1.
Biosci Biotechnol Biochem
; 80(10): 1966-9, 2016 Oct.
Article
in English
| MEDLINE
| ID: mdl-27101707
ABSTRACT
The hemolytic lectin CEL-III forms transmembrane pores in the membranes of target cells. A study on the effect of site-directed mutation at Lys405 in domain 3 of CEL-III indicated that replacements of this residue by relatively smaller residues lead to a marked increase in hemolytic activity, suggesting that moderately destabilizing domain 3 facilitates formation of transmembrane pores through conformational changes.