ABSTRACT
AIM: This study aimed to report a case of vitreous and optic nerve infiltration of a primary adrenal B lymphoma. CASE REPORT: An 81-year-old patient consulted for decrease in vision in the left eye and pain with ocular movements during the last week. The patient was being treated with chemotherapy for an adrenal gland diffuse large B-cell lymphoma. On examination, vitritis was seen in both eyes and optic disc edema in his left eye. After an extensive study based on orbital and brain magnetic resonance imaging and vitreous cytology, an ocular infiltration by systemic B lymphoma was confirmed. A treatment based on intravitreal methotrexate was carried out, achieving the regression of the vitreous infiltration and resolution of the optic disc edema. Systemic B lymphoma metastasizing ocular structures is extremely infrequent. The manifestations may mimic an inflammatory disease. Ophthalmologists should be aware of these manifestations and consider among the masquerade syndromes.
ABSTRACT
PURPOSE: To report a case of macular edema and an epiretinal membrane in an isolated astrocytic hamartoma treated surgically. METHODS: Case report. RESULTS: We describe the case of a 37-year-old woman whose first symptoms were blurred vision and metamorphopsia. Optical coherence tomography revealed macular edema together with an epiretinal membrane secondary to an isolated retinal astrocytic hamartoma. We performed a pars plana vitrectomy (PPV) with membrane peeling. Both visual and structural outcomes were satisfactory. Complete resolution of symptoms was obtained, and visual acuity was preserved after a 7-month follow-up. CONCLUSION: Although rare, epiretinal membrane may be present in isolated retinal astrocytic hamartomas, PPV and epiretinal membrane peeling may be a good treatment option in glial tumors with macular edema associated with an epiretinal membrane.
ABSTRACT
Ocular toxoplasmosis causes abnormalities in the vitreous that are responsible for several types of well-known complications including retinal detachment and epiretinal membranes. We report on a patient who developed toxoplasmic panuveitis with a full-thickness macular hole (MH) and was successfully treated with vitreoretinal surgery. A 35-year-old Hispanic female presented with a 2-week history of loss of visual acuity and metamorphopsia in her right eye. Funduscopy revealed a typical toxoplasmosis lesion and a MH, which was confirmed by optical coherence tomography. After 8 weeks of medical treatment with sulfamethoxazole (800 mg)/trimethoprim (160 mg) and steroids, the intraocular inflammation was considered inactive. Pars plana vitrectomy with inner limiting membrane peeling and injection of 24 % sulphur hexafluoride gas were performed to treat the MH, without success. Repeat pars plana vitrectomy was then performed with injection of 14 % perfluoropropane (C3F8). Closure of the MH was achieved after this second procedure. Vitreoretinal surgery may be safe and effective for treating MHs secondary to toxoplasmosis lesions, a very uncommon complication of this disease.
Subject(s)
Chorioretinitis/parasitology , Retinal Perforations/etiology , Toxoplasmosis, Ocular/complications , Adult , Female , Humans , Treatment Outcome , Vitrectomy/methodsABSTRACT
PURPOSE: To describe a case of sarcoid uveitis subsequent to anti-TNFα therapy and review previously reported cases. METHODS: Review of the clinical records of the authors' patient and of the literature using the PubMed database. RESULTS: A 30-year-old woman presented with intermediate uveitis with snowballs in both eyes. She was on treatment with etanercept due to psoriatic arthritis. An ultrasound-guided biopsy of a mediastinal adenopathy showed non-necrotizing granulomas compatible with sarcoidosis. The clinical picture resolved after etanercept was withdrawn and treatment with immunosuppressants. In a literature search the authors identified six other cases of sarcoid uveitis induced by anti-TNFα therapy. The types of uveitis were anterior uveitis, posterior uveitis, or panuveitis. Management consisted of withdrawal of anti-TNFα therapy and administration of immunosuppressive agents in 5 cases. CONCLUSIONS: Sarcoid uveitis induced by TNFα antagonists is a rare complication. Appropriate management consists of withdrawing the TNFα antagonist and giving immunosuppressants.
Subject(s)
Immunoglobulin G/adverse effects , Sarcoidosis/chemically induced , Uveitis, Intermediate/chemically induced , Adult , Arthritis, Psoriatic/drug therapy , Diagnosis, Differential , Etanercept , Female , Follow-Up Studies , Humans , Immunoglobulin G/therapeutic use , Immunosuppressive Agents/adverse effects , Immunosuppressive Agents/therapeutic use , Microscopy, Acoustic , Receptors, Tumor Necrosis Factor/therapeutic use , Sarcoidosis/diagnosis , Tumor Necrosis Factor-alpha/antagonists & inhibitors , Uveitis, Intermediate/diagnosisSubject(s)
Exfoliation Syndrome/etiology , Amino Acid Oxidoreductases/deficiency , Amino Acid Oxidoreductases/genetics , Elastic Tissue/metabolism , Exfoliation Syndrome/drug therapy , Exfoliation Syndrome/genetics , Exfoliation Syndrome/metabolism , Folic Acid Deficiency/complications , Folic Acid Deficiency/diagnosis , Folic Acid Deficiency/drug therapy , Humans , Hyperhomocysteinemia/complications , Hyperhomocysteinemia/diagnosis , Hyperhomocysteinemia/drug therapy , Myocardial Ischemia/epidemiology , Myocardial Ischemia/etiology , Oxidative Stress , Polymorphism, Single Nucleotide , Risk Factors , Vitamin B 12 Deficiency/complications , Vitamin B 12 Deficiency/diagnosis , Vitamin B 12 Deficiency/drug therapy , Vitamin B 6 Deficiency/complications , Vitamin B 6 Deficiency/diagnosis , Vitamin B 6 Deficiency/drug therapyABSTRACT
No disponible
Subject(s)
Humans , Intraocular Pressure/physiology , Cataract/epidemiology , Exfoliation Syndrome/epidemiology , Intraocular Pressure , Intraocular Pressure/immunologyABSTRACT
PURPOSE: To report a case of neuroretinitis associated with ischemic nasal branch retinal vein occlusion, periphlebitis, and neovascularization of the optic disk. METHODS: Case report. RESULTS: A 32-year-old man presented with a typical image of neuroretinitis, retinal hemorrhages and sheathing of the retinal veins in the nasal retina. His left hand had been bitten by a kitten 8 weeks before. Serology for Bartonella henselae was negative. On the 6th week of follow-up, optic disk neovascularization developed, which required retinal photocoagulation. Photocoagulation was performed again at the 12th and 18th week revision since further new vessels had developed. At the 32nd week of follow-up neovascularization had regressed. CONCLUSIONS: Neuroretinitis may be associated with severe complications such as retinal vascular occlusions and optic disk neovascularization.
