ABSTRACT
Meyerson nevi occur whenever a rare focal and transitory eczematous eruption arises around melanocytic lesions. The same phenomenon has also been observed in non-melanocytic lesions as well. Herein we report the case of a 25 year old, male patient, who had noticed, two months before, the arising of a pruriginous and erithematous halo around two nevi localized on his abdomen. The lesions were found to be atypical on dermoscopic examination and he was submitted to surgical excision of both nevi. Histopathological examination revealed displastic compound melanocytic nevi, surrounded by intraepidermical vesicles and spongiosis. Present report suggests that Meyerson phenomenon does not seem to alter dermoscopic features of nevi.
Subject(s)
Nevus, Pigmented/pathology , Skin Neoplasms/pathology , Abdominal Wall , Adult , Dermoscopy , Humans , MaleABSTRACT
O nevo de Meyerson ocorre quando uma rara erupção eczematosa focal e transitória surge ao redor de lesões melanocíticas. O mesmo fenômeno também foi observado em lesões não melanocíticas. O caso relatado é o de um doente masculino, 25 anos, que há dois meses notara surgimento de eritema e prurido, circundando dois nevos, localizados no abdome. As lesões eram atípicas à dermatoscopia e procedeu-se à excisão cirúrgica dos dois nevos. O exame histopatológico revelou nevos melanocíticos compostos displásicos, envolvidos por espongiose e vesículas intraepidérmicas. O presente relato sugere que o fenômeno de Meyerson não modifica as características dermatoscópicas dos nevos.
Meyerson nevi occur whenever a rare focal and transitory eczematous eruption arises around melanocytic lesions. The same phenomenon has also been observed in non-melanocytic lesions as well. Herein we report the case of a 25 year old, male patient, who had noticed, two months before, the arising of a pruriginous and erithematous halo around two nevi localized on his abdomen. The lesions were found to be atypical on dermoscopic examination and he was submitted to surgical excision of both nevi. Histopathological examination revealed displastic compound melanocytic nevi, surrounded by intraepidermical vesicles and spongiosis. Present report suggests that Meyerson phenomenon does not seem to alter dermoscopic features of nevi.
Subject(s)
Adult , Humans , Male , Nevus, Pigmented/pathology , Skin Neoplasms/pathology , Abdominal Wall , DermoscopyABSTRACT
BACKGROUND: The non- or low-sedating H1 receptor antagonists represent the basic therapy for urticaria. OBJECTIVE: To test an alternative approach to patients unresponsive to conventional treatment. MATERIALS AND METHODS: A total of 22 patients with chronic urticaria unresponsive to conventional antihistamine treatment were enrolled for this study. They had uncontrolled urticaria even using multiple combinations of antihistamines on maximum doses and corticosteroids in short cycles (prednisone 20-40 mg, per os once a day, 3-7 days per month). Cutaneous biopsies of the urticaria lesions were taken. These findings were classified as: (I) a mixture of perivascular dermal inflammatory infiltrate composed of lymphocytes, monocytes and neutrophils and/or eosinophils; (II) inflammatory infiltrate composed chiefly of neutrophils; and (III) inflammatory infiltrate composed mainly of eosinophils. According to histology, the patients were submitted to one of the following therapeutic schemes: class A - antihistamine treatment plus dapsone; class B - colchicine or dapsone; class C - montelukast. RESULTS: Four patients in class A, 08 in class B and seven in class C displayed complete control of urticaria after 12 weeks of treatment; one patient in class B and two in class C did not respond to treatment. Two years after discontinuation, 16 patients are still free of urticaria. CONCLUSIONS: This study suggests an alternative approach for treating unresponsive chronic urticaria.
Subject(s)
Anti-Infective Agents/therapeutic use , Histamine H1 Antagonists/therapeutic use , Leukotriene Antagonists/therapeutic use , Tubulin Modulators/therapeutic use , Urticaria/drug therapy , Urticaria/pathology , Acetates/therapeutic use , Adult , Chronic Disease , Colchicine/therapeutic use , Cyclopropanes , Dapsone/therapeutic use , Drug Therapy, Combination , Female , Humans , Male , Middle Aged , Quinolines/therapeutic use , SulfidesABSTRACT
Foi analisado o perfil de 247 doentes com eritrodermia em um período de 23 anos, de janeiro de 1962 a março de 1985, com o período de seguimento variando de 1 a 26 anos. Os doentes se apresentavam com eritema universal, descamaçäo e prurido com mais de 2 meses de duraçäo e a idade variava de 16 a 60 anos. A psoríase foi a doença associada mais freqüente, com uma proporçäo estimada de 44,9 por cento, as reaçöes cutâneas ao uso de drogas contribuíram com 7,3 por cento do total de casos e a associaçäo com reticuloses mostrou uma proporçäo de 4,1 por cento. A eritrodermia permaneceu como de causa desconhecida em 29,2 por cento dos casos. Näo foram observadas diferenças entre os sexos no que diz respeito à doença associada. Um ou mais resultados anátomo patológicos das biópsias de pele, em conjunto com o quadro clínico, foi diagnóstico ou sugestivo do diagnóstico da doença associada em 63,6 por cento dos casos. Recomendam-se biópsias de pele seriadas como o melhor método para a elucidaçäo diagnóstica da eritrodermia. Ao nível de significância P=0,05, foi encontrada uma proporçäo homem/mulher em 2 : 1. Especula-se se o agente causal da eritrodermia estaria relacionado à exposiçäo diferenciada entre os sexos a antígenos do meio ambiente
Subject(s)
Humans , Incidence , Dermatitis, Exfoliative/epidemiology , Retrospective Studies , Dermatitis, Exfoliative/classification , Dermatitis, Exfoliative/complications , Psoriasis/complicationsABSTRACT
Este comparativo entre oito diferentes fórmulas fotoprotetoras foi realizado em 20 voluntários com exposiçäo ao UVB com 10 DME para avaliar a melhor eficácia quanto aos veículos gel, creme e loçäo. Os resultados obtidos demonstraram que o gel foi o que conferiu maior fotoproteçäo do que as fórmulas com creme ou loçäo
