ABSTRACT
Calcium pantothenate (CAS no. 137-08-6) is the calcium salt of pantothenic acid (vitamin B5). It is used in cosmetics due to its anti-static and hair conditioning properties. A 53-year-old female nurse's aide presented with intermittent facial eruptions (Figure S1). Patch tests were positive to calcium pantothenate, an ingredient of two of her products (a cleansing milk and a facial tonic). To our knowledge, no previous cases of sensitization from calcium pantothenate have been reported except for one case of systemic dermatitis from a nutritional supplement in a dexpanthenol-sensitized patient.
Subject(s)
Cosmetics/adverse effects , Dermatitis, Allergic Contact/etiology , Facial Dermatoses/chemically induced , Pantothenic Acid/adverse effects , Vitamin B Complex/adverse effects , Delayed Diagnosis , Dermatitis, Allergic Contact/diagnosis , Facial Dermatoses/diagnosis , Female , Humans , Middle Aged , Patch TestsABSTRACT
BACKGROUND: Dermatofibrosarcoma protuberans is a rare malignant tumor with a high rate of recurrence after surgery. Moh's micrographic surgery allows examination of all surgical margins to ensure complete removal. OBJECTIVE: To evaluate the use of Moh's micrographic surgery using paraffin-embedded sections for the treatment of dermatofibrosarcoma protuberans. METHODS: We performed a retrospective analysis of 33 patients with dermatofibrosarcoma protuberans treated in our department with paraffin-embedded micrographic surgery between January 2002 and June 2015. Our cases included patients with primary untreated disease and also those with persistent disease previously treated surgically elsewhere, with histologically positive margins. RESULTS: Tumors were most commonly located on the trunk. After the first stage of micrographic surgery, including an initial lateral margin, 20 (60.6%) tumors were completely excised, 11 (33.3%) tumors required two stages and one tumor each (3.0%) required 4 and 6 stages respectively. Patients were monitored for recurrence for a mean duration of 6.5 years. There was no recurrence in any of our 33 patients. CONCLUSIONS: Our results indicate that Moh's micrographic surgery with paraffin-embedded sections may be the method of choice to treat dermatofibrosarcoma protuberans with a low recurrence rate, while preserving surrounding normal healthy tissue.
Subject(s)
Dermatofibrosarcoma/diagnosis , Dermatofibrosarcoma/surgery , Mohs Surgery/methods , Paraffin Embedding/methods , Adult , Female , Humans , Male , Middle Aged , Retrospective Studies , Treatment OutcomeABSTRACT
Introducción: Los conservantes se agregan a cosméticos, limpiadores domésticos y otros productos industriales para impedir el crecimiento de microorganismos. Desafortunadamente, pueden sensibilizar a usuarios expuestos. Material y métodos: Entre enero y junio de 2015 se analizaron las listas de los ingredientes de 2.300 productos de venta en España: 1.093 dermocosméticos, 458 productos de higiene, cosméticos y limpiadores domésticos de venta en supermercados, 636 medicamentos tópicos y 113 cosméticos de herbolario. Se evaluó la distribución de una amplia variedad de conservantes en las distintas categorías de productos. Resultados: Conservantes tales como el fenoxietanol, el ácido cítrico, el benzoato sódico y el sorbato potásico estuvieron ampliamente representados en todas las categorías de cosméticos. Se detectaron parabenos en el 16,1% de los dermocosméticos, el 14,45% de los cosméticos de supermercado, el 0,88% de los cosméticos de herbolario, el 5,18% de los medicamentos tópicos y ningún producto de limpieza. Se objetivaron isotiazolinonas en el 2,56% de los dermocosméticos, el 18% de los cosméticos de supermercado, el 7,9% de los cosméticos de herbolario, el 63,63% de los limpiadores domésticos y en ningún medicamento tópico. Contenían liberadores de formaldehído el 5,76% de los dermocosméticos, el 6,42% de los cosméticos de supermercado, el 7,96% de los cosméticos de herbolario, el 3,93% de los medicamentos tópicos y el 16,74% de los limpiadores. Conclusiones: La evaluación de la frecuencia de los conservantes en los productos de nuestro entorno permite una estimación indirecta del grado de exposición a cada uno de ellos. Se precisa impulsar medidas que conduzcan a una restricción en el uso de los conservantes más problemáticos (AU)
