Impact of Group vs Individual Embryo Culture Strategies on Blastocyst and Clinical Outcomes.

Embryo culture is one of the most important steps in an assisted reproduction laboratory. Embryos can be cultured individually, one embryo per media drop, or in groups, culturing several embryos in the same media drop. Due to the controversy generated on this subject, we wondered which embryo culture method would have the best results in terms of quality and blastocyst formation rate. We designed a prospective randomized study comparing two different embryo culture strategies: group and individual embryo culture. The data were obtained from 830 embryos from 103 egg donation treatments. The zygotes were randomized into two groups: individual culture (group 1) or group culture (group 2). The embryos were cultured in 35-µl drops until day 5 when they were classified morphologically. We observed a significant increase in the blastocyst formation rate and in the usable embryo rate in individual culture on day 5 compared to group culture. However, good embryo quality (A/B blastocysts), implantation, and pregnancy rates were similar regardless of the type of embryo-culture. As a conclusion, individual culture may increase blastocyst formation rate and may benefit embryo quality on day 5. Our results support previous reports suggesting that individual culture could improve embryo development.

Characteristics and clinical challenges in patients with substance use disorder in palliative care-experience from a tertiary center in a high-income country.

BACKGROUND: Access to palliative care is often limited for challenging and vulnerable groups, including persons with substance use disorders. However, with optimized healthcare options and liberal substitution policies, this patient group is likely to increase over the upcoming years, and comorbidities will also influence the need for palliative support. Here, we aim at analyzing characteristics and specific challenges associated with substance use disorders (SUD) in palliative care. METHODS: We retrospectively reviewed all patients diagnosed with substance use disorder that were treated at our Competence Center Palliative Care within the University Hospital Zurich, Switzerland between 2015 and 2021. Patient characteristics, including age, gender, duration of hospitalization, as well as specific metrics like body mass index, distinct palliative care assessment scores, and in-hospital opioid consumption were retrieved from the electronic patient files. Demographics and clinical data were analyzed by descriptive statistics, and compared to those of a control group of palliative care patients without SUD. An opioid calculator was used to standardize opioid intake based on morphine equivalents for meaningful comparisons. RESULTS: The primary characteristics revealed that the majority of individuals were single (56%), had no children (83%), lived alone (39%), and were either unemployed or recipients of a disability pension (in total 50%). Nicotine (89%), opioids (67%), and alcohol (67%) were the most used substances. We identified various comorbidities including psychiatric illnesses alongside SUD (56%), hepatitis A, B, or C (33%), and HIV infection (17%). Patients with SUD were significantly younger (p < 0.5), predominantly male (p < 0.05), and reported a higher prevalence of pain (p < 0.5) compared to the standard cohort of palliative patients. Regarding the challenges most frequently reported by healthcare practitioners, non-compliance, multimorbidity, challenging communication, biographical trauma, lack of social support, and unstable housing situations played a key role. CONCLUSION: Patients with SUD represent a complex and vulnerable group dealing with multiple comorbidities that profoundly affect both their physical and psychological well-being. Understanding their unique characteristics is pivotal in providing precise and suitable palliative care.

Historia de la anticoncepción y planificación familiar: una revisión narrativa / História da contracepção e do planeamento familiar: revisão narrativa / History of contraception and family planning: a narrative review

Introduction: Contraception has played a central role in much of human history. Since the separation of reproduction from sexuality, in addition to preventing sexually transmitted diseases, contraceptive methods have been used as a tool for birth control, varying in their presentation throughout history, influenced by socio-economic and cultural processes. Method: A narrative review was conducted in the biomedical databases: Scielo, Pubmed, Dialnet, CUIDEN and Google Scholar. The literature search was conducted between August and December 2021. Results: Initial search strategies identified a total of 48247 articles. Once exclusion criteria were applied, 19 journal articles (6 in Scielo, 3 in Pubmed, 2 in Dialnet, 2 in CUIDEN, and 6 in Google Scholar) and 2 books were selected. Conclusions: The resources and culture of society have conditioned sexuality and reproduction in each historical moment. In the 20th century, the struggle for women's rights and freedom over birth control began, thus implementing family planning, which has since provided information about contraceptive methods and facilitated free and confidential access to them.(AU)

