ABSTRACT
The aetiology of septic acute kidney injury (AKI) is not completely elucidated. Early identification of AKI in septic patients is considered to improve survival rate since it allows rapid treatment onset. We evaluated clinical, haematological, urinary, B-mode, spectral Doppler, and contrast-enhanced ultrasound variables in 20 bitches with pyometra as sepsis models and 12 healthy controls. All animals with pyometra presented some degree of renal damage on histological examination; however, sequential organ failure assessment (SOFA) classified only 40% cases with sepsis. AKI derived from systemic infection was identified in 57% of cases with hypoperfusion and in 22% with inflammation, being an affection of multifactorial origin. Among the evaluated parameters, urinary protein/creatinine ratio >0.15, serum albumin <2.94 mg/dL, time-averaged minimum velocity <21.5 cm/s, renal length/aorta diameter ratio >5.93, pulsatility index >1.53, haematocrit <45%, time-averaged maximum velocity <45.7 cm/s, haemoglobin <16 g/dL, leukocytes >12.53 × 103/uL, and cortical contrast peak intensity <69%, in the order of accuracy, are significant indicators of septic AKI with an accuracy >80%. Thus, AKI is a very prevalent condition in septic patients, derived mainly from changes in renal perfusion and inflammation. Additionally, reviewing the SOFA score parameters is suggested to identify renal failure.
Subject(s)
Acute Kidney Injury/diagnosis , Dog Diseases/diagnosis , Kidney/diagnostic imaging , Pyometra/complications , Sepsis/complications , Acute Kidney Injury/diagnostic imaging , Acute Kidney Injury/veterinary , Animals , Case-Control Studies , Creatinine/urine , Dog Diseases/diagnostic imaging , Dogs , Female , Heart Rate , Hematocrit , Kidney/pathology , Organ Dysfunction Scores , Pyometra/veterinary , Sepsis/diagnostic imaging , Sepsis/physiopathology , Serum Albumin/analysis , Ultrasonography, DopplerABSTRACT
O contador automático hematológico ABX Micros ESX 60 (Horiba Medical 2012) é analisador hematológico veterinário multi-espécie que realiza 50 contagens por hora, libera 18 parâmetros sanguíneos, além de fazer representações gráficas (histogramas) para leucócitos, hemácias e plaquetas. O objetivo deste trabalho é avaliar o desempenho do referido aparelho em relação à linearidade e carryover, através de controle comercial e de amostras de sangue provenientes da rotina do Laboratório de Patologia Clínica Veterinária. De acordo com resultados é possível afirmar que o presente aparelho possui um excelente coeficiente de linearidade (r2=0,99) nos parâmetros de leucócitos, eritrócitos e plaquetas em relação às diluições estudadas. Em relação aos carryover houve excelente desempenho do aparelho, contudo, houve valores não conformes nos parâmetros de CHCM e VPM em uma das metodologias realizadas que pode ser justificada pela limitação da fórmula que não considera a características do equipamento.(AU)
The automated hematology counter ABX Micros 60 ESX (Horiba Medical 2012) is veterinary hematology analyzer multi-species that carries 50 counts per hour releases 18 blood parameters, in addition to graphical representations (histograms) for leukocytes, erythrocytes and platelets. The objective of this study is to evaluate the performance of the apparatus with respect to linearity and carryover through commercial control and blood samples from the routine of Veterinary Clinical Pathology Laboratory. According to results we can say that this device has excellent linearity coefficient (r2=0.99) in leukocyte parameters, erythrocytes and platelets during that time dilutions. Regarding the carryover was excellent device performance, however, was not in conformity values ââin the parameters of MCHC and VPM in one of the methodologies made that can be justified by the limited formula that does not consider the equipment characteristics.(AU)
Subject(s)
Erythrocyte Count/instrumentation , Hematologic Tests/instrumentation , Hematologic Tests/veterinary , Leukocyte Count/instrumentation , Platelet Count/instrumentation , Blood Cell Count/veterinaryABSTRACT
O trabalho teve como objetivo o relato de caso de um cão com fibrossarcoma, com metástase pulmonar e cardíaca, macho, sem raça definida, dois anos de idade, que apresentava como sinais clínicos aumento de volume ulcerado na região metacarpiana do membro torácico esquerdo de aproximadamente sete centímetros de diâmetro. Como exames complementares foram realizados hemograma, bioquímica sanguínea sérica, ultrassonografia abdominal e radiografia das regiões torácicas e metacarpiana do membro afetado, sem alterações significativas...
