Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
ACS Appl Bio Mater ; 4(2): 1720-1730, 2021 02 15.
Article in English | MEDLINE | ID: mdl-35014518

ABSTRACT

This paper reports an approach for the fabrication of shape-changing bilayered scaffolds, which allow the growth of aligned skeletal muscle cells, using a combination of 3D printing of hyaluronic acid hydrogel, melt electrowriting of thermoplastic polycaprolactone-polyurethane elastomer, and shape transformation. The combination of the selected materials and fabrication methods allows a number of important advantages such as biocompatibility, biodegradability, and suitable mechanical properties (elasticity and softness of the fibers) similar to those of important components of extracellular matrix (ECM), which allow proper cell alignment and shape transformation. Myoblasts demonstrate excellent viability on the surface of the shape-changing bilayer, where they occupy space between fibers and align along them, allowing efficient cell patterning inside folded structures. The bilayer scaffold is able to undergo a controlled shape transformation and form multilayer scroll-like structures with cells encapsulated inside. Overall, the importance of this approach is the fabrication of tubular constructs with a patterned interior that can support the proliferation and alignment of muscle cells for muscle tissue regeneration.


Subject(s)
Biocompatible Materials/chemistry , Elastomers/chemistry , Hydrogels/chemistry , Muscle Fibers, Skeletal/chemistry , Printing, Three-Dimensional , Tissue Engineering , Animals , Biocompatible Materials/pharmacology , Cell Survival/drug effects , Cells, Cultured , Elastomers/pharmacology , Extracellular Matrix/chemistry , Hydrogels/pharmacology , Materials Testing , Mice , Tissue Scaffolds/chemistry
SELECTION OF CITATIONS
SEARCH DETAIL
...