ABSTRACT
BACKGROUND: Thioredoxins (TRX) are major cellular protein disulphide reductases that are critical for redox regulation. Oxidative stress and inflammation play promoting roles in the genesis and progression of atherosclerosis, but until now scarce data are available considering the influence of TRX activity in familial combined hyperlipidaemia (FCH). Since FCH is associated with high risk of cardiovascular disease, the objective of the present study was to assess oxidative stress status in FCH patients, and evaluate the influence of insulin resistance (IR). MATERIALS AND METHODS: A cohort of 35 control subjects and 35 non-related FCH patients were included, all of them nondiabetic, normotensive and nonsmokers. We measured lipid profile, glucose and insulin levels in plasma, and markers of oxidative stress and inflammation such as oxidized glutathione (GSSG), reduced glutathione (GSH) and TRX. RESULTS: Familial combined hyperlipidaemia subjects showed significantly higher levels of GSSG, GSSG/GSH ratio and TRX than controls. In addition, FCH individuals with IR showed the worst profile of oxidative stress status compared to controls and FCH patients without IR (P < 0·01). TRX levels correlated with higher insulin resistance. CONCLUSION: Familial combined hyperlipidaemia patients showed increased TRX levels. TRX was positively correlated with IR. These data could partially explain the increased risk of cardiovascular events in primary dyslipidemic patients.
Subject(s)
Glutathione Disulfide/metabolism , Glutathione/metabolism , Hyperlipidemia, Familial Combined/metabolism , Insulin Resistance , Thioredoxins/metabolism , Adult , Blood Glucose/metabolism , Cardiovascular Diseases/metabolism , Case-Control Studies , Cholesterol, HDL/metabolism , Cholesterol, LDL/metabolism , Female , Humans , Male , Middle Aged , Oxidative Stress , Triglycerides/metabolismABSTRACT
INTRODUCCIÓN: La desnutrición hospitalaria es un problema de alta prevalencia que afecta a la morbimortalidad de los pacientes, lo que comporta una mayor estancia y un incremento de los costes sanitarios. Aunque no existe un único método de despistaje nutricional, la valoración subjetiva global (VSG) puede ser una herramienta útil, económica y fácilmente reproducible. Métodos Estudio transversal, observacional y aleatorio realizado en 197 pacientes de un hospital terciario. Se utilizó la VSG y se determinaron datos antropométricos y parámetros bioquímicos para evaluar el estado nutricional de los pacientes estudiados. Resultados El porcentaje de sujetos desnutridos fue del 50% según la VSG. Se observó una mayor prevalencia de desnutrición en los servicios médicos (53%) que en los quirúrgicos (47%). La mitad de los sujetos estudiados (50%) presentó desnutrición mediante la VSG, de los cuales solo un 37,5% recibió tratamiento nutricional durante su estancia hospitalaria. La estancia media de los pacientes desnutridos (13,5 días) o en riesgo de desnutrición (12,1 días) fue mayor que la de aquellos sujetos bien nutridos (6,97 días). La VSG se correlacionó de forma significativa (p < 0,012) con los parámetros antropométricos y bioquímicos de desnutrición. Conclusiones La prevalencia de desnutrición hospitalaria es muy alta, tanto en servicios médicos como quirúrgicos y, sin embargo, es incorrectamente tratada. La VSG es una herramienta útil de despistaje de desnutrición hospitalaria por su alto grado de correlación con parámetros bioquímicos y antropométricos
INTRODUCTION: Hospital malnutrition is a highly prevalent problem that affects patient morbidity and mortality resulting in longer hospital stays and increased healthcare costs. Although there is no single nutritional screening method, subjective global assessment (SGA) may be a useful, inexpensive, and easily reproducible tool. Methods A cross-sectional, observational, randomized study was conducted in 197 patients in a tertiary hospital. SGA, anthropometric data, and biochemical parameters were used to assess the nutritional status of study patients. Results Fifty percent of subjects were malnourished according to SGA. A higher prevalence of malnutrition was found in medical (53%) as compared to surgical departments (47%). Half the subjects (50%) had malnutrition by SGA, but only 37.8% received nutritional treatment during their hospital stay. Mean hospital stay was longer for patients malnourished (13.5 days) or at risk of malnutrition (12.1 days) as compared to well nourished subjects (6.97 days). SGA significantly correlated (P < .012) with anthropometric and biochemical malnutrition parameters. Conclusions Prevalence of hospital malnutrition is very high in both medical and surgical departments and is inadequately treated. SGA is a useful tool for screening hospital malnutrition because of its high degree of correlation with anthropometric and biochemical parameters
Subject(s)
Humans , Malnutrition/epidemiology , Hospitalization/statistics & numerical data , Nutrition Assessment , /statistics & numerical data , Anthropometry/methods , Body Weights and MeasuresABSTRACT
INTRODUCTION: Hospital malnutrition is a highly prevalent problem that affects patient morbidity and mortality resulting in longer hospital stays and increased healthcare costs. Although there is no single nutritional screening method, subjective global assessment (SGA) may be a useful, inexpensive, and easily reproducible tool. METHODS: A cross-sectional, observational, randomized study was conducted in 197 patients in a tertiary hospital. SGA, anthropometric data, and biochemical parameters were used to assess the nutritional status of study patients. RESULTS: Fifty percent of subjects were malnourished according to SGA. A higher prevalence of malnutrition was found in medical (53%) as compared to surgical departments (47%). Half the subjects (50%) had malnutrition by SGA, but only 37.8% received nutritional treatment during their hospital stay. Mean hospital stay was longer for patients malnourished (13.5 days) or at risk of malnutrition (12.1 days) as compared to well nourished subjects (6.97 days). SGA significantly correlated (P<.012) with anthropometric and biochemical malnutrition parameters. CONCLUSIONS: Prevalence of hospital malnutrition is very high in both medical and surgical departments and is inadequately treated. SGA is a useful tool for screening hospital malnutrition because of its high degree of correlation with anthropometric and biochemical parameters.