Introducción: La anticoncepción ha sido protagonista de gran parte de la historia del ser humano. Desde que se separó la reproducción de la sexualidad, además de para prevenir enfermedades de transmisión sexual, los métodos anticonceptivos han sido utilizados como herramienta de control de natalidad, variando su presentación a lo largo de la historia, influenciada por procesos socioeconómicos y culturales. Método: Se realizó una revisión narrativa en las bases de datos biomédicas: Scielo, Pubmed, Dialnet, CUIDEN y Google Scholar. La búsqueda bibliográfica se realizó entre los meses de Agosto y Diciembre de 2021. Resultados: Las estrategias de búsqueda iniciales identificaron un total de 48247 artículos. Una vez aplicados los criterios de exclusión, se seleccionaron 19 artículos de revista (6 en Scielo, 3 en Pubmed, 2 en Dialnet, 2 en CUIDEN y 6 en Google Scholar) y 2 libros. Conclusiones: Los recursos y la cultura de la sociedad han sido condicionantes de la sexualidad y la reproducción en cada momento histórico. En el s.XX se inició la lucha por el derecho y libertad de la mujer sobre el control de la natalidad, implementándose así la planificación familiar, que, desde entonces, proporciona información sobre los métodos anticonceptivos y facilita su acceso de forma libre y confidencial.(AU)

Introdução: A contracepção tem desempenhado um papel central em grande parte da história humana. Desde a separação da reprodução da sexualidade, para além da prevenção de doenças sexualmente transmissíveis, têm sido utilizados métodos contraceptivos como instrumento de controlo da natalidade, variando na sua apresentação ao longo da história, influenciados por processos socioeconómicos e culturais. Método: Foi realizada uma revisão narrativa nas bases de dados biomédicas: Scielo, Pubmed, Dialnet, CUIDEN e Google Scholar. A pesquisa bibliográfica foi conduzida entre Agosto e Dezembro de 2021. Resultados: As estratégias iniciais de pesquisa identificaram um total de 48247 artigos. Uma vez aplicados os critérios de exclusão, foram seleccionados 19 artigos de revistas (6 no Scielo, 3 no Pubmed, 2 no Dialnet, 2 no CUIDEN e 6 no Google Scholar) e 2 livros. Conclusões: Os recursos e a cultura da sociedade têm condicionado a sexualidade e a reprodução em cada momento histórico. No século XX, começou a luta pelos direitos e liberdade das mulheres sobre o controlo da natalidade, implementando assim o planeamento familiar, que, desde então, fornece informações sobre métodos contraceptivos e facilita o acesso livre e confidencial aos mesmos.(AU)

Effects of an organic diet intervention on the levels of organophosphorus metabolites in an adult cohort.

Pesticides are a group of organic compounds used to control weeds or insect infestations in agriculture. Diet is the major route of human exposure to these compounds, which can cause serious health problems, even when the intake occurs at low concentrations. Hence, the consumption of organic food is an appropriate strategy to minimize the exposure to pesticides. A prospective, randomized study was conducted to assess the impact of an organic dietary intervention on the levels of urinary dialkyl phosphates (DAP). A screening of 204 pesticides was also carried out in order to confirm the absence of these compounds in organic food. The analytical results showed that only 20 of the 204 pesticides (9.8 %) had concentrations above the limit of quantification in one or more samples of the organic food consumed by the participants. It is substantially lower than the levels of pesticides found in other studies analysing conventional food, confirming the diet as suitable for the organic dietary intervention. A general reduction of most DAP metabolites in urine was found, being significant (p < 0.05) the decrease of dimethyl phosphate (DMP) (0.49 µg/g creatinine in Day 1 vs. 0.062 µg/g creatinine in Day 6), dimethyl thiophosphate (DMTP) (0.49 µg/g creatinine in Day 1 vs. 0.093 µg/g creatinine in Day 6) and diethyl phosphate (DEP) (0.28 µg/g creatinine in Day 1 vs. 0.12 µg/g creatinine in Day 6). In addition, the molar score for the total dimethyl DAP (ΣMP) and total dialkyl phosphate (ΣDAP) also showed significant differences after changing a conventional diet by an organic diet, being reduced from 0.008 µmol/g to 0.002 µmol/g for ΣMP and from 0.012 µmol/g to 0.003 µmol/g for ΣDAP. To the best of our knowledge, this is the first study that evaluates both the impact of an organic diet in the exposure to DAP and the levels of 204 pesticides in the organic food provided to the participants. In summary, the consumption of organic products decreases the dietary intake of pesticides, thus reducing also the potential adverse effects on human health.

