Effectiveness of digital home rehabilitation and supervision for stroke survivors: A systematic review and meta-analysis.

Objective: Stroke survivors often experience residual impairments and motor decline post-discharge. While digital home rehabilitation combined with supervision could be a promising approach for reducing human resources, increasing motor ability, and supporting rehabilitation persistence there is a lack of reviews synthesizing the effects. Thus, this systematic review and meta-analysis aimed to synthesize the effect of digital home rehabilitation and supervision in improving motor ability of upper limb, static balance, stroke-related quality of life, and self-reported arm function among stroke survivors. Methods: Six electronic databases, grey literature, ongoing studies, and reference lists were searched for relevant studies. Two investigators independently reviewed titles, abstracts, screened full texts for eligibility and performed data extraction. Meta-analysis of 13 independent studies were grouped into four separate meta-analyses. The Grading of Recommendations, Assessments, Development and Evaluations (GRADE) tool was used for evaluating the overall quality of the evidence. Results: Meta-analyses showed no statistically significant difference between intervention (digital home rehabilitation) and control groups (home training/clinic-based) of all outcomes including motor ability of upper limb, static balance, stroke-related quality of life, and self-reported arm function. In the sub-group analysis digital home rehabilitation was associated with better quality of arm use (standardized mean difference = 0.68, 95% confidence interval: [0.27, 1.09], p = 0.001). Conclusions: This result indicated that digital home rehabilitation has similar effects and could potentially replace home training or clinic-based services. This review highlights better-targeted digital motor interventions to examine the effects of interventions further. The quality of evidence was moderate to high in motor and self-reported arm outcomes, and low for balance and quality of life.

Image quality with iterative reconstruction techniques in CT of the lungs-A phantom study.

BACKGROUND: Iterative reconstruction techniques for reducing radiation dose and improving image quality in CT have proved to work differently for different patient sizes, dose levels, and anatomical areas. PURPOSE: This study aims to compare image quality in CT of the lungs between four high-end CT scanners using the recommended reconstruction techniques at different dose levels and patient sizes. MATERIAL AND METHODS: A lung phantom and an image quality phantom were scanned with four high-end scanners at fixed dose levels. Images were reconstructed with and without iterative reconstruction. Contrast-to-noise ratio, modulation transfer function, and peak frequency of the noise power spectrum were measured. RESULTS: IMR1 Sharp+ and VEO improved contrast-to-noise ratio to a larger extent than the other iterative techniques, while maintaining spatial resolution. IMR1 Sharp+ also maintained noise texture. CONCLUSIONS: IMR1 Sharp+ was the only reconstruction technique in this study which increased CNR to a large extent, while maintaining all other image quality parameters measured in this study.

Average glandular dose in paired digital mammography and digital breast tomosynthesis acquisitions in a population based screening program: effects of measuring breast density, air kerma and beam quality.

The main purpose was to compare average glandular dose (AGD) for same-compression digital mammography (DM) and digital breast tomosynthesis (DBT) acquisitions in a population based screening program, with and without breast density stratification, as determined by automatically calculated breast density (Quantra™). Secondary, to compare AGD estimates based on measured breast density, air kerma and half value layer (HVL) to DICOM metadata based estimates. AGD was estimated for 3819 women participating in the screening trial. All received craniocaudal and mediolateral oblique views of each breasts with paired DM and DBT acquisitions. Exposure parameters were extracted from DICOM metadata. Air kerma and HVL were measured for all beam qualities used to acquire the mammograms. Volumetric breast density was estimated using Quantra™. AGD was estimated using the Dance model. AGD reported directly from the DICOM metadata was also assessed. Mean AGD was 1.74 and 2.10 mGy for DM and DBT, respectively. Mean DBT/DM AGD ratio was 1.24. For fatty breasts: mean AGD was 1.74 and 2.27 mGy for DM and DBT, respectively. For dense breasts: mean AGD was 1.73 and 1.79 mGy, for DM and DBT, respectively. For breasts of similar thickness, dense breasts had higher AGD for DM and similar AGD for DBT. The DBT/DM dose ratio was substantially lower for dense compared to fatty breasts (1.08 versus 1.33). The average c-factor was 1.16. Using previously published polynomials to estimate glandularity from thickness underestimated the c-factor by 5.9% on average. Mean AGD error between estimates based on measurements (air kerma and HVL) versus DICOM header data was 3.8%, but for one mammography unit as high as 7.9%. Mean error of using the AGD value reported in the DICOM header was 10.7 and 13.3%, respectively. Thus, measurement of breast density, radiation dose and beam quality can substantially affect AGD estimates.

How Different Iterative and Filtered Back Projection Kernels Affect Computed Tomography Numbers and Low Contrast Detectability.

