the PubMed database following the strategies proposed by the PRISMA guidelines. It was identified that the methodology and results of the articles were heterogeneous. The hypoglycemic function was found to be mediated by multiple effects at the molecular level, including enzymatic inhibition, pancreatic ß cells proliferation stimulation, and food intake-related genes regulation. These effects depend on several factors such as plant bioactive compounds content, extraction method, and characteristics of the organism that consumes it. Therefore, this review exhibits the necessity of further research, using established doses according to the bioactive compounds content in A. muricata.
Subject(s)
Annona , Hyperglycemia , Hyperglycemia/drug therapy , Hypoglycemic Agents/pharmacology , Hypoglycemic Agents/therapeutic use , Plant Extracts/pharmacology , Plant Extracts/therapeutic useABSTRACT
Resumen El objetivo principal de este estudio fue identificar variables sociodemográficas y psicosociales capaces de predecir las conductas alimentarias de riesgo (CAR) en estudiantes de bachillerato. Participaron 988 adolescentes (541 mujeres y 447 hombres) de entre 14 y 18 años de edad (M = 16.79, DE = 1.50). Además de las CAR (Atracón-purga, Medidas compensatorias y Restricción), examinadas a través del Cuestionario Breve de Conductas Alimentarias de Riesgo, fueron evaluadas las variables psicosociales siguientes: apoyo familiar y de amigos, ajuste escolar, victimización, ideación suicida, estrés académico, insatisfacción corporal y depresión; finalmente, las variables sociodemográficas incluidas fueron: sexo, edad, horas de sueño al día y horas dedicadas al Internet o las redes sociales. Mediante tres análisis de regresión lineal múltiple, uno para cada CAR (R2 = .36, .16 y .55, respectivamente; todas con p < .001), se pudieron identificar distintas variables predictivas, entre las que destacaron la insatisfacción corporal, la depresión y el sexo (mujeres). La identificación de estas variables puede contribuir a la mejora de las estrategias de prevención en materia de CAR y, por ende, de los trastornos alimentarios entre adolescentes.
Abstract The main objective of this study was to identify sociodemographic and psychosocial variables capable of predicting risk eating behaviors (REB) in high school students. Participants were 988 adolescents (541 women and 447 men) between 14 and 18 years of age (M = 16.79, SD = 1.50). In addition to the REB (Binge-purge, Compensatory behavior and Restriction), examined through the Brief Questionnaire on Risk Food Behaviors, the following psychosocial variables were also evaluated: family and friend support, school adjustment, victimization, suicidal ideation, academic stress, body dissatisfaction and depression; finally, the sociodemographic variables included were: sex, age, hours of sleep per day and hours dedicated to the Internet or social networks. Through three multiple linear regression analyzes, one for each REB (R2 = .36, .16 and .55, respectively; all with p < .001), different predictive variables could be identified, among which stood out the body dissatisfaction, the depression and sex (women). The identification of these variables can contribute to the improvement of prevention strategies in terms of REB and eating disorders among adolescents.
