DeepSplice: a deep learning approach for accurate prediction of alternative splicing events in the human genome.

Alternative splicing (AS) is a crucial process in genetic information processing that generates multiple mRNA molecules from a single gene, producing diverse proteins. Accurate prediction of AS events is essential for understanding various physiological aspects, including disease progression and prognosis. Machine learning (ML) techniques have been widely employed in bioinformatics to address this challenge. However, existing models have limitations in capturing AS events in the presence of mutations and achieving high prediction performance. To overcome these limitations, this research presents deep splicing code (DSC), a deep learning (DL)-based model for AS prediction. The proposed model aims to improve predictive ability by investigating state-of-the-art techniques in AS and developing a DL model specifically designed to predict AS events accurately. The performance of the DSC model is evaluated against existing techniques, revealing its potential to enhance the understanding and predictive power of DL algorithms in AS. It outperforms other models by achieving an average AUC score of 92%. The significance of this research lies in its contribution to identifying functional implications and potential therapeutic targets associated with AS, with applications in genomics, bioinformatics, and biomedical research. The findings of this study have the potential to advance the field and pave the way for more precise and reliable predictions of AS events, ultimately leading to a deeper understanding of genetic information processing and its impact on human physiology and disease.

Detection of COVID-19 using edge devices by a light-weight convolutional neural network from chest X-ray images.

Deep learning is a highly significant technology in clinical treatment and diagnostics nowadays. Convolutional Neural Network (CNN) is a new idea in deep learning that is being used in the area of computer vision. The COVID-19 detection is the subject of our medical study. Researchers attempted to increase the detection accuracy but at the cost of high model complexity. In this paper, we desire to achieve better accuracy with little training space and time so that this model easily deployed in edge devices. In this paper, a new CNN design is proposed that has three stages: pre-processing, which removes the black padding on the side initially; convolution, which employs filter banks; and feature extraction, which makes use of deep convolutional layers with skip connections. In order to train the model, chest X-ray images are partitioned into three sets: learning(0.7), validation(0.1), and testing(0.2). The models are then evaluated using the test and training data. The LMNet, CoroNet, CVDNet, and Deep GRU-CNN models are the other four models used in the same experiment. The propose model achieved 99.47% & 98.91% accuracy on training and testing respectively. Additionally, it achieved 97.54%, 98.19%, 99.49%, and 97.86% scores for precision, recall, specificity, and f1-score respectively. The proposed model obtained nearly equivalent accuracy and other similar metrics when compared with other models but greatly reduced the model complexity. Moreover, it is found that proposed model is less prone to over fitting as compared to other models.