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3.
Eur J Vasc Endovasc Surg ; 41(4): 548-53, 2011 Apr.
Article in English | MEDLINE | ID: mdl-21277234

ABSTRACT

OBJECTIVES: Pelvic arteriovenous malformations (AVMs) are difficult to treat. Arterial embolisation is the most common strategy but often has poor results. We report an alternative surgical approach of controlled intra-operative transvenous embolisation with long-term results in seven cases. MATERIALS AND METHODS: Between 1980 and 2008, we treated seven patients (four men, three women, mean age 50 years). Indications were rectal bleeding (one case), urinary tract problems (four cases), oedema of lower limb (one case) and high-output cardiac failure (one case). Four of them had previous operations and three had previous attempts for embolisation. Embolisation of the malformation was performed through the internal iliac vein. This was done after clamping of all the feeding and draining vessels. The agent used was cyanocrylate (one case), Ethibloc (one case) and bone wax (five cases). RESULTS: Mortality was 0%. Complications occurred in two patients (28,5%), one pulmonary embolism and one regressive femoral paresis. Three patients were re-operated for various reasons. The mean follow-up period was 6 years (1-12 years). Symptoms resolved in all patients, while control by computed tomography (CT) angioscan revealed one residual shunt. CONCLUSION: Complete surgical excision of pelvic AVMs is not always possible. Embolisation does not offer a permanent cure. Intra-operative transvenous embolisation of persisting complex AVMs appears to be an alternative approach with good immediate and long-term results. Ethylene glycol appears to be the most suitable agent.


Subject(s)
Arteriovenous Malformations/therapy , Embolization, Therapeutic , Pelvis/blood supply , Vascular Surgical Procedures , Adult , Arteriovenous Malformations/diagnostic imaging , Arteriovenous Malformations/surgery , Combined Modality Therapy , Cyanoacrylates/administration & dosage , Diatrizoate/administration & dosage , Drug Combinations , Embolization, Therapeutic/adverse effects , Embolization, Therapeutic/methods , Fatty Acids/administration & dosage , Female , Humans , Male , Middle Aged , Palmitates/administration & dosage , Paris , Propylene Glycols/administration & dosage , Reoperation , Retrospective Studies , Time Factors , Tomography, X-Ray Computed , Treatment Outcome , Waxes , Zein/administration & dosage
4.
Br J Radiol ; 82(984): e243-5, 2009 Dec.
Article in English | MEDLINE | ID: mdl-19934064

ABSTRACT

We report a case of a mucinous cystadenoma of the pancreas communicating with the main pancreatic duct. To our knowledge, this is the first case in which a communication between the mucinous cystadenoma and the main pancreatic duct could be demonstrated by MRI.


Subject(s)
Cystadenoma, Mucinous/diagnosis , Pancreatic Ducts , Pancreatic Neoplasms/diagnosis , Adenocarcinoma, Mucinous/diagnosis , Carcinoma, Papillary/diagnosis , Cholangiopancreatography, Magnetic Resonance , Cystadenoma, Mucinous/pathology , Diagnosis, Differential , Female , Humans , Middle Aged , Pancreatic Neoplasms/pathology
5.
AJR Am J Roentgenol ; 175(6): 1619-25, 2000 Dec.
Article in English | MEDLINE | ID: mdl-11090390

ABSTRACT

OBJECTIVE: The objective of our study was to evaluate the efficacy and safety of radiofrequency ablation of hepatic metastases performed either percutaneously for treatment of hepatic metastases in patients deemed ineligible for surgery or intraoperatively during partial hepatectomy to destroy unresectable metastases. SUBJECTS AND METHODS: Sixty-eight patients with 121 hepatic metastases (<5 metastases per patient) that were mainly colorectal in origin underwent 76 sessions of radiofrequency ablation with cooled-needle electrodes under sonographic guidance. Twenty-one patients with 33 metastases of 5-20 mm in diameter (mean +/- SD,13 +/- 7 mm) underwent intraoperative radiofrequency ablation. Forty-seven patients with 88 metastases of 10 to 42 mm in diameter (mean +/- SD, 26 +/- 9 mm) were treated with percutaneous radiofrequency ablation. Procedure efficacy was evaluated with dynamic enhanced CT and MR imaging performed 2, 4, and 6 months after treatment and then every 3 months. RESULTS: Radiofrequency ablation allowed eradication of 91% of the 100 treated metastases that were followed up for 4-23 months (mean, 13.7 months). Tumor control was equivalent for percutaneous radiofrequency ablation (90%) and for intraoperative radiofrequency ablation (94%). Failure to achieve tumor control occurred mostly with the largest tumor nodules. One bilioperitoneum and two abscesses were the major complications encountered after treatment of 121 metastases with a follow-up of more than 2 months. CONCLUSION: Radiofrequency ablation appears to be a promising therapeutic modality capable of extending the possibilities of partial hepatectomy and of efficiently treating small metastases percutaneously.


