Subject(s)
Biliary Tract , Duodenal Ulcer , Catheterization , Duodenal Ulcer/complications , Duodenum , Humans , UlcerABSTRACT
BACKGROUND AND AIMS: The Endoscopic Resection Group of the Spanish Society of Endoscopy (GSEED-RE) model and the Australian Colonic Endoscopic Resection (ACER) model were proposed to predict delayed bleeding (DB) after EMR of large superficial colorectal lesions, but neither has been validated. We validated and updated these models. METHODS: A multicenter cohort study was performed in patients with nonpedunculated lesions ≥20 mm removed by EMR. We assessed the discrimination and calibration of the GSEED-RE and ACER models. Difficulty performing EMR was subjectively categorized as low, medium, or high. We created a new model, including factors associated with DB in 3 cohort studies. RESULTS: DB occurred in 45 of 1034 EMRs (4.5%); it was associated with proximal location (odds ratio [OR], 2.84; 95% confidence interval [CI], 1.31-6.16), antiplatelet agents (OR, 2.51; 95% CI, .99-6.34) or anticoagulants (OR, 4.54; 95% CI, 2.14-9.63), difficulty of EMR (OR, 3.23; 95% CI, 1.41-7.40), and comorbidity (OR, 2.11; 95% CI, .99-4.47). The GSEED-RE and ACER models did not accurately predict DB. Re-estimation and recalibration yielded acceptable results (GSEED-RE area under the curve [AUC], .64 [95% CI, .54-.74]; ACER AUC, .65 [95% CI, .57-.73]). We used lesion size, proximal location, comorbidity, and antiplatelet or anticoagulant therapy to generate a new model, the GSEED-RE2, which achieved higher AUC values (.69-.73; 95% CI, .59-.80) and exhibited lower susceptibility to changes among datasets. CONCLUSIONS: The updated GSEED-RE and ACER models achieved acceptable prediction levels of DB. The GSEED-RE2 model may achieve better prediction results and could be used to guide the management of patients after validation by other external groups. (Clinical trial registration number: NCT03050333.).
Subject(s)
Endoscopic Mucosal Resection , Australia , Cohort Studies , Colonoscopy , Colorectal Neoplasms/surgery , Humans , Risk FactorsABSTRACT
No disponible
Subject(s)
Humans , Female , Middle Aged , Rectovaginal Fistula/surgery , Absorbable Implants/adverse effects , Colorectal Neoplasms/surgery , Prosthesis Failure , Wound Closure Techniques/adverse effects , Postoperative Complications , Colonoscopy/methods , Device Removal/methodsABSTRACT
The case was a 52-year-old female with a rectovaginal fistula secondary to a rectosigmoid resection with low colorectal anastomosis due to adenocarcinoma. The fistula persisted after surgical reintervention with defunctionalization, a hysterectomy and colostomy in the left iliac fossa.
Subject(s)
Absorbable Implants , Postoperative Complications/therapy , Rectovaginal Fistula/therapy , Stents , Adenocarcinoma/surgery , Colorectal Neoplasms/surgery , Female , Humans , Middle Aged , Postoperative Complications/diagnostic imaging , Rectovaginal Fistula/diagnostic imagingABSTRACT
BACKGROUND & AIMS: It is not clear whether closure of mucosal defects with clips after colonic endoscopic mucosal resection (EMR) prevents delayed bleeding, although it seems to have no protective effects when risk is low. We performed a randomized trial to evaluate the efficacy of complete clip closure of large (≥2 cm) nonpedunculated colorectal lesions after EMR in patients with an estimated average or high risk of delayed bleeding. METHODS: We performed a single-blind trial at 11 hospitals in Spain from May 2016 through June 2018, including 235 consecutive patients who underwent EMR for large nonpedunculated colorectal lesions with an average or high risk of delayed bleeding (based on Spanish Endoscopy Society Endoscopic Resection Group score). Participants were randomly assigned to groups that received closure of the scar with 11-mm through-the-scope clips (treated, n = 119) or no clip (control, n = 116). The primary outcome was proportion of patients in each group with delayed bleeding, defined as evident hematochezia that required medical intervention within 15 days after colonoscopy. RESULTS: In the clip group, complete closure was achieved in 68 (57%) cases, with partial closure in 33 (28%) cases and failure to close in 18 (15%) cases. Delayed bleeding occurred in 14 (12.1%) patients in the control group and in 6 (5%) patients in the clip group (absolute risk difference, reduction of 7% in the clip group; 95% confidence interval, -14.7% to 0.3%). After completion of the clip closure, there was only 1 (1.5%) case of delayed bleeding (absolute risk difference, reduction of 10.6%; 95% confidence interval, -4.3% to 17.9%). CONCLUSIONS: In a randomized trial of patients with large nonpedunculated colorectal lesions undergoing EMR, we found that clip closure of mucosal defects in patients with a risk of bleeding can be a challenge, but also reduces delayed bleeding. Prevention of delayed bleeding required complete clip closure. ClinicalTrials.gov ID: NCT02765022.
