[Autoradiographic study of the action of yohimbine on rat spermatogenesis]. / Avtoradiografichno prouchvane deistvieto na iokhimbina vurkhu spermatogenezata na plukh.

The authors found an increase in the number of labelled spermatogonia and spermatocytes with 35 to 40% in the experimental animals as a result of performed quantitative studies on mature male rats after chronic treatment with jochimbin and simultaneous application of 3H-thymidine. This statistically significant difference in comparison with the control animals showed that jochimbin stimulated the mitotic activity of spermatogonia as a result of which the number of spermatozoa was increased and the whole process of spermatogenesis was affected. The biologic action of jochimbin on the spermatogenesis of a rat was similar to that of the preparation TB-68, examined by us.

[Effect of preparation TB-68 on spermatopoiesis in rats (autoradiographic study)]. / Vliianie na preparata TB-68 vurkhu spermatopoeazata na plukh (avtoradiografichni izsledvaniia

Male mature rats were treated per of with TB-68 and intraperitonealy with 3H-thymidine during 7 and 12 days. By means of statistical count of labelled cells in semi niferous tubules a considerable increase of DNA replicating cells in experimental animals was established. The higher percentage of labelled calls reveales an stimulating effect of TB-68 concerning the spermatogonial proliferation, some acceleration of the meiosis and positive influence of the spermatopoiesis as a whole.