ABSTRACT
Enchondromatosis of the hand in the context of the Oilier disease is an infrequent pathologie associated with a high rate of malignancy. In this work, we present a case with multiple enchondromas affecting mainly the fourth and fifth rays of the hand, and with multiple ipsilateral lesions in the foot, sacroiliac joint and iliac bone. This patient is, in addition, an unusual case for a long-term progression (28 years), serious deforming appearance and for the double malignant degeneration to chondrosarcoma of the affected fingers. Clinical features, tumor factors, criterion of diagnosis and prognosis, surgical strategy and follow-up evaluation are analysed, as well as a review of the literature.
Subject(s)
Bone Neoplasms/etiology , Bone Neoplasms/pathology , Chondrosarcoma/etiology , Chondrosarcoma/pathology , Enchondromatosis/complications , Hand Deformities, Acquired/pathology , Bone Neoplasms/surgery , Chondrosarcoma/surgery , Disease Progression , Female , Hand Deformities, Acquired/surgery , Humans , Middle Aged , Prognosis , Time FactorsABSTRACT
Introducción: Se presenta un caso de tumor de partes blandas de patrón epitelioide, con rasgos clínicos, histológicos e inmunohistoquímicos acordes con la recientemente descrita "variante proximal" de sarcoma epitelioide. Material y métodos: Un varón de 28 años debuta con un tumor profundo localizado en la región perineal. Resultados: Microscópicamente, mostró hábito epitelioide, con marcada atipia citológica y frecuentes rasgos rabdoides, siendo el patrón de inmunoreactividad superponible al del sarcoma epitelioideclásico. Conclusiones: Ante un tumor con rasgos intermedios entre un sarcoma epitelioide clásico, un tumor rabdoide y un carcinoma indiferenciado, hay que pensar en la variante proximal del sarcoma epitelioide (AU)
Subject(s)
Adult , Male , Humans , Sarcoma/diagnosis , Sarcoma/pathology , Immunohistochemistry/methods , Perineum/pathology , Sarcoma, Clear Cell/diagnosis , Sarcoma, Clear Cell/pathology , Retroperitoneal Neoplasms/complications , Retroperitoneal Neoplasms/diagnosis , Retroperitoneal Neoplasms/epidemiology , Retroperitoneal Neoplasms/pathology , Sarcoma , Sarcoma/ultrastructureABSTRACT
Sinus histiocytosis with massive lymphadenopathy (SHML) is a rare entity characterized by the proliferation of cells belonging to the macrophage-histiocyte family, but whose exact origin is unknown. A case of SHML occurring in a 62-yr-old female is described in which the diagnosis is initially suggested by fine-needle aspiration (FNA) of a cervical node. The smears show a background of lymphocytes and plasma cells and large histiocytes with well-preserved lymphocytes in their cytoplasm (emperipolesis or lymphophagocytosis). Both nodal and extranodal (nasal mass) involvement are confirmed by surgical biopsy. The immunohistochemistry suggests that SHML cells are functionally activated macrophages. Eight months after diagnosis, the patient is clinically well, with partial improvement of lymphadenopathy.
Subject(s)
Biopsy, Needle , Histiocytosis, Sinus/pathology , Lymph Nodes/pathology , Nose/pathology , Cell Nucleus/pathology , Coloring Agents , Cytoplasm/pathology , Female , Histiocytes/pathology , Humans , Immunohistochemistry , Lymphocytes/pathology , Middle Aged , Neutrophils/pathology , Plasma Cells/pathologyABSTRACT
Salivary gland oncocytomas are very rare tumors with very few malignant cases reported in the literature. We present in this work a malignant oncocytoma of the parotid gland, and make a summary of all the accepted criteria in the reviewed publications as definitive of oncocytoma and malignant oncocytoma of the salivary gland, and furthermore we make a differential diagnosis with other neoplasms.
Subject(s)
Adenoma/pathology , Parotid Neoplasms/pathology , Adenoma/diagnosis , Adenoma/ultrastructure , Aged , Diagnosis, Differential , Humans , Male , Parotid Neoplasms/diagnosis , Parotid Neoplasms/ultrastructureABSTRACT
An apparently normal 10-day-old girl had, since birth, a gray-white vascularized tumor in the inferior quadrants of the right anterior chamber. General physical examination revealed abdominal distension, hepatomegaly, splenomegaly, and a deeply located abdominal mass. Multiple subcutaneous nodules scattered all around the body's surface could be palpated. Surgical exploration confirmed the presence of a left adrenal neuroblastoma. Six months after a complete resection of the abdominal tumor and general radiotherapy and chemotherapy, the right anterior chamber mass regressed almost completely, leaving only a calcified residue. The child is living and well six years after the diagnosis of neuroblastoma. This is the first case known to us in the literature of a congenital anterior chamber metastasis, as well as the first case reported of an anterior segment metastasis from a neuroblastoma.
