ABSTRACT
The X chromosome is a singular source of information in population genetics, anthropological research and in forensic cases. Thus, many researchers have been interested in characterizing X chromosome markers in different populations. The Brazilian Genetic Database of Chromosome X (BGBX--Banco Genético Brasileiro do Cromossomo X) website is freely available in Portuguese and English versions and was developed with the main purpose of compiling all Brazilian population genetic data for X chromosome short tandem repeats (X-STRs) markers published in scientific journals searchable via PubMed. Furthermore, this database presents other relevant information concerning X-STRs, such as genetic and physical locations, allele structure, nomenclature, mutation rates, primers described in the literature and likelihood ratio calculation. The entire scientific community is now encouraged to submit their X-STR population genetic data to this website, available at http://www.bgbx.com.br. Regarding future prospects of BGBX, the authors intend to expand the website with data and information of X-linked insertion-deletion polymorphisms.
Subject(s)
Chromosomes, Human, X/genetics , Databases, Genetic , Alleles , Brazil , Genetics, Population , Haplotypes , Humans , INDEL Mutation , Internet , Polymorphism, GeneticSubject(s)
Chromosomes, Human, Y/genetics , Haplotypes , Microsatellite Repeats , Brazil , DNA Fingerprinting , Gene Frequency , Genetic Variation , Humans , MaleABSTRACT
The genetic markers most commonly utilized to determine identity and in paternity testing are autosomal short tandem repeats (STRs); to interpret the DNA analysis, the results of a case have to be compared with a pertinent reference population. Thus, the aim of this work was to characterize the genetic profile of the population of Araraquara (São Paulo, Brazil) by analyzing 15 STR loci included in the PowerPlex(®) 16 System and to correlate these data with the migration history of the population. No deviations from the Hardy-Weinberg equilibrium were observed for any of the loci, after Bonferroni's correction. Forensic parameters exhibited high values, the most polymorphic loci being Penta E, D18S51 and FGA. An unweighted pair-group method with arithmetic mean (UPGMA) tree based on genetic distances showed that the current population of Araraquara is grouped with populations of the southeastern region of Brazil, which are close to the European group but distant from African and Amerindian populations. Estimates of admixture components revealed that the contributions to the population of Araraquara were 76% European, 18% African, and 6% Amerindian.
