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Med Hypotheses ; 146: 110395, 2021 Jan.
Article in English | MEDLINE | ID: mdl-33341328

ABSTRACT

We present the hypothesis to the scientific community actively designing clinical trials and recommending public health guidelines to control the pandemic that - "Tetanus vaccination may be contributing to reduced severity of the COVID-19 infection" - and urge further research to validate or invalidate the effectiveness of the tetanus toxoid vaccine against COVID-19. This hypothesis was revealed by an explainable artificial intelligence system unleashed on open public biomedical datasets. As a foundation for scientific rigor, we describe the data and the artificial intelligence system, document the provenance and methodology used to derive the hypothesis and also gather potentially relevant data/evidence from recent studies. We conclude that while correlations may not be reason for causation, correlations from multiple sources is more than a serendipitous coincidence that is worthy of further and deeper investigation.


Subject(s)
COVID-19/prevention & control , Models, Biological , Pandemics/prevention & control , SARS-CoV-2 , Tetanus Toxoid/pharmacology , Artificial Intelligence , COVID-19/immunology , COVID-19/virology , COVID-19 Vaccines/pharmacology , Clostridium tetani/genetics , Clostridium tetani/immunology , Databases, Pharmaceutical , Drug Repositioning/statistics & numerical data , Humans , SARS-CoV-2/genetics , SARS-CoV-2/immunology , Sequence Homology, Amino Acid , Severity of Illness Index , Spike Glycoprotein, Coronavirus/genetics , Spike Glycoprotein, Coronavirus/immunology , Tetanus Toxin/genetics , Vaccination
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