Introduction: Preservatives are added to cosmetic, household cleaning, and other industrial products to prevent the growth of microorganisms. Unfortunately, exposure to these substances can cause sensitization. Material and methods: Between January and June 2015, we analyzed the ingredients of 2300 products commercially available in Spain to identify the frequency of a wide variety of preservatives in different product categories. We analyzed 1093 skin care and cosmetic products sold exclusively in pharmacies (dermocosmetics), 458 household cleaning and personal hygiene and cosmetic products sold in supermarkets, 636 topical medications, and 113 cosmetic products sold in a herbal shop. Results: Phenoxyethanol, citric acid, sodium benzoate, and potassium sorbate were very common in all the cosmetic product categories. Parabens were present in 16.1% of dermocosmetic products, 14.45% of cosmetic products available in supermarkets, 0.88% of cosmetic products available in the herbal shop, 5.18% of topical medications, and in none of the cleaning products. Isothiazolinones were identified in 2.56% of dermocosmetic products, 18% of cosmetic products in supermarkets, 7.9% of cosmetic products in the herbal shop, 63.63% of household cleaners, and in none of the topical medications. Formaldehyde releasers were detected in 5.76% of dermocosmetic products, 6.42% of cosmetic products sold in supermarkets, 7.96% of cosmetic products sold in the herbal shop, 3.93% of topical medications, and 16.74% of household cleaners. Conclusions: Evaluation of the presence of preservatives in everyday products allows us to indirectly estimate exposure levels to each one. Measures restricting the use of the most problematic preservatives need to be strengthened (AU)
Subject(s)
Humans , Additives in Cosmetics , Food Preservatives/adverse effects , Parabens/adverse effects , Dermatitis, Allergic Contact/epidemiology , Sanitizing Products , Risk FactorsABSTRACT
INTRODUCTION: Preservatives are added to cosmetic, household cleaning, and other industrial products to prevent the growth of microorganisms. Unfortunately, exposure to these substances can cause sensitization. MATERIAL AND METHODS: Between January and June 2015, we analyzed the ingredients of 2300 products commercially available in Spain to identify the frequency of a wide variety of preservatives in different product categories. We analyzed 1093 skin care and cosmetic products sold exclusively in pharmacies (dermocosmetics), 458 household cleaning and personal hygiene and cosmetic products sold in supermarkets, 636 topical medications, and 113 cosmetic products sold in a herbal shop. RESULTS: Phenoxyethanol, citric acid, sodium benzoate, and potassium sorbate were very common in all the cosmetic product categories. Parabens were present in 16.1% of dermocosmetic products, 14.45% of cosmetic products available in supermarkets, 0.88% of cosmetic products available in the herbal shop, 5.18% of topical medications, and in none of the cleaning products. Isothiazolinones were identified in 2.56% of dermocosmetic products, 18% of cosmetic products in supermarkets, 7.9% of cosmetic products in the herbal shop, 63.63% of household cleaners, and in none of the topical medications. Formaldehyde releasers were detected in 5.76% of dermocosmetic products, 6.42% of cosmetic products sold in supermarkets, 7.96% of cosmetic products sold in the herbal shop, 3.93% of topical medications, and 16.74% of household cleaners. CONCLUSIONS: Evaluation of the presence of preservatives in everyday products allows us to indirectly estimate exposure levels to each one. Measures restricting the use of the most problematic preservatives need to be strengthened.
Subject(s)
Household Products/analysis , Pharmaceutical Preparations/chemistry , Preservatives, Pharmaceutical/analysis , Commerce , Cosmetics/chemistry , Formaldehyde/analysis , Parabens/analysis , Plant Preparations/chemistry , Soaps/chemistry , Thiazoles/analysisSubject(s)
Carcinoma, Transitional Cell/diagnosis , Paget Disease, Extramammary/diagnosis , Paget Disease, Extramammary/secondary , Penis/pathology , Urinary Bladder Neoplasms/diagnosis , Carcinoma, Transitional Cell/surgery , Humans , Male , Middle Aged , Paget Disease, Extramammary/surgery , Penis/surgery , Urinary Bladder Neoplasms/surgeryABSTRACT
Neonatal lupus erythematosus is an uncommon transplacentally acquired autoimmune disorder. We report a 7-month-old boy with cutaneous involvement of neonatal lupus erythematosus mimicking an extensive capillary malformation.
Subject(s)
Capillaries/abnormalities , Capillaries/pathology , Lupus Erythematosus, Systemic/congenital , Vascular Malformations/diagnosis , Biopsy , Capillaries/immunology , Diagnosis, Differential , Humans , Infant , Lupus Erythematosus, Systemic/diagnosis , Lupus Erythematosus, Systemic/immunology , Lupus Erythematosus, Systemic/pathology , MaleABSTRACT
Neonatal lupus erythematosus is an uncommon transplacentally acquired autoimmune disorder. We report a 7-month-old boy with cutaneous involvement of neonatal lupus erythematosus mimicking an extensive capillary malformation.