Subject(s)
Catheter Ablation , Liver Neoplasms/secondary , Liver Neoplasms/surgery , Adult , Aged , Colorectal Neoplasms/pathology , Female , Follow-Up Studies , Hepatectomy , Humans , Male , Middle Aged , Time Factors , Treatment Outcome , Ultrasonography, Interventional
6.
Biochem Biophys Res Commun ; 275(2): 322-7, 2000 Aug 28.
Article in English | MEDLINE | ID: mdl-10964665

ABSTRACT

A new cell line was derived from primary culture of rat choroid plexus (RCP) by immortalization with the TSOri minus adenovirus. The selected clone expressed vasopressin V1a receptors at a density of 64,000 sites per cell, and a K(d) of 7.2 nM. Addition of vasopressin to the RCP cells induced a transient calcium peak comparable to V1a receptor signalling in different expression systems. This [Ca(2+)](i) increase was dose-dependent with an EC(50) of 22 nM vasopressin. Similar [Ca(2+)](i) increase was elicited by addition of serotonin, angiotensin II, endothelin-1, and bradykinin. Heterologous desensitization of V1a receptor was observed in RCP cells exposed to the phorbol ester PMA or following stimulation of other receptors coupled to the phosphoinositide pathway. Positive immunolabelling with Factor VIII, Flt1 and CD 34 antibodies suggests that this new RCP cell line originated from endothelial cells of rat choroid plexus.


Subject(s)
Choroid Plexus/metabolism , Receptors, Vasopressin/metabolism , Signal Transduction , Animals , Calcium Signaling , Cell Line , Choroid Plexus/cytology , Immunohistochemistry , Protein Binding , Rats , Rats, Wistar
7.
Gastrointest Endosc ; 40(3): 290-5, 1994.
Article in English | MEDLINE | ID: mdl-8056230

ABSTRACT

From June 1991 to September 1992, 16 patients (mean age, 72 +/- 5 years) were treated with intra-corporeal laser lithotripsy (ICL). Thirteen patients had choledocholithiasis with at least one stone larger than 20 mm; 3 patients had intra-hepatic lithiasis. All other methods, including mechanical lithotripsy, extra-corporeal lithotripsy (1 case), and intra-corporeal electrohydraulic lithotripsy (1 case), had failed to clear the bile ducts. Approaches for ICL were choledochoscopy with a "baby" endoscope via an existing sphincterotomy (8 cases), retrograde cholangioscopy with a gastroscope through a choledochoduodenal anastomosis or a sphincterotomy in patients with a gastrojejunal anastomosis (5 cases), and trans-hepatic cholangioscopy with a fibercholangioscope (3 cases, in 1 of which retrograde and trans-hepatic approaches were combined). Free bile ducts were obtained in 14/16 (87.5%) patients after a mean of 1.66 ICL sessions per patient. Mortality and laser-related morbidity did not occur; endoscopy-related morbidity was 12.5% for minor complications (1 transitory fever, 1 mild and transitory hemobilia) and 6.25% for major complications (1 post-sphincterotomy hemorrhage). Mean length of hospital stay was 11.5 +/- 2.5 days. We conclude that although it is rarely indicated and is expensive, ICL does offer a limited treatment option in selected patients. It allows the complete relief of complex biliary lithiasis. Morbidity is related to maneuvers preceding ICL, not to ICL itself.


Subject(s)
Bile Ducts, Intrahepatic/pathology , Cholelithiasis/therapy , Gallstones/therapy , Lithotripsy, Laser , Adult , Aged , Aged, 80 and over , Bile Duct Diseases/therapy , Cholangiopancreatography, Endoscopic Retrograde , Choledochostomy , Endoscopy, Digestive System/adverse effects , Endoscopy, Digestive System/instrumentation , Endoscopy, Digestive System/methods , Female , Follow-Up Studies , Hemobilia/etiology , Humans , Lithotripsy, Laser/adverse effects , Lithotripsy, Laser/methods , Male , Middle Aged , Sphincterotomy, Endoscopic/adverse effects , Sphincterotomy, Endoscopic/instrumentation , Sphincterotomy, Endoscopic/methods , Time Factors , Treatment Outcome
9.
Gastroenterol Clin Biol ; 17(10): 629-35, 1993.
Article in French | MEDLINE | ID: mdl-7507069