Subject(s)
Adenocarcinoma/surgery , Adenomatous Polyps/surgery , Colonic Polyps/surgery , Colorectal Neoplasms/surgery , Endoscopic Mucosal Resection/adverse effects , Gastrointestinal Hemorrhage/prevention & control , Hemostasis, Surgical/instrumentation , Postoperative Hemorrhage/prevention & control , Surgical Instruments , Adenocarcinoma/pathology , Adenomatous Polyps/pathology , Aged , Aged, 80 and over , Colonic Polyps/pathology , Colorectal Neoplasms/pathology , Equipment Design , Female , Gastrointestinal Hemorrhage/etiology , Humans , Male , Middle Aged , Postoperative Hemorrhage/etiology , Risk Assessment , Risk Factors , Single-Blind Method , Spain , Time Factors , Treatment OutcomeABSTRACT
A 63-year-old female with a Nissen funduplication that was diagnosed nine years previously presented with abdominal pain, weight loss and occasional dysphagia of a few months duration. A computed tomography (CT) scan identified an extensive gastric tumor with a subtle curvature and cardia with distal esophagus circumferential enlargement. Gastroscopy identified gastric linitis plastica with many attached residues. The biopsy was compatible with inflammatory changes. A linear echoendoscopy identified an area at the cardia level that was compatible with a foreign body with a lineal hyperechoic irregular focus.
Subject(s)
Foreign-Body Migration/diagnosis , Fundoplication , Postoperative Complications/diagnosis , Stomach Neoplasms/diagnosis , Surgical Mesh/adverse effects , Biopsy , Endosonography , Female , Foreign-Body Migration/diagnostic imaging , Gastroscopy , Humans , Middle Aged , Postoperative Complications/diagnostic imaging , Stomach Neoplasms/diagnostic imaging , Tomography, X-Ray ComputedABSTRACT
No disponible
Subject(s)
Humans , Female , Middle Aged , Foreign-Body Migration/diagnostic imaging , Stomach Neoplasms/diagnostic imaging , Fundoplication/adverse effects , Surgical Mesh/adverse effects , Diagnosis, Differential , Postoperative Complications/diagnostic imaging , Endosonography/methodsSubject(s)
Endoscopy, Gastrointestinal/methods , Hirschsprung Disease/diagnosis , Hirschsprung Disease/pathology , Chronic Disease , Constipation/etiology , Diagnostic Techniques, Surgical , Endoscopy, Gastrointestinal/instrumentation , Female , Hirschsprung Disease/complications , Hirschsprung Disease/surgery , Humans , Young AdultABSTRACT
Este documento resume el contenido de la Guía de resección mucosa endoscópica elaborada por el grupo de trabajo de la Sociedad Española de Endoscopia Digestiva (GSEED de Resección Endoscópica) y expone las recomendaciones sobre el manejo endoscópico de las lesiones neoplásicas colorrectales superficiales (AU)
This document summarizes the contents of the Clinical Guidelines for the Endoscopic Mucosal Resection of Non-Pedunculated Colorectal Lesions that was developed by the working group of the Spanish Society of Digestive Endoscopy (GSEED of Endoscopic Resection). This document presents recommendations for the endoscopic management of superficial colorectal neoplastic lesions (AU)
Subject(s)
Humans , Colorectal Neoplasms/surgery , Endoscopy, Gastrointestinal/methods , Endoscopic Mucosal Resection/methods , Intestinal Mucosa/pathology , Peer Review , Patient Selection , Preoperative Care/methods , Colonoscopy/methodsABSTRACT
Este documento resume el contenido de la Guía de resección mucosa endoscópica elaborada por el grupo de trabajo de la Sociedad Española de Endoscopia Digestiva (GSEED de Resección Endoscópica) y expone las recomendaciones sobre el manejo endoscópico de las lesiones neoplásicas colorrectales superficiales (AU)
This document summarizes the contents of the Clinical Guidelines for the Endoscopic Mucosal Resection of Non-Pedunculated Colorectal Lesions that was developed by the working group of the Spanish Society of Digestive Endoscopy (GSEED of Endoscopic Resection). This document presents recommendations for the endoscopic management of superficial colorectal neoplastic lesions (AU)
Subject(s)
Humans , Male , Female , Endoscopic Mucosal Resection/methods , Colorectal Neoplasms/diagnostic imaging , Colorectal Neoplasms/surgery , Endoscopic Mucosal Resection/instrumentation , Endoscopic Mucosal Resection/standards , Colorectal Neoplasms/economicsABSTRACT
This document summarizes the contents of the Clinical Guidelines for the Endoscopic Mucosal Resection of Non-Pedunculated Colorectal Lesions that was developed by the working group of the Spanish Society of Digestive Endoscopy (GSEED of Endoscopic Resection). This document presents recommendations for the endoscopic management of superficial colorectal neoplastic lesions.
