ABSTRACT
Recurrent respiratory papillomatosis can be a devastating condition for a child, with severe consequences. Currently, there is no proven successful medical treatment. We describe the use of systemic bevacizumab to treat two children affected by aggressive recurrent respiratory papillomatosis. Respiratory symptoms and quality of life improved dramatically in both patients, without observing any toxicity. The only complication was mild proteinuria. Systemic bevacizumab is a promising adjuvant treatment in aggressive recurrent respiratory papillomatosis in children. It is effective and well tolerated. Further studies are needed to establish the optimal dosing frequency and duration of therapy. Laryngoscope, 129:1001-1004, 2019.
Subject(s)
Angiogenesis Inhibitors/therapeutic use , Bevacizumab/therapeutic use , Papillomavirus Infections/drug therapy , Respiratory Tract Infections/drug therapy , Angiogenesis Inhibitors/adverse effects , Bevacizumab/adverse effects , Child , Female , Humans , MaleABSTRACT
INTRODUCTION: Bone metastasis is the most common cause of cancer-related pain, and metastatic bone pain (MBP) is not only severe but also progressive in many patients. The aim of this study was to investigate the association between pain management and performance status in patients with metastatic bone cancer in the Spanish clinical setting. METHODS: A 3-month follow-up prospective, epidemiologic, multicenter study was conducted in 579 patients to assess the evolution of their performance, the impact of pain control on sleep and functionality, and the degree of pain control according to analgesic treatment. RESULTS: In patients with MBP, Eastern Cooperative Oncology Group (ECOG) status (1.5 ± 0.7-1.3 ± 0.7 and 1.3 ± 0.8; p < 0.001) and pain (6.5 ± 1.4-2.8 ± 1.9 and 2.1 ± 1.9; p < 0.001) improved significantly from baseline to months 1 and 3, as did functionality and sleep, after a treatment change consisting of increasing the administration of opioids. Evolution of ECOG and pain were closely related. ECOG and pain outcomes were significantly more favorable in patients treated with opioids versus non-opioid treatment, and in patients who did not need rescue medication versus those who did. CONCLUSIONS: MBP is currently poorly managed in Spain. ECOG improvement is closely and directly related to pain management in MBP. Opioid treatment and a lack of requirements for rescue medication are associated with better ECOG and pain outcomes in MBP patients. FUNDING: Mundipharma Pharmaceuticals S.L.
Subject(s)
Bone Neoplasms/secondary , Cancer Pain/therapy , Health Status , Pain Management/methods , Aged , Analgesics/therapeutic use , Analgesics, Opioid/therapeutic use , Cancer Pain/drug therapy , Female , Humans , Male , Middle Aged , Prospective Studies , SpainABSTRACT
Two groups of women were assessed in psychological aspects considered by some authors of interest for personal well-being. The sample consisted of 118 women, 58 diagnosed with breast cancer and 60 healthy women, of similar ages and personal circumstances. The purpose of the study was: (a) to explore the existence of stressful life events in the women's history and their degree of subjective distress and (b) to determine whether or not there is an emotional avoidance style in the group of women with breast cancer. The following assessment instruments were employed: the "Cuestionario de Formas de Afrontamiento" (CEA), the Five-Factor Inventory NEO-PI-R, and the State-Trait Anger Inventory (STAXI). The results revealed more stressful vital events in the last two years in the group of women with breast cancer and significant differences in the degree of current distress. They also obtained higher scores in current anger, resignation, and neuroticism.
Subject(s)
Avoidance Learning , Breast Neoplasms/psychology , Defense Mechanisms , Emotions , Life Change Events , Adaptation, Psychological , Adult , Female , Humans , Middle Aged , Personality Inventory/statistics & numerical data , Psychometrics , Repression, PsychologyABSTRACT
Two groups of women were assessed in psychological aspects considered by some authors of interest for personal well-being. The sample consisted of 118 women, 58 diagnosed with breast cancer and 60 healthy women, of similar ages and personal circumstances. The purpose of the study was: (a) to explore the existence of stressful life events in the womens history and their degree of subjective distress and (b) to determine whether or not there is an emotional avoidance style in the group of women with breast cancer. The following assessment instruments were employed: the «Cuestionario de Formas de Afrontamiento» (CEA), the Five-Factor Inventory NEOPI-R, and the State-Trait Anger Inventory (STAXI). The results revealed more stressful vital events in the last two years in the group of women with breast cancer and significant differences in the degree of current distress. They also obtained higher scores in current anger, resignation, and neuroticism (AU)
Se ha realizado una evaluación de aspectos psicológicos a un grupo de 118 mujeres; 58 diagnosticadas de cáncer de mama y 60 mujeres sanas, de edades y situación personal similares. El estudio tiene como objetivos evaluar en la historia de las mujeres con cáncer de mama y comparar con el grupo de mujeres sanas: (a) la existencia de estresores vitales y su grado de malestar subjetivo y (b) rasgos de personalidad considerados característicos de un estilo de evitación emocional. Los instrumentos de evaluación utilizados son: el Cuestionario de Formas de Afrontamiento (CEA), el Inventario de CincoFactores NEO-PI-R, y el Inventario Rasgo-Estado de Ira (STAXI). Los resultados encuentran, en el grupo de mujeres con cáncer de mama, mayor proporción de situaciones vitales estresantes durante los dos últimos años y diferencias significativas en el grado de malestar actual. También puntuaron más alto en las variables ira actual, resignación y neuroticismo (AU)
