Subject(s)
Antibodies, Monoclonal, Humanized/therapeutic use , Antiphospholipid Syndrome/drug therapy , Complement Inactivating Agents/therapeutic use , Multiple Organ Failure/therapy , Antibodies, Anticardiolipin/immunology , Anticoagulants/therapeutic use , Antiphospholipid Syndrome/complications , Antiphospholipid Syndrome/genetics , Antiphospholipid Syndrome/immunology , Blood Proteins/genetics , Brachiocephalic Veins/diagnostic imaging , Bronchiolitis, Viral/complications , Complement C3b Inactivator Proteins/genetics , Computed Tomography Angiography , Continuous Renal Replacement Therapy , Evoked Potentials, Visual , Humans , Infant , Intensive Care Units, Pediatric , Jugular Veins/diagnostic imaging , Male , Multiple Organ Failure/etiology , Plasma Exchange , Respiratory Syncytial Virus Infections/complications , Sequence Deletion , Sinus Thrombosis, Intracranial/diagnostic imaging , Sinus Thrombosis, Intracranial/etiology , Thrombocytopenia/blood , Thrombocytopenia/drug therapy , Thrombocytopenia/etiology , Thrombophilia/blood , Thrombophilia/etiology , Thrombophilia/therapy , Vasoconstrictor Agents/therapeutic use , Venous Thrombosis/diagnostic imaging , Venous Thrombosis/etiology , Water-Electrolyte Imbalance/etiologyABSTRACT
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Subject(s)
Humans , Infant, Newborn , Infant , Congenital Hyperinsulinism/diagnosis , Congenital Hyperinsulinism/genetics , Hypoglycemia/diagnosis , Hypoglycemia/genetics , Genetic HeterogeneityABSTRACT
OBJECTIVE: Hypercalciuria is a common lithogenic risk factor. The aim of this study was, first, to study the characteristics of urine biochemical factors of children with hypercalciuria (HC) and compare them with those of children without hypercalciuria. Second, to analyze the differences between children with HC and lithiasis (HCL) and children with HC and no lithiasis (HCNL). METHODS: The sample was composed by 111 cases with HC, divided into 2 groups: HCNL group, consisting of 93 cases with no personal history of kidney stones, and HCL group, 18 cases with personal history of kidney stones. As a cohort control group, 113 healthy children were used. Creatinine, urea, sodium, potassium, chlorine, uric acid, calcium, phosphorus, magnesium and osmolality: blood and 24-hour urine following parameters were determined. Oxalate and citrate were determined in urine. RESULTS: The mean values of natriuresis, uricosuria, phosphaturia, magnesuria, citraturia, calcium oxalate and calcium phosphate saturation were higher in HCNL than in control group. The HCL group had phosphaturia, calcium oxalate and calcium phosphate saturations more elevated compared with the control group. There were no significant differences in urinary excretion of various parameters when the groups HCL and HCNL were compared. CONCLUSIONS: Our results show that children with hypercalciuria without lithiasis associated show an increase in natriuresis, phosphaturia, uricosuria, magnesuria and citraturia. We found no differences between these urinary abnormalities when compared hypercalciuric children without lithiasis with those with hypercalciuria and urolithiasis.
