[Reinterpretation of the Malpighian body in light of the existence of a single glomerular arteriole (Trabucco and Marquez)]. / Reinterpretación de la estructura del corpúsculo de Malpighi en función de la existencia de una sola arteriola glomerular (Trabucco y Márquez).

INTRODUCTION: In 1842 William Bowman described the microvascular system of the Malpighian body. Electron microscopic studies definitively revealed the spatial structure of its mesangial-capillary-epithelial component. In 1952-54 Trabucco and Marquez challenged the ideas of Bowman, demonstrating the existence of a single glomerular arteriole. Our study supports the finding of a single glomerular arteriole, leading to a definitive interpretation of the Malpighian body structure. MATERIALS AND METHODS: Serial histological studies were carried out of the vascular pole in a case of oligomeganephrotic renal hypoplasia and the immunohistochemical study of embryonal glomerular development (15 embryos aged between 7 and 11weeks), with alpha-actin (smooth muscle marker), CD31 and CD34 (endothelial markers) and CD10 (podocyte marker). RESULTS: The study of the glomerular vascular pole in the case of oligomeganephrotic renal hypoplasia supports the existence of a single glomerular arteriole. Our immunohistochemical study confirmed this finding and provided data on the morphogenesis of the mesangial-capillary-epithelial component of the Malpighian body. CONCLUSIONS: There exist a single glomerular arteriole. Mesangial and endothelial cells originating from a single glomerular arteriole interact with an epithelial component derived from the nephrogenic vesicle which then generate the lobular glomerular tuft, providing the basis for a definitive interpretation of the structure of the Malpighian body. There is no scientific base to the interpretation of the glomerular microvascular system as having two glomerular arterioles with an intercalated capillary network.

Colecistitis aguda alitiásica como manifestación inicial de una granulomatosis eosinofílica con poliangeítis (Churg-Strauss). A propósito de un caso / Acute acalculous cholecystitis as the initial manifestation of eosinophilic granulomatosis with polyangiitis (Churg-Strauss). A case report

La granulomatosis eosinofílica con poliangeítis (Churg-Strauss) es una vasculitis sistémica con inflamación granulomatosa necrosante, rica en eosinófilos, a menudo con afectación del tracto respiratorio y vasculitis necrosante que afecta vasos pequeños y medianos, asociado con asma y eosinofilia. Presentamos un paciente cuya manifestación inicial de la enfermedad fue una colecistitis aguda alitiásica por vasculitis. Aunque la colecistitis aguda alitiásica como síntoma inicial de la granulomatosis eosinofílica con poliangeítis es muy infrecuente, se debería tener en cuenta en el diagnóstico en pacientes con dolor abdominal de origen desconocido con eosinofilia, asma o rinitis alérgica (AU)

Eosinophilic granulomatosis with polyangiitis (Churg-Stauss) is a systemic vasculitis with eosinophil-rich and necrotizing granulomatous inflammation and necrotizing vasculitis predominantly affecting small to medium vessels. It often involves the respiratory tract and is associated with asthma and eosinophilia. We describe a case in which acute acalculous cholecystitis was the initial manifestation of the disease. Although acute acalculous cholecystitis rarely appears as an early manifestation in eosinophilic granulomatosis with polyangiitis, this entity should be taken into consideration in the differential diagnosis of patients with abdominal pain of unknown origin and a history of eosinophilia, asthma, or allergic rhinitis (AU)