[Tumor-associated hetero-organic antigens as markers of deranged cell differentiation and malignancy]. / Opukholeassotsiirovannye geteroorgannye antigeny kak markery disdifferentsirovki i malignizatsii kletok.

We used rat liver tissue slices and isolated hepatocytes to demonstrate that single exposures to a "weak" carcinogen 4-dimethylaminoazobenzol (DAB) or to a "strong" one, such as N-diethylnitrosamine (DENA), cause identical antigenic restructuring to occur. It presented as formation of membranous heteroorganic antigens of renal origin on hepatocyte surfaces. Antigens were associated with Zajdela's hepatoma; their synthesis lasted longer after exposure to DENA. They, however, were not identified in intact rat liver. Their synthesis, following single exposure, was assayed immunocytofluorimetrically. It is suggested that the antigens be used as markers of cell dysdifferentiation and malignancy and testing substances for carcinogenicity.

[Phytotherapy of the sensitization state caused by metal allergens]. / Fitoterapiia sostoianiia sensibilizatsii, vyzvannoi metallami-allergenami.

Experimental study revealed noticeable desensibilization caused by the use of medicinal herbs collections in laboratory animals sensibilized by chromium and nickel. That desensibilization effect of herbal medications is believed to result from activation and normalization of processes removing the agents from the body. Revealed experimentally and supported by clinical trials, therapeutic efficiency of the medicinal herbs collections makes them applicable for treatment and prophylaxis of allergies associated with metals.

[Evaluation of the morphofunctional status of peripheral blood cells using the GTsMK-3 hemocytometer]. / Otsenka morfofunktsional'nogo sostoianiia kletok perifericheskoi krovi na gemotsitometru GTsMK-3.

The suggested complex method for assessment of red blood cell and leukocyte counts and membranous function helps assess the time course of cellular membrane and peripheral blood status from the minimal volumes of the blood by precise estimation of cell loss using conductometry.

[Standardization of di-chlor-di-para-xylilene, di-bromine-di-para-xylilene and di-para-xylilene]. / Materialy k reglamentirovaniiu di-khlor-di-para-ksililena, di-brom-di-para-ksililena i di-para-ksililena.

Studied were the new components of dielectric coatings: di-para-xylilene, di-bromine-di-para-xylilene, dichlor-di-para-xylilene, which manifested themselves as low-toxicity compounds free from irritating, sensitizing and fibrogenous effects. The acute action thresholds for aerosols of the paraxylilenes were established at 10 mg/m3 (with regard to general and embryotoxicity), at 5 mg/m3 for the maximal inactive concentrations.