ABSTRACT
Background People affected by Human Immunodeficiency Virus (HIV), are burdened by a higher risk of developing malignancies including non-melanoma skin cancer (NMSC) and melanoma skin cancer. Objective To evaluate the association of HIV with melanoma and NMSC at a University Hospital. Methods This is a cross-sectional retrospective study of HIV-infected and a matched comparison group, analyzing the associations between skin cancer and HIV infection. Results Compared to the HIV-uninfected, HIV-infected had 80% association with skin cancer (CI 95%: 1.3-2.4, P = 0.001) The risk was 45-fold higher by patients" age (CI 95%: 3.3-15.9: P = 0.001). When adjusted for patient age, sex and race, the risk was 6.4 fold ligher of having cancer if compared to the others (CI 95%: 49-84, P = 0.001). Melanoma was not found in HIV-infected. Conclusion With this study, we have demonstrated that HIV-infected patients have an increased risk of BCC and SCC. Preventive dermatologic management is pivotal in the care of immunosuppressed patients. These patients must undergo the dermatological examination annually and should receive extensive counseling regarding sun avoidance, use of sunscreens,and sun-protective clothing.
Subject(s)
Carcinoma, Basal Cell , Carcinoma, Squamous Cell , HIV Infections , Melanoma , Skin Neoplasms , Humans , HIV Infections/complications , HIV Infections/diagnosis , HIV Infections/epidemiology , Carcinoma, Basal Cell/complications , Retrospective Studies , Cross-Sectional Studies , Carcinoma, Squamous Cell/diagnosis , Carcinoma, Squamous Cell/epidemiology , Carcinoma, Squamous Cell/etiology , Skin Neoplasms/diagnosis , Skin Neoplasms/epidemiology , Skin Neoplasms/etiology , Melanoma/diagnosis , Melanoma/epidemiology , Melanoma/complications , Risk FactorsSubject(s)
Alopecia , Cicatrix , Alopecia/complications , Alopecia/surgery , Cicatrix/complications , Cicatrix/surgery , Hair , Hair Follicle/pathology , Humans , Skin TransplantationABSTRACT
O angiossarcoma é uma rara neoplasia vascular originada das células endoteliais. É muito agressivo com alta taxa de recorrência, metástases precoces e mau prognóstico. O diagnóstico precoce do angiossarcoma é um desafio, pois muitas vezes apresenta-se como uma equimose ou pápula violácea que pode ser confundida com lesão benigna como um hemangioma. O tamanho do tumor é um fator prognóstico importante e o diagnóstico precoce e tratamento combinado são fundamentais para aumentar a sobrevida desses pacientes. Esse estudo relata o caso de um homem de 58 anos de idade com angiossarcoma de couro cabeludo altamente agressivo e prognóstico reservado. (AU)
Angiosarcoma of the head and neck is a rare vascular sarcoma associated with high rates of local recurrence and distant metastasis and a poor prognosis. The diagnosis of cutaneous angiosarcoma can be challenging because it often presents insidiously as a bruiselike lesion or a purplish papule thatmay be mistaken for a benign lesion such as hemangioma. The tumor size is a important prognostic factor and a multimodality treatment approach is imperative for successful outcomes. This study reports the case of 58-years-man with angiosarcoma of the scalp aggressive and a poor prognosis. (AU)
