ABSTRACT
No disponible
Subject(s)
Humans , Female , Middle Aged , Chemical and Drug Induced Liver Injury/etiology , Garcinia cambogia/toxicity , Plant Extracts/toxicity , Plants, Medicinal/chemistry , Plant Preparations/chemistry , Plant Preparations/toxicity , Plants, MedicinalSubject(s)
Anti-Obesity Agents/adverse effects , Chemical and Drug Induced Liver Injury/etiology , Garcinia cambogia/adverse effects , Chemical and Drug Induced Liver Injury/diagnosis , Diagnosis, Differential , Dietary Supplements/adverse effects , Female , Hepatitis, Viral, Human/diagnosis , Humans , Middle AgedABSTRACT
Acute-on-Chronic Liver Failure (ACLF) is a recently introduced term defined as severe acute deterioration of an established liver disease. This entity usually develops after an acute insult. The main clinical manifestations are hepatorenal syndrome, hepatic encephalopathy and organ failure, with a high risk of death in the short term.The true incidence of ACLF remains difficult to determine due to confusions surrounding the definition of this entity, but seems to be 40% at 5 years in patients with advanced cirrhosis, which translates into 4,000 cases in Europe within this time span.The treatment of choice is liver transplantation. However, due to the shortage of suitable organs and morbidity and mortality in these patients, other options must be used (AU)
Acute-on-Chronic Liver Failure (ACLF) es una entidad de reciente introducción que se define como un deterioro agudo y grave de una hepatopatía crónica conocida. Suele aparecer tras un acontecimiento precipitante agudo. Sus principales manifestaciones clínicas son el síndrome hepatorrenal, la encefalopatía hepática y el fracaso orgánico, y comporta un elevado riesgo de muerte a corto plazo.La incidencia de ACLF, aunque es difícil dar cifras por su confusa definición, parece ser del 40% a los 5 años en pacientes con cirrosis avanzada, lo que implica más de 4.000 casos en Europa durante este período.El trasplante hepático se plantea como la terapéutica de elección en estos casos; no obstante, la falta de suficientes órganos adecuados para trasplante y la morbimortalidad del trasplante en pacientes en esta situación hacen que nos veamos obligados a tratar a estos pacientes con opciones distintas al trasplante (AU)
Subject(s)
Humans , Liver Failure , Dialysis , Europe/epidemiology , Liver Failure/complications , Liver Failure/therapy , Liver Failure, Acute/therapy , Liver TransplantationABSTRACT
Acute-on-Chronic Liver Failure (ACLF) is a recently introduced term defined as severe acute deterioration of an established liver disease. This entity usually develops after an acute insult. The main clinical manifestations are hepatorenal syndrome, hepatic encephalopathy and organ failure, with a high risk of death in the short term. The true incidence of ACLF remains difficult to determine due to confusions surrounding the definition of this entity, but seems to be 40% at 5 years in patients with advanced cirrhosis, which translates into 4,000 cases in Europe within this time span. The treatment of choice is liver transplantation. However, due to the shortage of suitable organs and morbidity and mortality in these patients, other options must be used.
