Linfoma de Burkitt desarrollado en pacientes con enfermedad de Hodgkin en remisión completa / Burkitt´s lymphoma in a patient with Hodgkin´s disease in full remission

Los pacientes tratados por enfermedad de Hodgkin tiene mayor riesgo de desarrollar una neoplasia secundaria, incluidos los linfomas no Hodgkin. Se describe el caso de un hombre de 38 años con enfermedad de Hodgkin que 16 años después presentó un linfoma de Burkitt gástrico. El paciente empezó a manifestar linfadenopatías supraclavicular y mediastínicas. Fue diagnosticado de enfermedad de Hodgkin tio esclerosis nodular, estadio IV E B que se trató mediante radioterapia y quimioterapia. Se revisó la literatura de los linfomas de Burkitt aparecidos tras enfermedad de Hodgkin en remisión, encontrados 21 casos. La mayoría recibieron radioterapia y quimioterapia, y la localización extranodal más frecuente del linfoma de Burkitt fue el hígado. La media del intervalo desde el diagnóstico de enfemedad de Hodgkin y el diagnóstico de linfoma de Burkitt fue de 91 meses. Los pacientes inmunodeprimidos tienen mayor incidencia de neoplasias linfoides, que incluyen linfomas no Hodgkin, principalmente linfomas de células grandes y linfoma de Burkitt y, posiblemente, enfermedad de Hodgkin (AU)

True histiocytic lymphoma as a second neoplasm in a follicular centroblastic-centrocytic lymphoma.

We report on a patient who developed a true histiocytic lymphoma, 16 years after initial diagnosis of a follicular low grade centroblastic-centrocytic lymphoma with several recurrences. We consider, out of gene rearrangement and immunohistochemical studies, that in this case, true histiocytic lymphoma is a second neoplasm in the evolutive course of the low grade lymphoma. The natural history of a low grade malignant lymphoma is to develop into a high grade large cell lymphoma and, if a second neoplasm appears, it is usually an epithelial tumor. This fact makes our report unique, as it would be, to our knowledge, the first case of true histiocytic lymphoma as the second neoplasm of another lymphoma.

[Lymphoproliferative pathology of the genitourinary tract. Report of 6 cases and review of the literature]. / Patología linfoproliferativa del tracto genitourinario. Aportación de 6 casos y revisión de la literatura.

OBJECTIVES: Six cases of genitourinary lymphoma are described and the literature reviewed. METHODS/RESULTS: The cases had the following histopathological diagnosis: 1 small and large cell non-Hodgkin lymphoma (NHL) of the renal pelvis, 2 high grade centroblastic testicular NHL; 1 centroblastic-centroid bladder NHL, 1 lymphoplasmocytoid bladder NHL and 1 low grade NHL of the prostate. All but the prostatic lymphoma were primary. Treatment was by nephrectomy and chop polychemotherapy (PCT) for the renal pelvis NHL, orchiectomy for the 2 testicular NHLs (one case also received radiotherapy), chop PCT for the bladder NHLs and PCT for the prostatic NHL. Three patients have died: the patient with renal pelvis NHL, centroblastic-centroid bladder NHL and the patient with prostatic NHL. CONCLUSIONS: Although these tumors are rare, they should be suspected in patients with lymphoma, elderly men with a testicular mass, patients with a large bladder compressing/infiltrating mass and in the immunnodepressed patients. A preoperative histopathological diagnosis must be made before performing radical surgery.

Tonsillar metastases: report on two cases and review of literature.

Metastases to the tonsils are extremely infrequent. Less than 70 cases have been reported in literature since 1858. The commonest sources of tonsillar metastases are malignant melanomas and carcinomas of the breast and the lungs. We report about two new cases of tonsillar metastases, one of which developed from a malignant melanoma, the other one from a hepatocellular carcinoma. We have not found any reports on tonsillar metastases stemming from hepatocellular carcinomas in literature and, moreover, in our case, this was the clinical presentation of the primary tumor.

Primary malignant lymphoma of the bladder. Report of three cases.

Primary malignant lymphoma of the bladder is a rare tumour. In a recent literature search only 70 cases have been found since 1885. Most of these tumours were low grade B-cell non Hodgkin's lymphomas and only 20% were high grade neoplasms. This tumour usually appears in women between 20 and 85 years (median 64 yr.) of age. 20% of them have antecedents of chronic cystitic. Some authors have considered that some of the primary malignant lymphomas of the bladder arise from the mucosa-associated lymphoid tissue (MALT), therefore acting like MALT lymphomas which affect the gastrointestinal tract, the salivary glands or the thyroid. We report three additional cases of primary malignant lymphoma of the bladder, two of high grade, and discuss the histological criteria that support their MALT nature.

[Bladder amyloidosis in a female patient with suspected bladder carcinoma]. / Amiloidosis vesical en una paciente con sospecha de carcinoma vesical.

We report on a patient with a long history of rheumatoid arthritis who consulted for intense hematuria that was initially ascribed to carcinoma of the bladder. Subsequent patient evaluation, however, disclosed amyloidosis of the urinary bladder. The literature on amyloidosis of the urinary tract is reviewed. A detailed analysis of the biopsy specimens taken from a lesion that looks like a bladder carcinoma may disclose other pathologies such as amyloidosis of the urinary bladder.