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1.
J Antibiot (Tokyo) ; 70(1): 45-51, 2017 Jan.
Article in English | MEDLINE | ID: mdl-27599768

ABSTRACT

The novel antifungal agent ASP2397 (Vical's compound ID VL-2397) is produced by the fungal strain MF-347833 that was isolated from Malaysian leaf litter and is identified here as an Acremonium species based on its morphology, physiological properties and 28S ribosomal DNA sequence. Because of its potential importance for producing novel antifungal agents, we determined the taxonomic and biologic properties of MF-347833. We show here that ASP2397 is a cyclic hexapeptide that chelates aluminum ion and is therefore similar to ferrichrome, a hydroxamate siderophore. However, ASP2397 differs structurally from licensed antifungal agents such as amphotericin B, triazoles and echinocandins. To understand the relationship between chemical structure and biological function, we isolated certain ASP2397 derivatives from the culture broth, and we further chemically converted the metal-free form to other derivatives.


Subject(s)
Acremonium/metabolism , Antifungal Agents/isolation & purification , Antifungal Agents/pharmacology , Coordination Complexes/pharmacology , Peptides, Cyclic/pharmacology , Aluminum/chemistry , Antifungal Agents/chemistry , Coordination Complexes/chemistry , Coordination Complexes/isolation & purification , Ferrichrome/pharmacology , Malaysia , Peptides, Cyclic/chemistry , Peptides, Cyclic/isolation & purification , RNA, Ribosomal, 28S/genetics
2.
J Antibiot (Tokyo) ; 67(10): 707-11, 2014 Oct.
Article in English | MEDLINE | ID: mdl-24865863

ABSTRACT

A novel antifungal agent, AS2077715, was isolated from the fermentation broth of a fungal strain (339855) identified as a new Capnodium species based on morphological characteristics and large-subunit ribosomal DNA sequencing. AS2077715 was isolated as a white powder via solvent extraction, HP-20 and ODS-B column chromatography and crystallization, and was determined to have the molecular formula C25H41NO7. AS2077715 has a structure related to that of funiculosin, an inhibitor of mitochondrial cytochrome bc1 complex (complex III), and showed antifungal activity against Trichophyton species.


Subject(s)
Antifungal Agents/isolation & purification , Antifungal Agents/pharmacology , Ascomycota/metabolism , Biological Products/isolation & purification , Biological Products/pharmacology , Ascomycota/classification , Ascomycota/genetics , Ascomycota/growth & development , Cluster Analysis , DNA, Fungal/chemistry , DNA, Fungal/genetics , DNA, Ribosomal/chemistry , DNA, Ribosomal/genetics , Enzyme Inhibitors/isolation & purification , Enzyme Inhibitors/pharmacology , Fermentation , Genes, rRNA , Magnetic Resonance Spectroscopy , Molecular Sequence Data , Molecular Structure , Phylogeny , RNA, Fungal/genetics , RNA, Ribosomal/genetics , Sequence Analysis, DNA , Trichophyton/drug effects
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