Medication Adherence and Contraceptive Counseling.

Combined oral contraceptives (COC) are a very popular form of birth control. Incorrect use and lack of adherence to treatment reduce the effectiveness of this method. Having a standard tool to identify poor-adherence profiles quickly and objectively can be helpful for midwives and potentially for COC users. The MMAS-4 adherence scale has been used in various medical fields, but there is little evidence of its potential in contraceptive consultation. This paper presents a piece of multicenter observational research based on a sample of 327 women who had attended contraceptive counselling in Spain and were COC users or had informed the midwife that they want to start to use this method. Two interviews were conducted: at the time of consultation and after one year. In our research, the MMAS-4 identified high-risk behaviors: during the 1-year follow-up period, COC users classified as poorly adherent had a significantly higher risk of missed contraceptive pills, more incidents and problems related to the method of contraception, as well as a lower degree of satisfaction with the contraceptive method. One case of unplanned pregnancy and two cases of emergency contraception were identified, all of them corresponding to poorly adherent women. The use of MMAS-4 in consultation can improve midwives' contraceptive counselling.

Stability of Superhydrophobicity and Structure of PVDF Membranes Treated by Vacuum Oxygen Plasma and Organofluorosilanisation.

Superhydrophobic poly(vinylidene fluoride) (PVDF) membranes were obtained by a surface treatment consisting of oxygen plasma activation followed by functionalisation with a mixture of silica precursor (SiP) (tetraethyl-orthosilicate [TEOS] or 3-(triethoxysilyl)-propylamine [APTES]) and a fluoroalkylsilane (1H,1H,2H,2H-perfluorooctyltriethoxysilane), and were benchmarked with coated membranes without plasma activation. The modifications acted mainly on the surface, and the bulk properties remained stable. From a statistical design of experiments on surface hydrophobicity, the type of SiP was the most relevant factor, achieving the highest water contact angles (WCA) with the use of APTES, with a maximum WCA higher than 155° for membranes activated at a plasma power discharge of 15 W during 15 min, without membrane degradation. Morphological changes were observed on the membrane surfaces treated under these plasma conditions, showing a pillar-like structure with higher surface porosity. In long-term stability tests under moderate water flux conditions, the WCA of coated membranes which were not activated by oxygen plasma decreased to approximately 120° after the first 24 h (similar to the pristine membrane), whilst the WCA of plasma-treated membranes was maintained around 130° after 160 h. Thus, plasma pre-treatment led to membranes with a superhydrophobic performance and kept a higher hydrophobicity after long-term operations.

Cadmium exposure in adults across Europe: Results from the HBM4EU Aligned Studies survey 2014-2020.

The objectives of the study were to estimate the current exposure to cadmium (Cd) in Europe, potential differences between the countries and geographic regions, determinants of exposure and to derive European exposure levels. The basis for this work was provided by the European Human Biomonitoring Initiative (HBM4EU) which established a framework for alignment of national or regional HBM studies. For the purpose of Cd exposure assessment, studies from 9 European countries (Iceland, Denmark, Poland, Czech Republic, Croatia, Portugal, Germany, France, Luxembourg) were included and urine of 20-39 years old adults sampled in the years 2014-2021 (n = 2510). The measurements in urine were quality assured by the HBM4EU quality assurance/quality control scheme, study participants' questionnaire data were post-harmonized. Spatially resolved external data, namely Cd concentrations in soil, agricultural areas, phosphate fertilizer application, traffic density and point source Cd release were collected for the respective statistical territorial unit (NUTS). There were no distinct geographic patterns observed in Cd levels in urine, although the data revealed some differences between the specific study sites. The levels of exposure were otherwise similar between two time periods within the last decade (DEMOCOPHES - 2011-2012 vs. HBM4EU Aligned Studies, 2014-2020). The age-dependent alert values for Cd in urine were exceeded by 16% of the study participants. Exceedances in the different studies and locations ranged from 1.4% up to 42%. The studies with largest extent of exceedance were from France and Poland. Association analysis with individual food consumption data available from participants' questionnaires showed an important contribution of vegetarian diet to the overall exposure, with 35% higher levels in vegetarians as opposed to non-vegetarians. For comparison, increase in Cd levels due to smoking was 25%. Using NUTS2-level external data, positive associations between HBM data and percentage of cropland and consumption of Cd-containing mineral phosphate fertilizer were revealed, which indicates a significant contribution of mineral phosphate fertilizers to human Cd exposure through diet. In addition to diet, traffic and point source release were identified as significant sources of exposure in the study population. The findings of the study support the recommendation by EFSA to reduce Cd exposure as also the estimated mean dietary exposure of adults in the EU is close or slightly exceeding the tolerable weekly intake. It also indicates that regulations are not protecting the population sufficiently.

