ABSTRACT
OBJECTIVE: Interstitial Cystitis (IC) is a chronic and rare disease, more frequent in women. Symptoms of continuous pain can produce psychological disorders, such as anxiety and depression. The spread of COVID-19 pandemic added to distress experienced by patients with IC emotions, such as fear, sadness, boredom, frustration and anger. MATERIALS AND METHODS: A research on very recent literature outlines the necessity for patients facing the complexity of IC during the COVID-19 outbreak to prevent the temporary crisis, to broaden perspectives, to deal with confusion, to support in struggling with unpleasant and unexpected events. CONCLUSIONS: People affected by IC have a psychological vulnerability that needs tailored support interventions, particularly in the COVID era. A multidisciplinary approach offers a personalized treatment through a web-mediated counseling intervention for patients and their caregivers: a space for continuous discussion and reflection can favour a relationship-based process of change aimed at an improvement in quality of life.
Subject(s)
Anxiety/psychology , COVID-19/psychology , Cystitis, Interstitial/psychology , Distance Counseling/methods , Emotions , Internet-Based Intervention , SARS-CoV-2 , Female , Humans , Surveys and QuestionnairesABSTRACT
Tacrine [9-amino-1,2,3,4-tetrahydroacridine] (THA), a potent acetylcholinesterasic inhibitor, is utilized in the pharmacological treatment of Alzheimer's disease (Birne and Arie, 1994). Cytopharmacology of THA is still largely to be discovered. In the present paper we report some effects produced by THA on murine neuroblastoma cells (N2A) used as an experimental model. N2A cells treated with THA at low concentration (1 mu M) showed a reduced cell's mitosis and a remarkable reduction of protein synthesis. Eventually, a marked reduction on the phosphorylation of proteins associated to neurofilaments 200 kD, is observed using specific antibody.
