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Virus Res ; 144(1-2): 225-32, 2009 Sep.
Article in English | MEDLINE | ID: mdl-19447147

ABSTRACT

Glycans terminating in sialic acids serve as receptors for influenza viruses. In this study ferrets were infected with influenza virus A/New Caledonia/20/99, and the in situ localization of sialic acids linked alpha2-3 and alpha2-6 in the airways was investigated in infected and non-infected animals by use of sialic acid detecting lectins and a monoclonal antibody towards the Sialyl-Tn antigen. The goblet cells in the bronchi from non-infected ferrets expressed Sialyl alpha 2-6Gal glycans, while the seromucinous glands in the submucosa expressed Sialyl alpha 2-3Gal glycans. In the infected animals, the surface epithelial cells in some bronchi showed metaplasia and expressed the Sialyl-Tn antigen: Sialyl alpha 2-6GalNAc-O-Thr/Ser. The submucosal tracheal glands in these animals showed increased expression of both Sialyl alpha 2-3 and Sialyl alpha 2-6 epitopes.


Subject(s)
Influenza A Virus, H1N1 Subtype/growth & development , Respiratory Mucosa/chemistry , Sialic Acids/biosynthesis , Animals , Antibodies, Monoclonal/metabolism , Female , Ferrets , Lectins/metabolism , Metaplasia/pathology , Respiratory Mucosa/pathology
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