1.
J Pediatr
; 132(6): 1036-8, 1998 Jun.
Article
in English
| MEDLINE
| ID: mdl-9627600
ABSTRACT
A 20-month-old boy presented with severe congenital growth hormone, thyrotropin, and prolactin deficiencies resulting from a de novo mutation of the PIT-1 gene. This form of congenital hypopituitarism should be suspected if pituitary anatomy is normal, especially if prolactin levels are low and, in boys, if the external genitalia are normal. Pituitary atrophy appears to be an age-dependent phenomenon in this condition.