Subject(s)
Blister/chemically induced , Drug-Related Side Effects and Adverse Reactions , Sweat Gland Diseases/chemically induced , Sweat Glands/drug effects , Sweat Glands/pathology , Acute Disease , Adult , Antibiotics, Antineoplastic/adverse effects , Antimetabolites, Antineoplastic/adverse effects , Cytarabine/adverse effects , Drug Eruptions/etiology , Humans , Idarubicin/adverse effects , Leukemia, Myeloid/therapy , Male , Necrosis , Remission InductionABSTRACT
Nevus lipomatosus cutaneus superficialis (NLCS) is a rare developmental anomaly characterized by isolated ectopic mature adipose tissue in the dermis. We describe a child with a NLCS present from birth that was growing in size. The lesion was removed by simple excision and has not recurred.
Subject(s)
Adipose Tissue , Choristoma/pathology , Lipomatosis/pathology , Nevus/pathology , Skin Neoplasms/pathology , Child , Choristoma/surgery , Female , Humans , Lipomatosis/surgery , Nevus/surgery , Skin Neoplasms/surgeryABSTRACT
BACKGROUND: Extramedullary hematopoiesis is a well-documented manifestation of chronic myeloproliferative disorders, most commonly seen in chronic idiopathic myelofibrosis (agnogenic myeloid metaplasia), but rarely in chronic myelogenous leukemia. It typically occurs in the spleen and liver, but has also been described in skin. Microscopically, foci of extramedullary hematopoiesis consist of erythroid and myeloid precursors intermixed with megakaryocytes. The megakaryocytes may elaborate fibrogenic cytokines, which induce proliferation of fibroblasts. The term 'sclerosing extramedullary hematopoietic tumor' has been applied to this latter entity and its resemblance to a fibrohistiocytic neoplasm has been noted. METHODS: We report the case of a 66-year-old man, whose cutaneous sclerosing extramedullary hematopoietic tumor preceded the diagnosis of chronic myelogenous leukemia.