OBJECTIVE: The aim of this study was to evaluate how different iterative and filtered back projection kernels affect the computed tomography (CT) numbers and low contrast detectability. METHODS: Five different scans were performed at 6 different tube potentials on the same Catphan 600 phantom using approximately the same dose level and otherwise identical settings. The scans were reconstructed using all available filtered back projection body kernels and with iterative reconstruction techniques. RESULTS: The CT numbers and the contrast-to-noise ratios were reported and how they are affected by the kernel choice and strength of iterative reconstruction. CONCLUSIONS: Iterative reconstruction improved contrast-to-noise ratio in most cases, but in certain situations, it decreased it. Variations in CT numbers can be large between kernels with similar sharpness for certain densities.

Image texture and radiation dose properties in CT.

The aim of this study was to compare image noise properties of GE Discovery HD 750 and Toshiba Aquilion ONE. The uniformity section of a Catphan 600 image quality assurance phantom was scanned with both scanners, at different dose levels and with extension rings simulating patients of different sizes. 36 datasets were obtained and analyzed in terms of noise power spectrum. All the results prove that introduction of extension rings significantly altered the image quality with respect to noise properties. Without extension rings, the Toshiba scanner had lower total visible noise than GE (with GE as reference: FC18 had 82% and FC08 had 80% for 10 mGy, FC18 had 77% and FC08 74% for 15 mGy, FC18 had 80% and FC08 77% for 20 mGy). The total visible noise (TVN) for 20 and 15 mGy were similar for the phantom with the smallest additional extension ring, while Toshiba had higher TVN than GE for the 10 mGy dose level (120% FC18, 110% FC08). For the second and third ring, the GE images had lower TVN than Toshiba images for all dose levels (Toshiba TVN is greater than 155% for all cases). The results indi-cate that GE potentially has less image noise than Toshiba for larger patients. The Toshiba FC18 kernel had higher TVN than the Toshiba FC08 kernel with additional beam hardening correction for all dose levels and phantom sizes (120%, 107%, and 106% for FC18 compared to 110%, 98%, and 97%, for FC08, for 10, 15 and 20 mGy doses, respectively).

Choosing the best reconstruction technique in abdominal computed tomography: a systematic approach.

OBJECTIVE: There is uncertainty regarding the effect of iterative reconstruction (IR) techniques and other reconstruction algorithms on image quality. The aim of this study was to optimize image quality in relation to radiation dose in computed tomography (CT) liver examinations by comparing images reconstructed with different abdominal filters with and without IR. METHODS: An anthropomorphic phantom was scanned on a Toshiba Aquilion ONE CT scanner. Images at 2 different dose levels were reconstructed with 12 different body reconstruction filters, all with both filtered back-projection and Adaptive Iterative Dose Reduction 3 dimensional. Receiver operating characteristic curves were constructed. The 2 reconstruction combinations with the highest scores from the phantom study were evaluated in a second comparison of clinical images. Six liver examinations were reconstructed with both filters and evaluated using visual grading analysis. RESULTS: Two combinations of reconstruction filters and IR were the only 2 options among the 8 best images at both dose levels (area under the curve, 0.96 and 0.94 for 15 mGy as well as 0.86 and 0.84 for 10 mGy). In the patient study, one of these filters in combination with IR scored slightly higher than the other in combination with IR (mean score, 2.60 and 2.57, respectively; P = 0.56). Iterative reconstruction did not significantly increase lesion detectability for any of the filters. CONCLUSIONS: This study indicates that the preferred choice for reconstruction of CT liver examinations performed with the Toshiba Aquilion ONE should be the FC18 filter with IR, although the IR technique did not significantly improve lesion detectability and did not compensate for the dose reduction in this study.

How to measure CT image quality: variations in CT-numbers, uniformity and low contrast resolution for a CT quality assurance phantom.

PURPOSE: Quality assurance (QA) phantoms for testing different image quality parameters in computed tomography (CT) are commercially available. Such phantoms are also used as reference for acceptance in the specifications of CT-scanners. The aim of this study was to analyze the characteristics of the most commonly used QA phantom in CT: Catphan 500/504/600. METHODS: Nine different phantoms were scanned on the same day, on one CT-scanner with the same parameter settings. Interphantom variations in CT-number values, image uniformity and low contrast resolution were evaluated for the phantoms. Comparisons between manual image analysis and results obtained from the automatic evaluation software QAlite were performed. RESULTS: Some interphantom variations were observed in the low contrast resolution and the CT-number modules of the phantoms. Depending on the chosen regulatory framework, the variations in CT-numbers can be interpreted as substantial. The homogenous modules were found more invariable. However, the automatic image analysis software QAlite measures image uniformity differently than recommended in international standards, and will not necessarily give results in agreement with these standards. CONCLUSIONS: It is important to consider the interphantom variations in relation to ones framework, and to be aware of which phantom is used to study CT-numbers and low contrast resolution for a specific scanner. Comparisons with predicted values from manual and acceptance values should be performed with care and consideration. If automatic software-based evaluations are to be used, users should be aware that large differences can exist for the image uniformity testing.

Iterative reconstruction reduces abdominal CT dose.