Valorization of Ferulic Acid from Agro-Industrial by-Products for Application in Agriculture.

The use of bioplastic mulch in agriculture has increased dramatically in the last years throughout the world. Nowadays, biodegradable materials for mulching films strive to constitute a reliable and more sustainable alternative to classical materials such as polyethylene (PE). The main challenge is to improve their durability in the soil to meet the required service length for crop farming by using benign and sustainable antioxidant systems. Here, we report the design and fabrication of biodegradable materials based on polybutylene (succinate adipate) (PBSA) for mulching applications, incorporating a fully biobased polymeric antioxidant deriving from ferulic acid, which can be extracted from an industrial by-product. Poly-dihydro (ethylene ferulate) (PHEF) from ferulic acid was synthesized by a two-step polymerization process. It is characterized by improved thermal stability in comparison with ferulic acid monomer and therefore suitable for common industrial processing conditions. Different blends of PBSA and PHEF obtained by melt mixing or by reactive extrusion were prepared and analyzed to understand the effect of the presence of PHEF. The results demonstrate that PHEF, when processed by reactive extrusion, presents a remarkable antioxidant effect, even in comparison with commercial additives, preserving a high level of the mechanical properties of the PBSA matrix without affecting the biodegradable character of the blend.

Contraceptive counselling experiences in Spain in the process of creating a web-based contraceptive decision support tool: a qualitative study.

BACKGROUND: The choice of contraceptive method is a complex decision, and professionals should offer counselling based on the preferences, values and personal situation of the user(s). Some users are unsatisfied with the counselling received, which may, among other consequences, adversely affect method use adherence. In view of this situation, we propose exploring the experiences and needs of users and professionals for contraceptive counselling, in the context of creating a web-based contraceptive decision support tool. METHODS/DESIGN: Qualitative research was conducted through focus group discussions (64 users split into eight groups, and 19 professionals in two groups, in Tarragona, Spain) to explore the subjects' experiences and needs. The data were categorized and the categories were defined and classified based on the three-step protocol or framework for Quality on Contraceptive Counseling (QCC), created by experts, which reviews the quality of interactions between user and professional during the counselling process. RESULTS: In counselling, users demand more information about the different methods, in an environment of erroneous knowledge and misinformation, which lead to false beliefs and myths in the population that are not contrasted by the professional in counselling. They complain that the method is imposed on them and that their views regarding the decision are not considered. Professionals are concerned that their lack of training leads to counselling directed towards the methods they know best. They acknowledge that a paternalistic paradigm persists in the healthcare they provide, and decision support tools may help to improve the situation. CONCLUSIONS: Users feel unsatisfied and/or demand more information and a warmer, more caring approach. Professionals are reluctant to assume a process of shared decision-making. The use of a contraception DST website may solve some shortcomings in counselling detected in our environment.

Development of Sciatic Neuropraxia following Abdominal Surgery in 3 Giant Breed Dogs.

This report describes the clinical course of three giant breed dogs (2 Great Danes and 1 Saint Bernard) that developed sciatic neuropraxia following successful surgical management of gastric dilatation and volvulus (GDV). All three patients received physical rehabilitation with varying degrees of success. Two patients died of unrelated causes within a year of their initial presentation. The third case recovered nerve function and is alive with minimal neurologic deficits at the time of publication. This paper is aimed at positing potential causes for this complication and highlighting the importance of proper management of giant-breed dogs during hospitalization. Special attention should be given in regards to intraoperative positioning and postoperative care including frequent walks or changes in positioning, deep kennel bedding, and physical therapy.

Does Ad Libitum Feeding during the Peri-Partum Improve the Sow Feed Intake and Performances?