ABSTRACT

Between March 1982 and December 1987, 466 patients (256 women, 210 men, mean age 73 years) with tumor obstruction of the common bile duct were referred to our department. The causes of obstruction were carcinoma of the pancreas (298 patients), carcinoma of the ampulla of Vater (32 patients) and carcinoma of the common bile duct (136 patients). Endoscopical insertion of a biliary prosthesis was initially possible in 377 patients (81%). In case of failure, patients were referred to the radiologist for percutaneous drainage. Successful drainage was obtained in 58 patients with an overall success rate of 93% (435 patients). Endoscopic replacement was necessary in 170 cases for 114 patients and was successful in 155 (91%). Pruritus was relieved in 89% of the patients. Serum bilirubin levels decreased more than 75% after initial endoscopic endoprosthesis, repeated endoscopic endoprosthesis and percutaneous prosthesis insertion in 80%, 79%, and 62% of the patients, respectively. Short term complications of endoscopic endoprosthesis occurred in 28% of patients with a mortality rate of 8%. Percutaneous prosthesis complications occurred in 33% of patients with a mortality rate of 11%. In the long term, cholangitis was the main complication and occurred in 27% of patients with a delay of 103 +/- 105 days. Intestinal obstruction was observed in 7% of patients. The average life expectancy of endoscopic endoprosthesis and percutaneous prosthesis was 109 +/- 157 and 92 +/- 101 days, respectively. The average life expectancy of patients was 163 +/- 224 days.(ABSTRACT TRUNCATED AT 250 WORDS)


Subject(s)
Cholestasis, Extrahepatic/therapy , Common Bile Duct Neoplasms/complications , Intubation/methods , Pancreatic Neoplasms/complications , Stents , Adult , Aged , Aged, 80 and over , Cholangitis/etiology , Cholangitis/mortality , Cholestasis, Extrahepatic/etiology , Cholestasis, Extrahepatic/mortality , Common Bile Duct Neoplasms/pathology , Endoscopy, Digestive System/methods , Female , Humans , Intubation/adverse effects , Male , Middle Aged , Neoplasm Invasiveness , Palliative Care , Pancreatic Neoplasms/pathology , Postoperative Complications
11.
Presse Med ; 21(17): 796-9, 1992.
Article in French | MEDLINE | ID: mdl-1351676

ABSTRACT

The long-term prognosis of Takayasu's disease depends on an elective surgical treatment which requires full and accurate assessment of the lesions. We present here a retrospective study of 50 patients explored before surgery by intra-arterial digital angiography. In 92 percent of the patients the thoraco-abdominal aorta and its branches were well documented on 2 orthogonal projections performed in one single session. The high-quality intra-arterial opacification made it possible to detect incipient parietal lesions and to evaluate the lesions of the small caliber branches and the downstream bed in case of occlusion. These advantages, and the absence of morbidity in our experience, make digital panarteriography a method of choice to evaluate Takayasu's disease.


Subject(s)
Angiography, Digital Subtraction/methods , Takayasu Arteritis/diagnostic imaging , Adolescent , Adult , Aged , Angiography , Aorta, Abdominal/diagnostic imaging , Aorta, Thoracic/diagnostic imaging , Contrast Media , Female , Femoral Artery , Humans , Male , Middle Aged , Preoperative Care , Retrospective Studies
12.
Tucumán; Estación Experimental Agrícola; 1956. 12 p. tab.
Monography in Spanish | BINACIS | ID: biblio-1218921

ABSTRACT

Describe experiencias a escala laboratorio sobre obtención de cera vegetal a partir de la cachaza, (residuo producido en el proceso industrial de obtención de azúcar de caña). Se ensayó la extracción con 8 distintos solventes, concluyéndose que la nafta común (gasolina) es el mas conveniente, por costo y rendimiento. Para la purificación de la cera bruta obtenida se ensayó la extracción con acetona, en seis etapas. Las experiencias indicaron que es posible obtener cera de buena calidad, con un rendimiento del 64 por ciento con respecto al peso seco de cachaza, y sin afectar las propiedades totalizantes de esta última


Subject(s)
Argentina , Sugar Industry , Industrial Waste , Solid Waste Use
13.
Tucumán; Estación Experimental Agrícola; 1956. 12 p. Tablas.
Monography in Spanish | BINACIS | ID: bin-134820

ABSTRACT

Describe experiencias a escala laboratorio sobre obtención de cera vegetal a partir de la cachaza, (residuo producido en el proceso industrial de obtención de azúcar de caña). Se ensayó la extracción con 8 distintos solventes, concluyéndose que la nafta común (gasolina) es el mas conveniente, por costo y rendimiento. Para la purificación de la cera bruta obtenida se ensayó la extracción con acetona, en seis etapas. Las experiencias indicaron que es posible obtener cera de buena calidad, con un rendimiento del 64 por ciento con respecto al peso seco de cachaza, y sin afectar las propiedades totalizantes de esta última


Subject(s)
Argentina , Industrial Waste , Solid Waste Use , Sugar Industry
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