ABSTRACT
Propusemo-nos verificar as alteraçöes em protozoários do gênero Giardia e da mucosa duodenal de camundongos portadores deste parasito, após tratamento com Flagil e com nosódio giardinum
Subject(s)
Animals , Mice , Giardiasis , Homeopathic RemedyABSTRACT
Em trabalhos anteriores GIAZZI e Cols já haviam demonstrado a presença de ácaros e amebas de vida livre em poeiras domiciliares. Autores como Pessoa e Martins além de Neves citam que estas pequenas amebas, cujo havitat normal é o solo e a água, podem tornar-se parasitas facultativos do homem e determinar-lhe uma meningoencefalite rápida e fatal
Subject(s)
Homeopathy , MitesABSTRACT
In the present study we describe the morphological and morphometric alterations induced by Bolivia strain of the Trypanosoma cruzi in the mouse parotid gland during the acute period of infection. The acinar cells exhibit reduced eosinophilia, greater chromatin condensation, reduced height and consequent dislocation of the nucleus towards the basal pole. Then lumen is reduced. The ducts are dilated and lined with low cylindrical epithelium. The septa are wider. An intense lymphoplasmocytic infiltrate is present. Amastigotes was found in glandular acini cells, striated duct cells, inter and intralobular connective tissue, muscle walls of blood vessels, and inside the striated duct lumen.
Subject(s)
Chagas Disease/pathology , Parotid Gland/pathology , Acute Disease , Animals , MiceABSTRACT
In the present study we describe the morphological and morphometric alterations induced by Trypanosoma cruzi (Bolivia strain) on the mice parotid gland, and the action of cocaine on the development of the gland of growing infected animals. The acinar cells of animals inoculated 28 d after birth showed reduced eosinophilia, greater chromatin condensation, reduced height, and basally dislocated nucleus. The area occupied by the acini was decreased and the nuclear volume was reduced. Reduced height of epithelial cells and decreased nuclear volume occurred in the striated and excretory ducts. The presence of lymphoplasmocyte infiltrates was also observed. The present results indicate delayed development of the infected mouse parotid gland. Our results indicate that cocaine perceptibly reduced the atrophy of the acinar cells and minimized the histopathological changes caused by T. cruzi in the parotid gland, in addition to significantly increasing the survival of infected animals. The presence of stroma with dilated capillaries and frequent inflammatory infiltrates showed that cocaine does not interfere with the inflammatory response.
Subject(s)
Chagas Disease/pathology , Cocaine/pharmacology , Neurotoxins/metabolism , Trypanosoma cruzi/metabolism , Animals , Atrophy , Male , Mice , Neurotoxins/biosynthesis , Parotid Gland/pathologySubject(s)
Chagas Disease/pathology , Salivary Glands/parasitology , Animals , Male , Mice , Salivary Glands/pathologyABSTRACT
In the present study we describe the morphological and morphometric alterations induced by two Trypanosoma cruzi strains (strains Y and Bolivia) in the mouse parotid gland during the subpatent period of infection. The acinar cells of animals inoculated 27 d after birth showed reduced eosinophilia, greater chromatin condensation, reduced height, and basally dislocated nucleus. The area occupied by the acini was decreased (999.38 micron 2 to 546.76 micron 2) and the volume of the acinar cells was reduced (116.28 micron 3 to 63.28 micron 3). Reduced height (21.20 micron to 14.28 micron) and decreased nuclear volume (125.28 micron 3 to 77.28 micron 3) occurred in the striated ducts. In the excretory duct there was reduced nuclear volume (121.16 micron 3 to 76.14 micron 3) and decreased height of the epithelial cells (26.05 micron to 14.00 micron). The presence of lymphoplasmocyte infiltrates was also observed. The changes induced by the Bolivia strain were qualitatively similar to those induced by strain Y, but more severe in nature. The present results indicate that infection with T. cruzi induces delayed development of the mouse parotid gland during the subpatent phase.
Subject(s)
Chagas Disease/pathology , Parotid Gland/pathology , Animals , Cell Nucleus/ultrastructure , Karyometry , Male , Mice , Parotid Gland/ultrastructureSubject(s)
Chagas Disease/metabolism , Parotid Gland/analysis , Animals , Chagas Disease/pathology , Histocytochemistry , Male , Mice , Parotid Gland/pathologyABSTRACT
Os autores verificaram atrofia da glandula sublingual de camundongos infectados experimentalmente pelo Trypanosoma cruzi, na fase da parasitemia maxima. As modificacoes morfologicas e histologicas foram: atrofia das celulas acinosas, com acidofilia reduzida e nucleos mais densos e diminuicao da concentracao das sialomucinas