This study hypothesized that the ad libitum feeding of sows during the peri-partum may increase the neonatal survival of the piglets and the post-partum recovery of the sow. The aim of the study was to evaluate the effects of two peri-partum feeding strategies (ad libitum and stepped from day 110 of gestation to day 5 post-partum) on the feed intake, the reproductive performance of sows, as well as the survival of their piglets. A total of 90 Landrace x Large-White dams sired by Duroc were used. The sows were randomly assigned to feeding treatments by balancing body condition and parity between groups. The feed intake of the sows in the peri-partum was lower in the stepped than in the ad libitum strategy. The increase of the feeding level in the ad libitum sows was not counterbalanced by higher number of weaned piglets or shorter weaned to oestrus interval.

Diseño y validación de una herramienta para medir la percepción de las condiciones de trabajo: caso Sector manufacturero de la región Caribe colombiana / Design and Validation of an Instrument to Measure the Perception of Working Conditions: Case ManufacturingSector Colombian Caribbean Region

El Cuestionario de Condiciones de Trabajo fue diseñado y aplicado como una herramienta de evaluación de la percepción de la seguridad en el trabajo en una muestra de 518 empleados de diferentes empresas del sector manufacturero de la región Caribe colombiana. Se realizaron análisis de confiabilidad, análisis factorial exploratorio y análisis de componentes principales con rotación VARIMAX. Los resultados exhiben una aceptable confiabilidad interna de la escala (a = 0.793) y una adecuación satisfactoria de los datos a la matriz factorial (KMO = 0.785). La estructura factorial quedó representada por 17 ítems escalonados en cinco grupos: carga física, ambiente térmico, ruido, riesgos laborales y seguridad en el trabajo. Finalmente, el instrumento confirma una confiabilidad adecuada de gran utilidad para la comprensión e implementación de estrategias de acción en cuanto a la realización de modificaciones en las condiciones de trabajo en el sector para lograr satisfacción entre los empleados.

The Working Conditions Survey was designed and applied as a tool for assessing psychosocial components of job safety in a sample of 518 employees from different companies in the manufacturing sector of the Colombian Caribbean region. Reliability analysis, exploratory factor analysis and principal components analysis with VARIMAX rotation were performed. Results show acceptable internal reliability of the scale (a = 0.793) and satisfactory adequacy of factorial matrix data (KMO = 0.785). The factorial structure was represented by 17 items staggered into five groups: physical load, thermal environment, noise, occupational hazards and safety at work. In conclusion confirms the instrument adequate reliability and structural stability useful for the analysis and design of programs in order to implement changes in working conditions to achieve employee satisfaction.

Características fenotípicas de los pacientes con síndrome de poliposis serrada de colon: estudio de 23 casos / Phenotype characteristics of patients with colonic serrated polyposis syndrome: a study of 23 cases

INTRODUCCIÓN: El síndrome de poliposis serrada (SPS) es una entidad rara caracterizada por la presencia de múltiples pólipos de histología hiperplásica en el colon y un riesgo aumentado de presentar y desarrollar cáncer colorrectal (CCR). OBJETIVO: Evaluar las características clínicas y fenotípicas de los sujetos que reúnen alguno de los 3 criterios de la OMS para el diagnóstico de SPS, diagnosticados y seguidos en nuestro hospital. PACIENTES Y MÉTODOS: Se revisan los pacientes con SPS durante 2005-2012, periodo en el que se realizan 24.208 colonoscopias. Se analizan edad, sexo, historia familiar de CCR (APC/MYH), fenotipo proximal/mixto/distal, indicación de colonoscopia, número, tamaño, localización de los pólipos hiperplásicos, presencia de pólipos mixtos/adenomatosos, CCRI, seguimiento y tratamiento endoscópico/quirúrgico. RESULTADOS: Se han recogido 23 casos (19 hombres). El promedio de edad fue 51 años. El 34% presentaba antecedentes familiares de CCR o pólipos. El fenotipo distal (48%) fue más frecuente. El 73% presentaba pólipos adenomatosos sincrónicamente, y el 26% un CCR. El 57% eran pacientes asintomáticos. Se realizó cirugía en 9 casos (6 por cáncer y 3 por poliposis, y 14 con polipectomías sucesivas y observación). Un total de 11 pacientes (47%) presentaron lesiones recurrentes/persistentes tras el tratamiento quirúrgico/endoscópico inicial. CONCLUSIÓN: El SPS es un síndrome heterogéneo, variable en tipo, tamaño, distribución y número de pólipos, siendo más frecuente en varones fumadores con fenotipo distal. La mayoría de los pacientes presentan además pólipos adenomatosos de manera sincrónica. Estos pacientes requieren una evaluación organizada multidisciplinary

