ABSTRACT
Schwannomas are tumors of nerve sheath origin, the lesion being derived from the Schwann cells surrounding neural tissue in most of the peripheral, cranial and autonomic nerves. Schwannomas occurring in the head and neck represent 25-35% of all reported schwannomas, and most commonly arise from the acoustic or the neumogastric nerves. In the nose and paranasal sinuses these tumors are very uncommon (fewer than 4% of all schwannomas). In the pterygopalatine fossa they are very rare, and arise in this case from the ophthalmic and maxillary branches of the trigeminal nerve. In this exceptional site, the tumor is classically approached through a Caldwell-Luc incision. In this case, we report the removal of a schwannoma of the pterygopalatine fossa by endoscopic sinus surgery.
Subject(s)
Endoscopy/methods , Neurilemmoma/pathology , Neurilemmoma/surgery , Paranasal Sinus Neoplasms/pathology , Paranasal Sinus Neoplasms/surgery , Adult , Humans , Magnetic Resonance Imaging , MaleABSTRACT
Los schwannomas son tumores que derivan de las células de Schwann que forman la vaina de mielina que rodea a la mayoría de nervios periféricos, autónomos y pares craneales. Los schwannomas de cabeza y cuello representan el 25-35% de todos los del organismo y se localizan referentemente en los pares craneales VIII y X. En las fosas nasales y senos paranasales son bastante raros (menos del 4% de todo el organismo). Con menor frecuencia aún se presenta este tumor en el espacio pterigo-palatino, teniendo origen en este caso en las ramas 2ª ó 3ª del trigémino. En esta excepcional localización, el abordaje utilizado ha sido clásicamente un Cadwell-Luc. En este caso describimos la exéresis de un tumor de estas características mediante un abordaje endoscópico intranasal
Schwannomas are tumors of nerve sheath origin, the lesion being derived from the Schwann cells surrounding neural tissue in most of the peripheral, cranial and autonomic nerves. Schwannomas occurring in the head and neck represent 25-35% of all reported schwannomas, and most commonly arise from the acoustic or the neumogastric nerves. In the nose and paranasal sinuses these tumors are very uncommon (fewer than 4% of all schwannomas). In the pterygopalatine fossa they are very rare, and arise in this case from the ophthalmic and maxillary branches of the trigeminal nerve. In this exceptional site, the tumor is classically approached through a Caldwell-Luc incision. In this case, we report the removal of a schwannoma of the pterygopalatine fossa by endoscopic sinus surgery
Subject(s)
Male , Humans , Endoscopy/methods , Neurilemmoma/pathology , Neurilemmoma/surgery , Paranasal Sinus Neoplasms/pathology , Paranasal Sinus Neoplasms/surgery , Magnetic Resonance ImagingABSTRACT
Presentamos el caso de un varón de 65 años con un angiomioma del espacio retrofaríngeo. El angiomioma es un tumor que se origina en el músculo liso de la pared de los vasos sanguíneos. Es un tipo de tumor relativamente raro en cabeza y cuello, especialmente en localizaciones profundas. Este es el segundo caso descrito de angiomioma en el espacio retrofaríngeo. Aunque los estudios de imagen y la punción-aspiración con aguja fina (PAAF) apuntan hacia un tumor de origen vascular, el diagnóstico de esta lesión se realiza sólo mediante biopsia excisional y tinción con vimentina, desmina, actina o miosina. El tratamiento consiste en resección quirúrgica, y la recurrencia del tumor tras ello es excepcional (AU)
We report the case of a 65-year-old male patient with an angiomyoma of the retropharyngeal space. Angiomyoma is a tumour that arises from the smooth muscle in the wall of blood vessels. It is a relatively rare tumour of the head and neck, mostly in deep locations. This one is the second reported angiomyoma of the retropharyngeal space. Although image examinations and fine needle aspiration (FNA) did point to a vascular tumour, the diagnosis of this lesion is made by on excisional biopsy and histological staining with vimentin, desmin, actin or myosin. The treatment is excision of the tumour and recurrence is exceptional (AU)
Subject(s)
Male , Aged , Humans , Angiomyoma/diagnosis , Head and Neck Neoplasms/surgery , Angiomyoma/surgery , Head and Neck Neoplasms/diagnosis , PharynxABSTRACT
We report the case of a 65-year-old male patient with an angiomyoma of the retropharyngeal space. Angiomyoma is a tumour that arises from the smooth muscle in the wall of blood vessels. It is a relatively rare tumour of the head and neck, mostly in deep locations. This one is the second reported angiomyoma of the retropharyngeal space. Although image examinations and fine needle aspiration (FNA) did point to a vascular tumour, the diagnosis of this lesion is made by on excisional biopsy and histological staining with vimentin, desmin, actin or myosin. The treatment is excision of the tumour and recurrence is exceptional.
