Subject(s)
Glomerulonephritis, IGA/genetics , Glomerulonephritis, IGA/surgery , Kidney Transplantation , Tissue Donors , Adolescent , Adult , Family , Female , Glomerular Mesangium/immunology , Glomerular Mesangium/pathology , Glomerulonephritis, IGA/pathology , Humans , Immunoglobulin A/analysis , Kidney Transplantation/pathology , Male , Middle AgedABSTRACT
Seventy donor kidneys for transplant were studied with light microscopy (LM), electron microscopy (EM) and immunofluorescence (IM) for C3, C4, Clq, IgG, IgA, IgE, IgM, and antifibrin; the samples were taken just before transplanting the allograft kidney. Glomerular changes were found in 35.7% of apparently normal living donors: 9 cases showed relative glomerular ischemia with an irregular basal membrane (12.9%); 5 cases showed a diffusely widened basal membrane without antecedents of hyperglycemia (7.1%); in one case (1.4%) there was a lesion similar to type 1 mesangio-capillary glomerulonephritis with C3++, IgG++, IgA+, and IgM+; in another case (1.4%) there were scant isolated C3 glomerular, subepithelial deposits with indentation of the basement membrane of the immunocomplex type with a microhematuria which was demonstrated only after donation, and in 9 cases (among them two pairs of siblings) there were mesangial IgA and mesangial electron-dense deposits compatible with Berger's disease (12.9%). None of these glomerulopathies were evident under LM.
Subject(s)
Kidney Transplantation , Kidney/pathology , Tissue Donors , Adolescent , Adult , Basement Membrane/ultrastructure , Biopsy , Female , Fluorescent Antibody Technique , Glomerular Mesangium/metabolism , Glomerulonephritis/pathology , Humans , Immune Complex Diseases/pathology , Immunoglobulin A/metabolism , Ischemia/pathology , Kidney/ultrastructure , Kidney Glomerulus/blood supply , Male , Microscopy, Electron , Middle AgedABSTRACT
Se revisó las características histológicas y clínicas de 27 casos de carcinoma adenoideoquístico (CAQ), de las glándulas salivales mayores y menores. Hubo 13 casos en glándulas salivales mayores (8 submaxilares) y 14 en las menores (4 palatinas). Se reclasificó los tumores en tres grados de malignidad creciente: Grado I: tumores tubulares y cribiformes sin áreas sólidas (14 casos); Grado II: tumores tubulares y cribiformes con menos de 30% de áreas sólidas (8 casos); Grado III: tumores con más de 30% de áreas sólidas (5 casos). Los tumores grado I fueron más pequeños (2,5 cm), predominantemente cribiformes, sin componente sólido, más susceptibles de escisión quirúrgica adecuada y tuvieron un curso clínico prolongado. Los tumores grado II tuvieron 10,62% de áreas sólidas y los grados III, 55,2% de dichas áreas, fueron más grandes (3,7 y 4,8 cm), recurrieron con mayor frecuencia y tuvieron un curso clínico agresivo con muerte del paciente al cabo de 3-4 años. El grado histológico y el tamaño del tumor fueron los parámetros que mejor correlacionaron con la evolución y pronóstico de nuestros pacientes
