1.
J Chromatogr
; 465(2): 422-8, 1989 Mar 31.
Article
in English
| MEDLINE
| ID: mdl-2745607
2.
High-performance liquid chromatographic assay of codeine in acetaminophen with codeine dosage forms.
J Pharm Sci
; 69(9): 1081-4, 1980 Sep.
Article
in English
| MEDLINE
| ID: mdl-7411414
ABSTRACT
An accurate, rapid, and specific high-performance liquid chromatographic (HPLC) assay was developed for codeine in acetaminophen with codeine combination products. The internal standard (chlorpheniramine maleate), codeine, acetaminophen, and several other test compounds or impurities were well separated. A complete analysis took < 10 min. The relative standard deviations of the retention time, precision, and accuracy were 0.5, 0.4, and 0.5%, respectively. An excellent linear correlation was obtained between the HPLC and GLC methods.