OBJECTIVE: In medical imaging, lowering radiation dose from computed tomography scanning, without reducing diagnostic performance is a desired achievement. Iterative image reconstruction may be one tool to achieve dose reduction. This study reports the diagnostic performance using a blending of 50% statistical iterative reconstruction (ASIR) and filtered back projection reconstruction (FBP) compared to standard FBP image reconstruction at different dose levels for liver phantom examinations. METHODS: An anthropomorphic liver phantom was scanned at 250, 185, 155, 140, 120 and 100 mAs, on a 64-slice GE Lightspeed VCT scanner. All scans were reconstructed with ASIR and FBP. Four readers evaluated independently on a 5-point scale 21 images, each containing 32 test sectors. In total 672 areas were assessed. ROC analysis was used to evaluate the differences. RESULTS: There was a difference in AUC between the 250 mAs FBP images and the 120 and 100 mAs FBP images. ASIR reconstruction gave a significantly higher diagnostic performance compared to standard reconstruction at 100 mAs. CONCLUSION: A blending of 50-90% ASIR and FBP may improve image quality of low dose CT examinations of the liver, and thus give a potential for reducing radiation dose.

Interphantom and interscanner variations for Hounsfield units--establishment of reference values for HU in a commercial QA phantom.

In computer tomography (CT) diagnostics, the measured Hounsfield units (HU) are used to characterize tissue and are in that respect compared to nominal HU values found in the radiological literature. Quality assurance (QA) phantoms are commercially available with a variety of tissue substitutes and materials to test the HU values in CT. It is however recognized from CT physics that the HU for a given material is energy dependent and may vary substantially between scanners. The aim of this study is to analyze the characteristics of a commonly used QA phantom, the Catphan 500/600 (The Phantom Laboratory, NY). Four CT phantoms were scanned on one CT scanner to examine possible interphantom variations in HU values. Secondly, one selected phantom was scanned at three kVp levels on eight different CT scanners. The interphantom variations in HU values were small, in the range 2-5 HU. The interscanner variations were however substantial, in the range 7-56 HU depending on energy and material. Varying the x-ray energy produced a shift in the measured HU of up to 79 HU on one scanner. Reference HU values for the eight sensitometric test materials in Catphan are provided for eight CT scanner models from four vendors. The reference HU values are provided for 80, 120 and 140 kVp. Our results suggest that scanner-independent threshold levels for HU should be used only with extreme caution. Tissue characterization can be used provided that a scanner-specific data set for normal and abnormal is determined.

[Radiation protection of childrens' chest during high resolution CT of the lungs]. / Strålebeskyttelse av barns bryst ved høyoppløselig CT av lungene.

BACKGROUND: The Norwegian Radiation Protection Authority recommends bismuth to protect radiosensitive surface organs during CT imaging. A study based on the use of phantoms was therefore initiated to investigate the usefulness of this protection on the breasts of young girls undergoing high-resolution computed tomography (HRCT) of the chest. MATERIAL AND METHODS: Shields covered with one, two or three layers of bismuth were placed on a homogenous phantom. CT numbers (pixel values in the images which describe the density of the tissue imaged), noise and artifacts were evaluated from the images of the phantom. Dosimeters were used for dose measurements in an anthropomorphic phantom of a child. RESULTS: Areas close to the shield in the images of the phantom had CT numbers up to 33 % higher with two and three layers of bismuth than in the images without shielding. With one layer the CT numbers were up to 8 % higher. Noise in the same area was up to 56 % higher with two and three layers of bismuth than without, and up to 14 % higher with one layer. The surface dose in the breast region was reduced with 30 % with one layer of bismuth, 45 % with two and 75 % with three layers of bismuth. INTERPRETATION: Shielding with one layer of bismuth seems to have little effect on the CT images. The Department of pediatric radiology at Ullevaal University Hospital now uses bismuth protection with one layer as a routine during HRCT of girls up to 16 years of age.

[Pelvimetry with compute tomography]. / Bekkenmåling med computertomografi.

BACKGROUND: In 1993, Ullevaal University Hospital started CT pelvimetry. The accuracy of CT pelvimetric measurements and a low fetal dose are very important. In our study we tested the accuracy of CT pelvimetry and measured the fetal dose and the effective dose to the mother. METHOD: A lead scalar was exposed in different heights compared to the isocentre. Measurements were done at front and side scout views and compared to the real scale. Dose estimates were done in CT dosimetry (NRPB). Effective doses to patient as well as fetal doses were measured in this study. Fetal dose was estimated as uterus dose. RESULTS: Our results show that the measurements are overestimates when the table is moved away from the isocentre against the tube. If the table is moved away from the tube and against the detector, the measurements are underestimates. The measurements in the isocentre are accurate. This means that CT pelvimetric measurements are accurate if the patient is placed in the isocentre. In our study the estimated fetal dose was 0.74 mGy and mother's effective dose was 0.3 mSv. INTERPRETATION: Our results show that the fetal dose is as low or lower than with conventional pelvimetry. The CT pelvimetric measurements are accurate if they are performed on patients in the isocentre. We recommend that CT pelvimetry replace conventional pelvimetry.