Subject(s)
Angiomyoma , Head and Neck Neoplasms , Aged , Angiomyoma/diagnosis , Angiomyoma/surgery , Head and Neck Neoplasms/diagnosis , Head and Neck Neoplasms/surgery , Humans , Male , PharynxABSTRACT
Human papillomavirus integration in cellular DNA and loss of heterozygosity of P53 gene are both related with tumour formation process by promoting genomic instability that leads to DNA abnormalities accumulation. In order to analyze the relationship between both events, 26 squamous cell carcinomas of the head and neck were studied. HPV 16 and 6b DNA was detected by PCR in 8 cases (31%), whereas P53 loss of heterozygosity was present in 16 cases (61%). No correlation was found between both events and they were not related to clinical factors neither the prognosis. Consequently, HPV integration and loss of heterozygosity of P53 seem to act independently in the genesis of these tumours.
Subject(s)
Carcinoma, Squamous Cell/genetics , Genes, p53/genetics , Head and Neck Neoplasms/genetics , Loss of Heterozygosity , Papillomaviridae/genetics , Virus Integration , Adult , Aged , Carcinoma, Squamous Cell/pathology , Gene Silencing , Head and Neck Neoplasms/pathology , Humans , Male , Middle Aged , Papillomaviridae/physiologyABSTRACT
La integración del virus del papiloma humano (HPV) en el genoma celular y la pérdida de heterozigosidad del gen P53 son ambos fenómenos relacionados con el proceso de la carcinogénesis a través de la inducción de una inestabilidad genética que favorece el acúmulo de anomalías en el ADN. Con el fin de analizar la posible asociación entre estos dos eventos, estudiamos un grupo de 26 pacientes intervenidos de carcinoma epidermoide de cabeza y cuello. Se demostró la integración de los HPV 16 y 6b mediante PCR en 8 casos (31 por ciento), mientras que la pérdida de heterozigosidad del P53apareció en 16 pacientes (61 por ciento). No se encontró una asociación significativa entre ambos fenómenos, ni se halló que estuvieran correlacionados con factores clínicos ni con el pronóstico. Por lo tanto, la integración del HPV y la pérdida de heterozigosidad del P53son factores que parecen actuar independientemente en la producción de estos tumores (AU)
Human papillomavirus integration in cellular DNA and loss of heterozygosity of P53 gene are both related with tumour formation process by promoting genomic instability that leads to DNA abnormalities accumulation. In order to analyze the relationship between both events, 26 squamous cell carcinomas of the head and neck were studied. HPV 16 and 6b DNA was detected by PCR in 8 cases (31%), whereas P53 loss of heterozygosity was present in 16 cases (61%). No correlation was found between both events and they were not related to clinical factors neither the prognosis. Consequently, HPV integration and loss of heterozygosity of P53 seem to act independently in the genesis of these tumours (AU)
Subject(s)
Middle Aged , Adult , Aged , Male , Humans , Virus Integration , Loss of Heterozygosity , Genes, p53/genetics , Carcinoma, Squamous Cell/genetics , Papillomaviridae/genetics , Gene Silencing , Head and Neck NeoplasmsABSTRACT
The presence of subharmonics in abnormal adult voices (polyps, polypoid degeneration, plicae ventricularis) was investigated. Subharmonics are low-frequency modulations located between two consecutive harmonics in the spectrum. Spectrum analysis was performed on 115 abnormal voices, of which 36 (31%) had subharmonics. Thirteen of the 36 voices with subharmonics had normal jitter and shimmer, so the rough voice was characterized acoustically not only by jitter and shimmer but by the presence of subharmonics in the spectrum. Subharmonics may correspond to a qualitative change in the behavior of the vibratory system.
Subject(s)
Sound Spectrography/methods , Voice Disorders/diagnosis , Adult , Hoarseness/diagnosis , Humans , Speech/physiology , Voice Disorders/etiology , Voice QualityABSTRACT
Este estudio investiga la presencia de subarmónicos en voces adultas patológicas (pólipos, edema de Reinke, disfonía ventricular). Los subarmónicos son trazados de baja frecuencia localizados entre dos armónicos consecutivos en el espectrograma. Se realizó un espectrograma en 115 voces patológicas, 36 de las cuales presentaron subarmónicos (31 por ciento). 13 de las 36 voces con subarmónicos presentaban valores normales de jitter y shimmer, por lo que la voz áspera se caracteriza acústicamente no sólo por las alteraciones deljittery shimmer sino tambiénpor la presencia de subarmónicos en el espectro. Los subarmónicos pueden corresponder a un cambio cualitativo en la conducta del sistema vibratorio (AU)
The presence of subharmonics in abnormal adult voices (polyps, polypoid degeneration, plicae ventricularis) was investigated. Subharmonics are low-frequency modulations located between two consecutive harmonics in the spectrum. Spectrum analysis was performed on 115 abnormal voices, of which 36 (31%) had subharmonics. Thirteen of the 36 voices with subharmonics had normal jitter and shimmer, so the rough voice was characterized acoustically not only by jitter and shimmer but by the presence of subharmonics in the spectrum. Subharmonics may correspond to a qualitative change in the behavior of the vibratory system (AU)
