ABSTRACT
We present a new case of porokeratosis plantaris palmaris et disseminata (PPPD), observe in it a histological picture of cornoid lamella in palms, soles, arms, legs and trunk. In this dermatosis, mediant lectins and involucrin to establish keratinocytes alteration. The immunohistochemical studies have reveals not normal formation in the envelope cornea, and fundamentally D-galactose show a marked diminution in the cell membrane.
Subject(s)
Hand Dermatoses/pathology , Keratoderma, Palmoplantar/pathology , Leg Dermatoses/pathology , Adult , Biopsy , Female , Humans , Immunohistochemistry , Lectins , Protein Precursors , SpainABSTRACT
A case is reported of cutaneous leishmaniasis with an ultrastructural study of the amastigote form, emphasizing and discussing the presence of two flagella inwards in the same parasite, a fact which is indicative of the great activity of the parasite in host lesions.
Subject(s)
Leishmania tropica/ultrastructure , Leishmaniasis/pathology , Animals , Humans , Microscopy, ElectronABSTRACT
We have studied biopsies of lesional skin with monoclonal and polyclonal antibodies to determine the nature of the infiltrate in different forms of psoriasis. In guttate psoriasis the number of Langerhans cells (LC) was not increased and CD8+ cells predominated, however, most CD4+ cells were activated. In erythrodermal psoriasis some CDI+ cells were found in the dermis although CD8+ cells predominated and were activated. In palmo-plantar psoriasis LC were found in the epidermis and superficial dermis and CD4+ cells were more numerous than CD8+ cells, some in turn expressing HLA-DR. In flexural psoriasis the LC formed clusters in the epidermis, and activated CD4+ cells predominated. In psoriasis vulgaris CD4+ cells predominated over CD8+ although the latter were activated. Our observations tend to support Valdimarsson's hypothesis on the immune basis of psoriasis, but we believe that two cycles coexist in psoriasis--one inflammatory and the other immunological--and that interaction between these leads to epidermal hyperproliferation.
Subject(s)
Antigens, Differentiation, T-Lymphocyte/analysis , Psoriasis/immunology , Skin/immunology , Adolescent , Adult , CD4-Positive T-Lymphocytes/immunology , Female , Humans , Immunoenzyme Techniques , Langerhans Cells/pathology , Lymphocyte Activation , Male , Middle Aged , Psoriasis/pathologyABSTRACT
Lectin application is used to study 12 cases of ichthyosis, 8 cases of Darier's disease and two of acrokeratosis verruciformis, establishing comparative patterns with normal skin.
Subject(s)
Darier Disease/pathology , Ichthyosis/pathology , Keratosis/pathology , Lectins , Staining and Labeling , Humans , Ichthyosis/classification , Keratins/metabolism , Skin/analysisABSTRACT
An evaluation is made of the clinical and histological parameters of 650 cases of spinocellular epithelioma. The statistical analysis shows tumor relapse to be related to tumor size, evolution time, relapse following previous treatments, earlier cutaneous lesions, Broders' grading, acantholysis, inflammatory infiltrate and type of treatment applied.
Subject(s)
Carcinoma, Squamous Cell/pathology , Neoplasm Recurrence, Local , Skin Neoplasms/pathology , Biopsy , Carcinoma, Squamous Cell/therapy , Humans , Neoplasm Recurrence, Local/etiology , Risk Factors , Skin Neoplasms/therapy , Spain , Time FactorsABSTRACT
Lectins are used to study four cases of keratosis pilaris, four of lichen spinulosus, 11 of porokeratosis, 8 of striated lichen and one case of pityriasis rubra pilaris, with the aim of providing data to improve knowledge of the histogenesis of these processes.
Subject(s)
Keratins/metabolism , Lectins/metabolism , Skin Diseases/etiology , Humans , Keratosis/etiology , Keratosis/metabolism , Keratosis/pathology , Phytohemagglutinins/metabolism , Pityriasis Rubra Pilaris/etiology , Pityriasis Rubra Pilaris/metabolism , Pityriasis Rubra Pilaris/pathology , Ricin/metabolism , Skin Diseases/metabolism , Skin Diseases/pathologyABSTRACT
A study is made of the state of cell and humoral immunity in patients with genital warts. The results show an increase in the T-suppressor lymphocyte population (T8+) (p less than 0.011) of these patients, which reduces the T-helper/T suppressor ratio (T4 +/T8 +). No alterations are observed in the humoral immunity on analyzing seric immunoglobulin concentration (IgA, IgG, IgM), complement factors (C3, C4), or their functionality (CH50).
