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1.
Arch. Soc. Esp. Oftalmol ; 91(11): 551-555, nov. 2016. ilus
Article in Spanish | IBECS | ID: ibc-157165

ABSTRACT

CASO CLÍNICO: Presentamos el caso de un varón de 55 años, con un adenocarcinoma no microcítico de pulmón, que comenzó con una metástasis coroidea. El paciente mostraba disminución de la agudeza visual. El examen reveló una metástasis coroidea unilateral secundaria al tumor. Tras el tratamiento con afatinib, se consiguió la regresión completa. DISCUSIÓN: Las metástasis coroideas pueden ser la primera manifestación de un cáncer de pulmón. De ahí la importancia de una evaluación completa en pacientes con tumores coroideos. El afatinib se mostró efectivo en el tratamiento de las metástasis coroideas de un carcinoma de pulmón con mutación EFGR


CASE REPORT: We present the case of a 55-year-old man with a non-small cell lung adenocarcinoma, who presented with choroidal metastasis. The patient showed a decrease in visual acuity. His evaluation revealed unilateral choroidal metastasis secondary to carcinoma of the lung. The patient received afatinib with complete regression of choroidal metastasis after one year follow-up. DISCUSSION: Choroidal metastasis may be the initial sign of lung cancer. This case highlights the importance of a thorough systemic evaluation in patients with choroidal tumours. Afatinib was effective against choroidal metastasis of a lung adenocarcinoma with EFGR mutation


Subject(s)
Humans , Male , Middle Aged , Lung Neoplasms/diagnosis , Choroid Neoplasms/secondary , Protein Kinase Inhibitors/therapeutic use , Adenocarcinoma/diagnosis , Neoplasm Metastasis/pathology , Carcinoma, Non-Small-Cell Lung/diagnosis , Mutation , Lung Neoplasms/drug therapy
2.
Arch Soc Esp Oftalmol ; 91(11): 551-555, 2016 Nov.
Article in English, Spanish | MEDLINE | ID: mdl-27046001

ABSTRACT

CASE REPORT: We present the case of a 55-year-old man with a non-small cell lung adenocarcinoma, who presented with choroidal metastasis. The patient showed a decrease in visual acuity. His evaluation revealed unilateral choroidal metastasis secondary to carcinoma of the lung. The patient received afatinib with complete regression of choroidal metastasis after one year follow-up. DISCUSSION: Choroidal metastasis may be the initial sign of lung cancer. This case highlights the importance of a thorough systemic evaluation in patients with choroidal tumours. Afatinib was effective against choroidal metastasis of a lung adenocarcinoma with EFGR mutation.


Subject(s)
Adenocarcinoma/secondary , Antineoplastic Agents/therapeutic use , Carcinoma, Non-Small-Cell Lung/secondary , Choroid Neoplasms/secondary , Lung Neoplasms/diagnosis , Protein Kinase Inhibitors/therapeutic use , Quinazolines/therapeutic use , Adenocarcinoma/diagnosis , Adenocarcinoma/drug therapy , Adenocarcinoma/enzymology , Adenocarcinoma of Lung , Afatinib , Antineoplastic Agents/pharmacology , Carcinoma, Non-Small-Cell Lung/diagnosis , Carcinoma, Non-Small-Cell Lung/drug therapy , Carcinoma, Non-Small-Cell Lung/enzymology , Choroid Neoplasms/diagnosis , Choroid Neoplasms/drug therapy , Choroid Neoplasms/enzymology , ErbB Receptors/antagonists & inhibitors , Humans , Lung Neoplasms/drug therapy , Lung Neoplasms/enzymology , Male , Middle Aged , Neoplasm Proteins/antagonists & inhibitors , Protein Kinase Inhibitors/pharmacology , Quinazolines/pharmacology , Remission Induction , Signal Transduction/drug effects
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