ABSTRACT
BACKGROUND: Elderly patients may be less likely than younger patients to receive indicated therapy. We hypothesized that older patients with papillary thyroid carcinoma (PTC) would be less likely to receive total thyroidectomy (TT) than their younger counterparts. MATERIALS AND METHODS: The Surveillance, Epidemiology, and End Results database were queried for adult patients diagnosed with PTC from 2000 through 2009. Patients were categorized according to whether they received a TT or less than a total thyroidectomy (Subject(s)
Carcinoma, Papillary/surgery
, Healthcare Disparities
, Thyroid Neoplasms/surgery
, Thyroidectomy/methods
, Adolescent
, Adult
, Age Factors
, Aged
, Aged, 80 and over
, Female
, Follow-Up Studies
, Humans
, Male
, Middle Aged
, Prognosis
, SEER Program
, Young Adult
ABSTRACT
We report two BODIPY based photosensitizers (Br2BOAc and I2BOAc) featuring an acetoxymethyl substituent at the meso-position. These photosensitizers show improved photostability against singlet oxygen, when compared to a BODIPY photosensitizer lacking the acetoxymethyl group. Both compounds were evaluated for photodynamic therapy against HeLa cells and photodynamic inactivation against E. coli bacteria. We show that the compounds readily embed in the lipid membranes of HeLa cervical cancer cells and efficiently induced light-dependent apoptosis at nanomolar concentration. Also, both compounds showed a substantial degree of photoinactivation of E. coli bacteria when used at low micromolar concentrations.
Subject(s)
Boron Compounds/chemistry , Photosensitizing Agents/chemistry , Photosensitizing Agents/pharmacology , Apoptosis/drug effects , Apoptosis/radiation effects , Escherichia coli/drug effects , HeLa Cells , Humans , Light , Microscopy, Fluorescence , Photobleaching , Singlet Oxygen/chemistry , Spectrophotometry, UltravioletABSTRACT
Quality assurance in colon cancer demands a multidisciplinary effort involving general practitioners, surgeons, radiologists, gastroenterologists, medical oncologists, and pathologists, among others. Maximal improvements in survival will result when colon cancer screening, diagnosis, staging, treatment and surveillance are optimized. We seek to identify those issues most relevant to the quality of care we provide our colon cancer patients.