Subject(s)
Colorectal Neoplasms/surgery , Colorectal Surgery/methods , Endoscopic Mucosal Resection/methods , Endoscopy, Gastrointestinal/methods , Intestinal Mucosa/surgery , Colonic Diseases/surgery , Colorectal Surgery/standards , Endoscopic Mucosal Resection/standards , Endoscopy, Gastrointestinal/standards , Humans , Rectal Diseases/surgeryABSTRACT
This document summarizes the contents of the Clinical Guidelines for the Endoscopic Mucosal Resection of Non-Pedunculated Colorectal Lesions that was developed by the working group of the Spanish Society of Digestive Endoscopy (GSEED of Endoscopic Resection). This document presents recommendations for the endoscopic management of superficial colorectal neoplastic lesions.
Subject(s)
Colorectal Neoplasms/surgery , Endoscopic Mucosal Resection/standards , HumansABSTRACT
BACKGROUND & AIMS: After endoscopic mucosal resection (EMR) of colorectal lesions, delayed bleeding is the most common serious complication, but there are no guidelines for its prevention. We aimed to identify risk factors associated with delayed bleeding that required medical attention after discharge until day 15 and develop a scoring system to identify patients at risk. METHODS: We performed a prospective study of 1214 consecutive patients with nonpedunculated colorectal lesions 20 mm or larger treated by EMR (n = 1255) at 23 hospitals in Spain, from February 2013 through February 2015. Patients were examined 15 days after the procedure, and medical data were collected. We used the data to create a delayed bleeding scoring system, and assigned a weight to each risk factor based on the ß parameter from multivariate logistic regression analysis. Patients were classified as being at low, average, or high risk for delayed bleeding. RESULTS: Delayed bleeding occurred in 46 cases (3.7%, 95% confidence interval, 2.7%-4.9%). In multivariate analysis, factors associated with delayed bleeding included age ≥75 years (odds ratio [OR], 2.36; P < .01), American Society of Anesthesiologist classification scores of III or IV (OR, 1.90; P ≤ .05), aspirin use during EMR (OR, 3.16; P < .05), right-sided lesions (OR, 4.86; P < .01), lesion size ≥40 mm (OR, 1.91; P ≤ .05), and a mucosal gap not closed by hemoclips (OR, 3.63; P ≤ .01). We developed a risk scoring system based on these 6 variables that assigned patients to the low-risk (score, 0-3), average-risk (score, 4-7), or high-risk (score, 8-10) categories with a receiver operating characteristic curve of 0.77 (95% confidence interval, 0.70-0.83). In these groups, the probabilities of delayed bleeding were 0.6%, 5.5%, and 40%, respectively. CONCLUSIONS: The risk of delayed bleeding after EMR of large colorectal lesions is 3.7%. We developed a risk scoring system based on 6 factors that determined the risk for delayed bleeding (receiver operating characteristic curve, 0.77). The factors most strongly associated with delayed bleeding were right-sided lesions, aspirin use, and mucosal defects not closed by hemoclips. Patients considered to be high risk (score, 8-10) had a 40% probability of delayed bleeding.
Subject(s)
Decision Support Techniques , Endoscopic Mucosal Resection/adverse effects , Gastrointestinal Hemorrhage/diagnosis , Gastrointestinal Hemorrhage/pathology , Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Prospective Studies , Risk Assessment , Spain , Young AdultSubject(s)
Cholangiopancreatography, Endoscopic Retrograde/adverse effects , Cholangiopancreatography, Endoscopic Retrograde/instrumentation , Duodenal Diseases/therapy , Intestinal Perforation/therapy , Aged, 80 and over , Duodenal Diseases/etiology , Duodenoscopes , Humans , Intestinal Perforation/etiology , Male , Surgical InstrumentsABSTRACT
No disponible
Subject(s)
Humans , Male , Aged, 80 and over , Foreign-Body Migration/diagnosis , Zenker Diverticulum/complications , Capsule Endoscopes , Risk FactorsABSTRACT
No disponible
