[Effect of naproxen on serum concentrations of IL-I, IL-6, and TNF in patients with osteoarthritis]. / Efecto del naproxeno en las concentraciones séricas de IL-I, IL-6 y TNF en pacientes con osteoartritis.

AIMS: Non-steroid anti-inflammatory drugs can inhibit bone loss and preserve bone mineral density in in vitro models by inhibiting prostaglandins and inflammatory cytokines. Naproxen inhibits prostaglandin and cytokine biosynthesis. Our objective was to assess the effect of naproxen on the serum levels of IL-I, IL-6 and TNF in 18 patients with osteoarthritis. MATERIAL AND METHOD: Two groups of nine patients each were formed randomly. One of them received naproxen 10 mg/kg BW bid for 2 weeks, and the other received placebo and paracetamol as needed. Cytokines were measured before and 2 weeks after naproxen administration by ELISA test. RESULTS: Serum IL-I and IL-6 levels were reduced in the group receiving naproxen, suggesting a reduction of the degenerative changes in the patients with osteoarthritis, that may prevent the progression of the disease.

[Effect of naproxen sodium on serum concentrations of IL-1, IL-6, and TNF in patients with acute, purulent pharyngo-tonsillitis]. / Efecto del naproxeno sódico en las concentraciones séricas de IL-1, IL-6 y TFN en pacientes con faringoamigdalitis aguda purulenta.

BACKGROUND: Cytokines produced by macrophages and neutrophils participate in the host's defense mechanism; in infectious processes. Interleukins such as LI-1, IL-6, and tumor necrosis factor (TNF) also have a role in these acute phase mechanisms. OBJECTIVE: Assess the effect of sodium naproxen on the serum concentration of IL-1, IL-6 and TNF in acute infectious process. MATERIAL A METHODS: Eighteen patients with clinical diagnosis of acute purulent pharyngitis and/or tonsillitis were randomly assigned to one of two groups of 9 patients each. RESULTS: The patients in the first group received sodium naproxen and those in the other group received placebo. Patients of both groups received procaine G penicillin. Patients in the group receiving sodium naproxen showed improvement of the infectious and febrile syndromes within 72 hours. Patients receiving placebo showed signs and symptoms; of the infections and febrile syndromes for more than three days. DISCUSSION: Patients receiving treatment with sodium naproxen had a statistically significant reduction of the serum concentration of IL-1b as compared to basal and 72 h measurements; there were also statistically significant differences with respect to patients receiving placebo. IL-6 and TNF did not change in any of the groups. These results show that serum IL-1b levels dropped in both groups with a more striking reduction in the group receiving sodium naproxen , that also showed a faster improvement of the symptoms.

Single blind study to evaluate the efficacy and safety of naproxen gel compared with diclophenac emulgel in the treatment of soft tissue injuries.

Sixty four adult patients of both genders with injuries such as contusions and sprains were studied. Of these, 34 were treated with 10% naproxen gel and 30 with 1% dichlophenaco gel topically given for 4 days. Various pain modalities, edema and functional alterations of areas involved were studied. Naproxen reduced spontaneous pain slightly better than dichlophenaco. Both drugs resulted in significant reduction of other pain modalities, edema and functional alterations (p < 0.001). A lower percentage (29%) of naproxen patients used paracetamol as additional pain reliever compared to dichlophenaco patients (36%). Local adverse events were minimum for both groups.

[Physiology of the ovary. VI. Anovulatory menstruation]. / Fisiología óvarica. VI. Menstruación anovulatoria

In 65 patients with menstrual cycle alterations--in it's length and/or amount of bleeding--estradiol-progesterone relationship was studied. The plasma levels of these hormones were correlated with basal temperature, length of menstrual cycle and histologic study of endometrium. The patient- were grouped as follows: I excessive menstrual bleeding; II short menstrual cycles; III long menstrual cycles; IV increment of bleeding period and, V uterine hemorrhage. All patients had an anovulatory menstrual cycle; peripheral concentration of progeseterone was less than 6 ng/ml and mean concentration of estradiol was not statistically higher than that found in normal patients (83+/-23 pg/ml). Based upon these findings, it is postulated that the term of hyperestrogenism or excessive estrogen production should not be used when referring to these menstrual cycle alterations.