INTRODUCTION: Serrated polyposis síndrome (SPS) is a rare entity characterized by the presence of multiple hyperplastic polyps in the colon and an increased risk of presentation and development of colorectal cancer (CRC). Objetive: To evaluate the clinical and phenotypical characteristics of patients that present one of the 3 WHO criteria for the diagnosis of SPS diagnosed and treated a tour hospital. PATIENTS AND METHODS: Patients with the diagnosis of SPS during 2005-2012 were revised; 24.208 colonoscopies were performed during this period. Age, sex, family history of CRC (APC/MYH), proximal/mixed/distal phenotype, indication for colonoscopy, number, size, location of the hyperplastic polyps, presence of mixed/adenomatous polyps, CRCI, follow-up and endoscopio/surgical treatment. RESULTS: A total of 23 cases were included (19 male). The median age was 51. A total of 34% had a prior family history of CRC or polpyps. Distal phenotype was more frequent (48%). Another 73% presented synchronous adenomatous polyps, and 26% a CRC. A total of 57% were asymptomatic. Surgery was performed in 9 cases (6 for cancer and 3 for polyposis), and 14 were treated by polypectomy and observation. Eleven patients (47%) presented recurrent/persistent lesions after initial surgical/endoscopic treatment. CONCLUSION: SPS is an heterogeneous síndrome that is variable in the type, size, distribution and number of polyps, and is more common in male smokers with a distal phenotype. The majority of patients also present synchronous adenomatous polyps. These patients require an organized multidisciplinary evaluation

Phenotype characteristics of patients with colonic serrated polyposis syndrome: a study of 23 cases.

INTRODUCTION: Serrated polyposis syndrome (SPS) is a rare entity characterized by the presence of multiple hyperplastic polyps in the colon and an increased risk of presentation and development of colorectal cancer (CRC). OBJECTIVE: To evaluate the clinical and phenotypical characteristics of patients that present one of the 3 WHO criteria for the diagnosis of SPS diagnosed and treated a tour hospital. PATIENTS AND METHODS: Patients with the diagnosis of SPS during 2005-2012 were revised; 24.208 colonoscopies were performed during this period. Age, sex, family history of CRC (APC/MYH), proximal/mixed/distal phenotype, indication for colonoscopy, number, size, location of the hyperplastic polyps, presence of mixed/adenomatous polyps, CRCI, follow-up and endoscopio/surgical treatment. RESULTS: A total of 23 cases were included (19 male). The median age was 51. A total of 34% had a prior family history of CRC or polpyps. Distal phenotype was more frequent (48%). Another 73% presented synchronous adenomatous polyps, and 26% a CRC. A total of 57% were asymptomatic. Surgery was performed in 9 cases (6 for cancer and 3 for polyposis), and 14 were treated by polypectomy and observation. Eleven patients (47%) presented recurrent/persistent lesions after initial surgical/endoscopic treatment. CONCLUSION: SPS is an heterogeneous syndrome that is variable in the type, size, distribution and number of polyps, and is more common in male smokers with a distal phenotype. The majority of patients also present synchronous adenomatous polyps. These patients require an organized multidisciplinary evaluation.

Solid catalysts for multistep reactions: one-pot synthesis of 2,3-dihydro-1,5-benzothiazepines with solid acid and base catalysts.

1,5-Benzothiazepines derivatives were obtained first by starting from 1,3-diphenylpropenone derivatives (chalcones) and 2-aminothiophenol by using aluminosilicate solid catalysts. However, diffusional limitations and the strong adsorption of products on the catalyst are deleterious for catalyst activity and life. Then a structured amorphous mesoporous catalyst with large pores and mild acidity that works at higher temperatures allowed us to obtain high conversions (99 %) and selectivities (98 %) of the desired product. A one-pot synthesis of 1,5-benzothiazepines that starts from benzaldehyde, acetophenone, and 2-aminothiophenol with 95 % yield was performed by combining optimized solid base and acid catalysts in batch mode as well as in a continuous-flow reactor system. Much better conversion and selectivity as well as process intensification has been achieved with the structured mesoporous materials by avoiding intermediate and final neutralization and purification steps required in the synthesis reported previously that uses homogeneous catalysts.