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Clin Respir J ; 15(9): 1019-1024, 2021 Sep.
Article in English | MEDLINE | ID: mdl-34087062

ABSTRACT

In this work, we provide an up-to-date summary of the available molecular- and cell-related mechanisms by which alpha1-antitrypsin (AAT) protein could be of benefit in treating COVID-19 patients. As well, we demonstrate the current status in terms of the ongoing clinical trials using AAT in COVID-19 patients. Finally, we touch on the potential role gene therapy and stem cell-based gene therapy could have in such emerging and serious condition caused by the SARS-CoV-2 virus.


Subject(s)
COVID-19 , alpha 1-Antitrypsin Deficiency , Humans , SARS-CoV-2 , alpha 1-Antitrypsin/genetics , alpha 1-Antitrypsin Deficiency/genetics , alpha 1-Antitrypsin Deficiency/therapy
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