[Effect of occlusal form in buccal cusps of molars on masticatory function and intraoral food flow].

PURPOSE: The degree of crushing and intraoral food flow was evaluated using peanuts by the occlusal forms of a removable bridge as indices to clarify the occlusal formative effect of maxillary molars on masticatory function. METHODS: The subject was a 29-year-old male without any gnathostomatic disorders and his removable bridge ([7] 6 [5]) was so made in interocclusal distance as to be 0.5, 1.0 or 1.5 mm from 0 mm standard having occlusal contact to antagonist. Then the subject was asked to chew 3 g of peanuts in a series of unilateral chewing schemes consisting of 5, 10, and 20 masticatory strokes each. The pool rate in the buccal oral vestibule and lingual proper oral cavity as an index of food flow was calculated as the weight of peanut particles accumulated in each side as a percentage of the total volume of recovered peanut particles. Also, the degree of crushing was calculated as the weight of peanut particles that passed through 10-mesh sieves as a percentage of the total weight in each side. RESULTS: As the interocclusal distance to the mandibular cusp increased with abrasion on the inside at maxillary buccal cusps, the pool rate of the buccal oral vestibule was significantly increased and correspondingly that of the lingual proper oral cavity was decreased. The degree of crushing indicated non-significances statistically among 0, 0.5, and 1.0 mm and significantly decreased in 1.5 mm as compared with 0 mm. CONCLUSION: As the interocclusal distance to mandibular cusps from the maxillary inside of buccal cusps was increased, the pool rate of the crushed peanuts in the buccal side increased and the pool rate of crushed peanuts in the lingual side decreased, and the particles showed a comparatively low degree of crushing. It is clear that maxillary buccal occlusion has an effect on the crushing function and food flow.

The effects of bitter melon (Momordica charantia) extracts on serum and liver lipid parameters in hamsters fed cholesterol-free and cholesterol-enriched diets.

The hypolipidemic effect of dietary methanol fraction (BMMF) extracted from bitter melon (Koimidori variety), at the levels of 0.5% and 1.0%, was examined in male golden Syrian hamsters fed diets supplemented with and without cholesterol. The feeding of BMMF at 0.5% and 1.0% levels in the diets for 4 wk tended to reduce food intake and growth, although there was no difference in food efficiency (weight gain/food intake). An effect of dietary BMMF on serum triglyceride was not seen in hamsters fed diets free of cholesterol, while hypertriglyceridemia induced by dietary cholesterol was significantly lowered in a dose-dependent manner in those fed diets containing the BMMF Serum total cholesterol concentration also tended to decrease in a dose-dependent manner following feeding of increasing amounts of BMMF in the presence and absence of cholesterol in the diet. The effects of dietary BMMF on liver triglyceride and total cholesterol levels were marginal, although dietary cholesterol caused a marked accumulation of these lipid molecules in the liver. These results suggest that the BMMF contains some components that could ameliorate lipid disorders such as hyperlipidemia.

The effects of bitter melon (Momordica charantia) on serum and liver triglyceride levels in rats.

Effects of three different varieties (Koimidori, Powerful-Reishi, and Hyakunari) of bitter melon (Momordica charantia) and those of methanol fraction extract of Koimidori variety on serum and liver triglycerides were studied in rats. Feeding of diets containing either bitter melon or various fractions isolated by organic solvents caused no adverse effects on food intake or growth of rats. When the effect of three different varieties of bitter melon was compared, the Koimidori variety was found to be the most effective in lowering hepatic triglyceride levels as compared to the other two varieties, suggesting a variety-dependent difference in their activity. Furthermore, the active component(s) responsible for the liver triglyceride lowering activity of Koimidori variety was assumed to be concentrated in the methanol fraction, but not in other fractions such as the n-hexane, the acetone, or the residual fraction. The triglyceride lowering activity was furthermore confirmed by the dose-dependent reduction of hepatic triglyceride, resulting the lowest level in rats fed 3.0% supplementation. In these experiments, the effects on serum lipids were marginal. The results of the present and previous studies clearly show that bitter melon, especially Koimidori variety, exhibits a potent liver triglyceride-lowering activity.