Subject(s)
Hypercalciuria/urine , Kidney Calculi/urine , Adolescent , Chemical Phenomena , Child , Child, Preschool , Female , Humans , Male , Retrospective StudiesABSTRACT
OBJETIVO: La hipercalciuria constituye un factor de riesgo litógeno frecuente. El objetivo de este estudio ha sido, en primer lugar, examinar las características de los factores bioquímicos que componen la orina de los niños con hipercalciuria (HC) y compararlas con las de niños normales. En segundo lugar, analizar las diferencias que presentan los niños con hipercalciuria y litiasis (HCL) de los niños con hipercalciuria sin litiasis (HSL) MÉTODOS: Muestra constituida por 111 casos con HC, divididos en 2 grupos: grupo HSL, compuesto por 93 casos sin historia personal de litiasis renal, grupo HCL, 18 casos con historia personal de litiasis renal. Como grupo control se utilizó una cohorte de 113 niños sanos. En sangre y en orina de 24 horas se determinaron los siguientes parámetros: creatinina, urea, sodio, potasio, cloro, ácido úrico, calcio, fósforo, magnesio y osmolalidad. En la orina se determinó oxalato y citrato. RESULTADOS: En comparación con el grupo control, los valores medios de la natriuresis, uricosuria, fosfaturia, magnesuria, citraturia, saturación de sales oxalato cálcico y saturación de fosfato cálcico estaban más elevados en las HSL. El grupo HCL presentaba la fosfaturia, saturación de oxalato cálcico y fosfato cálcico más elevadas en comparación con el grupo control. No había diferencias significativas en la excreción urinaria de los distintos parámetros cuando se compararon los grupos HSL y HCL. CONCLUSIONES: Nuestros resultados muestran que en los niños con hipercalciuria sin litiasis asociada existe una elevación en la excreción renal de sodio, ácido úrico, magnesio, y citrato. No encontramos diferencias entre estas anomalías urinarias cuando comparamos los casos con hipercalciuria sin litiasis de aquellos que presentan hipercalciuria y litiasis asociada
OBJECTIVE: Hypercalciuria is a common lithogenic risk factor. The aim of this study was, first, to study the characteristics of urine biochemical factors of children with hypercalciuria (HC) and compare them with those of children without hypercalciuria. Second, to analyze the differences between children with HC and lithiasis (HCL) and children with HC and no lithiasis (HCNL). METHODS: The sample was composed by 111 cases with HC, divided into 2 groups: HCNL group, consisting of 93 cases with no personal history of kidney stones, and HCL group, 18 cases with personal history of kidney stones. As a cohort control group, 113 healthy children were used. Creatinine, urea, sodium, potassium, chlorine, uric acid, calcium, phosphorus, magnesium and osmolality: blood and 24-hour urine following parameters were determined. Oxalate and citrate were determined in urine. RESULTS: The mean values of natriuresis, uricosuria, phosphaturia, magnesuria, citraturia, calcium oxalate and calcium phosphate saturation were higher in HCNL than in control group. The HCL group had phosphaturia, calcium oxalate and calcium phosphate saturations more elevated compared with the control group. There were no significant differences in urinary excretion of various parameters when the groups HCL and HCNL were compared. CONCLUSIONS: Our results show that children with hypercalciuria without lithiasis associated show an increase in natriuresis, phosphaturia, uricosuria, magnesuria and citraturia. We found no differences between these urinary abnormalities when compared hypercalciuric children without lithiasis with those with hypercalciuria and urolithiasis
Subject(s)
Humans , Child , Urinalysis/methods , Hypercalciuria/urine , Nephrolithiasis/physiopathology , 24965/methods , Nephrolithiasis/epidemiology , Risk Factors , Calcium Oxalate/analysis , Calcium Citrate/analysis , Case-Control Studies , Retrospective Studies , Age and Sex Distribution , Kidney Function TestsABSTRACT
Polyarteritis nodosa (PAN) is a non-frequent vasculitis of small- and medium-sized vessels. Psoriatic arthritis (PA) is described as a "unique inflammatory arthritis associated with psoriasis" with an inexact prevalence rate due to the lack of widely accepted classification criteria. We describe the case of an 11-year-old boy that presented with fever of unknown origin plus clinical signs of sacroiliitis, bilateral enthesitis of the plantar fascia, and skin psoriasis. He acutely developed erythematous and tender nodular lesions in the lower limbs that lasted around 3 weeks and spontaneously disappeared at the same time as the fever. He was diagnosed as having PAN and PA according to clinical and histological criteria. This is the first report of the coexistence of PAN and PA in a child indicating a possible relation (maybe cross-reactivity of an infectious agent) between PAN and spondiloarthritis.