ABSTRACT
We have studied 27 clinical records of patients with piriform sinus epidermoid carcinoma diagnosed and treated in our department during a period of 6 years. All the patients underwent surgery and radiotherapy. We have analyzed the survival and recurrence rates together with other parameters that may have some influence in them. We have tried to show the factors that might be in relation with the prognosis of pyriform sinus carcinoma. The statistical analysis show a survival rate of 29.6% after 5 years follow up, being the node invasion, wither clinical or histological, the main fact to have a prognostic value.
Subject(s)
Carcinoma/mortality , Hypopharyngeal Neoplasms/mortality , Aged , Carcinoma/secondary , Carcinoma/therapy , Humans , Hypopharyngeal Neoplasms/pathology , Hypopharyngeal Neoplasms/therapy , Lymphatic Metastasis , Male , Middle Aged , Neoplasm Recurrence, Local/epidemiology , Retrospective Studies , Survival AnalysisABSTRACT
Lectin application is used to study 12 cases of ichthyosis, 8 cases of Darier's disease and two of acrokeratosis verruciformis, establishing comparative patterns with normal skin.
Subject(s)
Darier Disease/pathology , Ichthyosis/pathology , Keratosis/pathology , Lectins , Staining and Labeling , Humans , Ichthyosis/classification , Keratins/metabolism , Skin/analysisABSTRACT
An evaluation is made of the clinical and histological parameters of 650 cases of spinocellular epithelioma. The statistical analysis shows tumor relapse to be related to tumor size, evolution time, relapse following previous treatments, earlier cutaneous lesions, Broders' grading, acantholysis, inflammatory infiltrate and type of treatment applied.
Subject(s)
Carcinoma, Squamous Cell/pathology , Neoplasm Recurrence, Local , Skin Neoplasms/pathology , Biopsy , Carcinoma, Squamous Cell/therapy , Humans , Neoplasm Recurrence, Local/etiology , Risk Factors , Skin Neoplasms/therapy , Spain , Time FactorsABSTRACT
A study is made of the state of cell and humoral immunity in parenteral drug addicts both with and without genital warts. The results reveal alterations in the lymphocyte subpopulations, with a decrease in the T-helper/T-suppressor (T4+/T8+) ratio of both groups of patients. These alterations were more pronounced in those patients with genital warts (p less than 0.05). The alterations in humoral immunity, expressed as a hypergammaglobulinemia IgG and IgM, were similar in both groups. None of the immunological parameters were affected by the extension of the lesions, though the T4+/T8+ ratio was found to decrease with increasing length evolution of the lesions. It would be convenient to perform longitudinal studies of these preliminary data to evaluate the effect of human papilloma virus (HPV) on the immune system.
Subject(s)
Condylomata Acuminata/immunology , Substance-Related Disorders/immunology , T-Lymphocytes/immunology , Adult , CD4-Positive T-Lymphocytes/immunology , Condylomata Acuminata/complications , Female , Humans , Immunoglobulin G/analysis , Immunoglobulin M/analysis , Male , Substance-Related Disorders/complications , T-Lymphocytes, Helper-Inducer/immunology , T-Lymphocytes, Regulatory/immunologyABSTRACT
A study is made of the state of cell and humoral immunity in patients with genital warts. The results show an increase in the T-suppressor lymphocyte population (T8+) (p less than 0.011) of these patients, which reduces the T-helper/T suppressor ratio (T4 +/T8 +). No alterations are observed in the humoral immunity on analyzing seric immunoglobulin concentration (IgA, IgG, IgM), complement factors (C3, C4), or their functionality (CH50).
