[Electrophysiologic effects of serotonin on atrioventricular conduction in dogs]. / Elektrofiziologicheskoe deistvie serotonina na atrioventrikuliarnuiu provodimost' u sobak.

In 12 anaesthetized dogs acute effects of serotonin on the atrioventricular conduction system were studied by obtaining intracardiac electrograms. The significant increase in the heart rate and decrease in aortic pressure elicited by an intravenous infusion of 50 mg/kg.min serotonin for 30 minutes were comparable to those observed in previous investigations. Our data indicate a serotonin induced acceleration of the sinus node pacemaker and atrioventricular conduction by direct and indirect mechanisms.

[Hemodynamic effect of a mitral valve prosthesis]. / Gemodinamicheskii éffekt protezirovaniia mitral'nogo klapana.

Hemodynamic findings are analysed in 113 patients with different types of mitral prosthesis. Catheterization of the heart was carried out before the operation and during the late post-operative period. The gradient through the prosthesis was estimated for patients with different types of mitral valve prosthesis during the operation. According to our data, the tilting-disc valve prosthesis MKC-59 and the ball valve prosthesis MKC-25 are associated with the best gradients. Mitral prosthesis improves hemodynamic activity, but does not normalize it. The heart index remains lowered, while the pressure inside the pulmonary capillaries and pulmonary artery remains elevated, as compared to normal levels. Signs of mitral stenosis become more apparent during exercise.

[Diagnosis of acute pulmonary artery embolism]. / Diagnostika ostroi émbolii legochnoi arterii.

The clinical picture and the electrocardiographic and rheopneumographic findings were compared with the data obtained during operation or angiopneumography in 31 patients with embolism of the pulmonary artery. In massive embolism of the pulmonary artery, the dominating clinical symptoms were sudden dyspnea, tachycardia and cyanosis. Collapse and cardiac arrest were encountered in most patients. Moderate embolism is characterized by advancing dyspnea but cyanosis and tachycardia are inconsistant symptoms. The results of electrocardiography and rheopneumography are in correlation with the data obtained in catheterization of the heart, angiopneumography and during embolectomy.

[Diagnosis of paravalvular fistulae after mitral valve prosthesis]. / O diagnostike paraval'vuliarnykh fistul posle protezirovaniia mitral'nogo klapana.

The phonocardiography method is appraised and the correlative dependence of the data yielded by it is compared with the hemodynamic values in the diagnosis of paravalvular fistulas following mitral valve prosthetics in 11 patients. It was revealed that the duration of the interval from the sound of aortic closure to the sound of mitral opening is in close reverse relation (r = -0.61) with the level of the mean pulmonary-capillary pressure: the shorter the interval, the more severe is the disorder of hemodynamics in patients with paravalvular mitral insufficiency and the higher is the mean pulmonary-capillary pressure. Paravalvular fistulas in the 11 patients examined were manifested by the development of a systolic murmur.

[Clinical aspects of circulatory disorders in the vertebral arteries and the possibilities for their surgical treatment]. / Nekotorye klinicheskie aspekty narushenii krovoobrashcheniia v pozvonochnykh arteriiakh i vozmozhnosti ikh khirurgicheskogo lecheniia.

Experience in the follow-up of 84 patients who underwent operation for transient cerebral vascular insufficiency in the vertebro-basilar bed is summarized. It was found that most patients with abnormally tortuous or anomalously branching vertebral arteries had transient disorders of the carciac rhythm or increased arterial pressure. Operative treatment of such patients contributes to correction of the neurologic symptoms and leads to normalization of the cardiac rhythm and arterial pressure.

[Remote results of multivalvular prostheses in patients with acquired heart defects]. / Otdalennye rezul'taty mnogokratnogo protezirovaniia u bol'nykh priobretennymi porokami serdtsa

The authors examined remote results in 57 patients who had had multivalvular prostheses placed: 35-with mitral and tricuspid valve prostheses, 10-with mitral and aortic valves and 3-with replacement of all 3 valves. Observation period lasted from 3 months to 5 years. Positive results were seen in 42 patients (73.6%). Mortality rate was 21.5%. The main cause of lethal outcomes was myocardial insufficiency in the majority of patients with mitral and aortic prostheses.