ABSTRACT
The paper presents new results of embryonic tissue transplantation. Twenty-seven embryonic tissue transplantations into affected regions of brain cortex were performed on 21 patients with apallic syndrome. Motor and mental improvement were observed in sixteen recipients.
Subject(s)
Brain Tissue Transplantation/methods , Fetal Tissue Transplantation/methods , Motor Cortex/transplantation , Persistent Vegetative State/surgery , Child , Humans , Motor Cortex/embryology , Persistent Vegetative State/diagnosis , Persistent Vegetative State/etiology , Syndrome , Treatment OutcomeABSTRACT
Children and adolescents with an unfavourable course of epilepsy received a multiple modality treatment including complamin (xantinolnicotinate). Thirty of the 36 patients showed positive response which was twice as much as in patients receiving only anticonvulsive drugs. The study of the cerebral hemodynamics with the help of regional cerebral blood flow determination by means of intravenous administration of 133Xe and REG showed a tendency to normalization of the vascular supply to the brain. In 66 of the 87 epileptic patients studied the employment of diazepam improved the microcirculation of the cerebral tissue and the venous outflow from the cranial cavity which allows the recommendation of diazepam as a vasoactive agent.
Subject(s)
Cerebrovascular Disorders/drug therapy , Diazepam/therapeutic use , Epilepsy/complications , Theophylline/analogs & derivatives , Xanthinol Niacinate/therapeutic use , Adolescent , Anticonvulsants/therapeutic use , Brain/blood supply , Cerebrovascular Disorders/physiopathology , Child , Drug Therapy, Combination , Epilepsy/physiopathology , Female , Humans , Male , Plethysmography, Impedance , Regional Blood Flow , Xenon RadioisotopesABSTRACT
The results of the multiple-modality treatment of epilepsy in 56 children of different age with the use of thiopental-sodium are presented. It has been shown that its early administration to children with a true status epilepticus makes it possible to faster bring the patient out of the pathologic condition as compared to the conventional methods of treatment. In patients with a symptomatic epistatus and in children with marked residual-organic cerebral insufficiency associated with the development of convulsions anticonvulsive therapy should be combined with the treatment of the underlying disease aimed at the correction of extra- and intracranial homeostasis.
Subject(s)
Status Epilepticus/drug therapy , Thiopental/therapeutic use , Adolescent , Brain Diseases/complications , Child , Child, Preschool , Clinical Trials as Topic , Combined Modality Therapy , Critical Care , Electroencephalography , Female , Humans , Infant , Infant, Newborn , Male , Monitoring, Physiologic , Status Epilepticus/diagnosis , Status Epilepticus/etiologyABSTRACT
133Xe clearance and REG were used in 90 children and adolescents with epilepsy to study pMK, pMCC and the responsiveness of the cerebral vessels in the interparoxysmal period. If the disease takes a relatively favourable course, there is a compensatory intensification of the blood flow in the area of epileptic foci whereas in patients with an unfavourable course, marked chronic dyscirculatory hypoxia and disorders of the responsiveness of the cerebral vessels indicate the decompensation of the vascular component and, possibly, the primary organically induced insufficiency of the brain blood supply.
