ABSTRACT
Studies of the structural changes of erythrocytic phospholipids and their free-radical oxidation in health and intrauterine hypoxia in 61 parturients and their fetuses have shown that, despite a variety of causes of intrauterine hypoxia, the structural changes of fetal red cells are virtually the same and present as enlarged crystals and more marked crystallization of the phospholipid layer of the membrane. These structural changes occur in the presence of lipid peroxidation activation and antioxidant system insufficiency.
Subject(s)
Erythrocyte Membrane/physiology , Fetal Hypoxia/blood , Adolescent , Adult , Crystallography, X-Ray , Erythrocyte Membrane/chemistry , Female , Humans , Infant, Newborn , Lipid Peroxidation , Membrane Lipids/blood , Phospholipids/blood , Pregnancy , Pregnancy Complications/bloodABSTRACT
The study was concerned with the evaluation of effect of the extract of a human fetal organ, the umbilical cord, on development and growth of such transplantable tumors as Ehrlich's ascites tumor, sarcoma 37, sarcoma 180 and Zajdela's hepatoma as well as of dimethylbenzanthracene- and benzo(a)pyrene-induced cancer. In a subgroup of animals who had been vaccinated once or twice prior to inoculation of cells, a significant inhibition of growth of tumors of all the histologies except sarcoma 180 was observed alongside with a decrease in tumor incidence and partial resorption of ascitic fluid. Preliminary vaccination of rats interfered with dimethylbenzanthracene- and benzo(a)pyrene-induced carcinogenesis reducing tumor incidence and assuring longer latent period and slower progression of cancer.
